5 completed, 1 terminated, 1 withdrawn. 7 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 5, Terminated 1, Withdrawn 1 |
| Phase 1 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
Follow Scleroderma, Localized: new trials by email Literature Review of Scleroderma, Localized trials Research Report on Scleroderma, Localized
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial to Evaluate Efficacy and Safety of Dupilumab in Localized Scleroderma Dupilumab 300Mg Solution for Injection, Placebo - Localized Scleroderma | Phase 2 | Completed | University of Cologne | 45 | 2020-05-19 | 2024-10-26 |
| A Study of FCX-013 Plus Veledimex for the Treatment of Moderate to Severe Localized Scleroderma (Morphea) FCX-013, veledimex - Morphea, Scleroderma, Localized | Phase 1 / Phase 2 | Terminated | Castle Creek Biosciences, LLC. | 1 | 2019-12-18 | 2024-01-23 |
| Study to Assess Sarilumab in Halting Progression of Morphea Sarilumab - Morphea, Plaque Form | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-09-01 | 2021-09-08 | |
| Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea Crisaborole - Morphea | Phase 2 | Completed | Duke University | 8 | 2018-09-01 | 2021-04-01 |
| A Protocol Based Treatment for Debilitating Fibrosing Skin Disorders With (Anti-CD 20), Rituximab, Evaluating Safety and Efficacy Rituximab - Debilitating Fibrosing Skin Disorders (Localised Scleroderma, Eosinophilic Fasciitis) | Phase 2 | Completed | University Hospital, Ghent | 3 | 2009-06-01 | 2021-07-13 |
| Efficacy and Safety of Imatinib in Scleroderma imatinib mesylate - Scleroderma, Localized, Scleroderma, Systemic | Phase 2 | Completed | University Hospital, Bordeaux | 28 | 2007-12-01 | 2026-05-14 |
| Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix UVB Irradiation - Keloid, Scleroderma, Localized | Phase 1 / Phase 2 | Completed | University of Michigan | 33 | 2002-08-01 | 2015-05-01 |
Scleroderma, Diffuse (3) · Acne Keloid (1) · Cicatrix (1) · Eosinophilic Fasciitis (1) · Granuloma Annulare (1) · Keloid (1) · Scleroderma, Systemic (1)
Connective Tissue Diseases (7) · Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Scleroderma, Systemic (2) · Acneiform Eruptions (1) · Collagen Diseases (1) · Fibrosis (1) · Folliculitis (1) · Granuloma (1) · Hair Diseases (1) · Necrobiotic Disorders (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Drug Delivery Systems (1) · Imatinib Mesylate (1) · Injections (1) · Rituximab (1) · Solutions (1) · crisaborole (1) · dupilumab (1) · sarilumab (1) · veledimex (1)
Castle Creek Biosciences, LLC. (1) · Duke University (1) · Massachusetts General Hospital (1) · University Hospital, Bordeaux (1) · University Hospital, Ghent (1) · University of Cologne (1) · University of Michigan (1)
United States (4) · Belgium (1) · France (1) · Germany (1)
Adela Cardones, MD (1) · Filip De Keyser, MD, PhD (1) · John J Voorhees, MD (1) · Sabine Eming, Prof. Dr. (1)
2019 (1)