6 completed, 5 terminated, 3 unknown, 2 not yet recruiting. 20 Phase 1, 8 Phase 2.
Follow Rupture: new trials by email Literature Review of Rupture trials Research Report on Rupture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery BPC-157, Sham (No Treatment) - Rotator Cuff Tear | Phase 1 | Not yet recruiting | University of Arkansas | 30 | 2027-01-01 | 2026-09-03 |
| Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears Adipose derived stem cell injection, Placebo - Rotator Cuff Tears, Rotator Cuff Injuries | Phase 1 / Phase 2 | Not yet recruiting | University of Southern Denmark | 30 | 2026-10-01 | 2026-09-30 |
| Tuberoplasty Versus Balloon Spacer biologic tuberoplasty, subacromial balloon spacer - Rotator Cuff Tears | Phase 1 / Phase 2 | Recruiting | University of Minnesota | 40 | 2024-12-02 | 2026-01-07 |
| Stem Cell Treatment for Regeneration of the Rotator Cuff (Lipo-Cuff Study) Stem-cell treatment, Standard care - Rotator Cuff Tears, Rotator Cuff Injuries | Phase 1 | Enrolling by invitation | University of Southern Denmark | 30 | 2024-09-03 | 2026-10-08 |
| CBD for Pain Following Orthopedic Shoulder Surgery Epidiolex, Placebo oral solution - Shoulder Osteoarthritis, Rotator Cuff Injuries | Phase 1 / Phase 2 | Recruiting | The Methodist Hospital Research Institute | 80 | 2024-05-24 | 2026-04-16 |
| Breast Stimulation vs. Low Dose Oxytocin Augmentation for Labor Induction Breast stimulation, Oxytocin - Labor Onset and Length Abnormalities, Uterine Rupture | Phase 1 / Phase 2 | Unknown | Western Galilee Hospital-Nahariya | 200 | 2022-10-01 | 2022-08-22 |
| Ortho-R® for Rotator Cuff Repair Compared With Standard of Care Rotator Cuff Repair Without Ortho-R® Ortho-R/PRP - Rotator Cuff Tears | Phase 1 / Phase 2 | Unknown | ChitogenX Inc | 78 | 2022-07-26 | 2023-03-21 |
| Optimal Dosing of IC-Green for Visualization of Rotator Cuff Vascularity Using Advanced Imaging Modality Arthroscopy Indocyanine Green - Rotator Cuff Tears | Phase 1 | Completed | NYU Langone Health | 20 | 2021-01-27 | 2026-07-09 |
| Phase 1/2 Clinical Study of TPX-115 in Patients With Partial-Thickness Rotator Cuff Tear TPX-115, Placebo - Rotator Cuff Injuries | Phase 1 / Phase 2 | Completed | Tego Science, Inc. | 49 | 2020-10-26 | 2023-05-18 |
| The Effects of Platelet-Rich Plasma Versus Prolotherapy On Rotator Cuff Tendinopathy: A Randomized Controlled Trial. Platelet-Rich Plasma, Prolotherapy - Rotator Cuff Tendinosis, Supraspinatus Strain | Phase 1 | Completed | University of Malaya | 60 | 2020-02-17 | 2022-11-02 |
| E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults E-CEL UVEC - Rotator Cuff Tears, Muscle Atrophy or Weakness | Phase 1 | Active not recruiting | Hospital for Special Surgery, New York | 20 | 2019-11-20 | 2026-11-06 |
| Safety/Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults With aSAH EG-1962 (nimodipine microparticles), Enteral Nimodipine - Subarachnoid Hemorrhage, Aneurysmal | Phase 1 | Terminated | Edge Therapeutics Inc | 6 | 2016-09-01 | 2018-07-26 |
| The Effect of Platelet Rich Plasma Injection Combined With Exercise Rehabilitation in Patients With Rotator Cuff Tear Platelet-Rich Plasma, Hyaluronic Acid, Exercise - Rotator Cuff Tear | Phase 1 | Completed | Taipei Veterans General Hospital, Taiwan | 30 | 2014-03-04 | 2018-06-07 |
| Functional Outcome Comparison of Implant-Free Bone-Patellar Tendon Autograft in Arthroscopic ACL Reconstruction Patella tendon & bone block autograft + press-fit femoral technique, Arthroscopic ACL reconstruction, Hamstring tendon autograft + implant fixation - Anterior Cruciate Ligament Injuries, Ligament; Rupture, Knee, Spontaneous | Phase 1 / Phase 2 | Completed | Universitas Indonesia | 32 | 2013-03-01 | 2019-10-11 |
| Utilization of AMSC to Enhance Rotator Cuff Repair - Safety and Efficacy Suspension of human autologous MSC 3P - Rotator Cuff Tear | Phase 1 / Phase 2 | Terminated | Bioinova, s.r.o. | 9 | 2012-12-12 | 2019-02-15 |
| Platelet Rich Plasma vs. Corticosteroid Injection in the Treatment of Partial Rotator Cuff Tears Platelet Rich Plasma (PRP), Corticosteroid - Rotator Cuff Tear | Phase 1 | Terminated | University of North Carolina, Chapel Hill | 12 | 2012-11-01 | 2017-04-17 |
| Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus Muscle Lesions mesenchymal stem cells, without mesenchymal stem cells - Rotator Cuff Tear | Phase 1 | Unknown | Hospital Znojmo | 50 | 2012-01-01 | 2017-09-07 |
| Platelet-Rich Plasma Therapy for Shoulder Pain in Persons With Spinal Cord Injury Platelet-rich plasma (PRP) therapy - Shoulder Pain, Rotator Cuff Tendinitis | Phase 1 | Completed | Kessler Foundation | 6 | 2011-05-01 | 2013-01-15 |
| Study Evaluating Safety Of BMP-655/ACS As An Adjuvant Therapy For Rotator Cuff Repair BMP-655/ACS or Standard of Care - Rotator Cuff Tear | Phase 1 | Terminated | Pfizer | 13 | 2010-09-01 | 2012-04-13 |
| A Safety Study Of BMP-655/ACS As An Adjuvant Therapy For Treatment Of Rotator Cuff Tears BMP-655/ACS+Standard of care or Standard of care - Rotator Cuff Tear | Phase 1 | Terminated | Pfizer | 23 | 2010-06-01 | 2013-02-22 |
Rotator Cuff Injuries (17) · Aneurysm (1) · Anterior Cruciate Ligament Injuries (1) · Asthenia (1) · Motor Activity (1) · Muscular Atrophy (1) · Rotator Cuff Tear Arthropathy (1) · Shoulder Pain (1) · Spinal Cord Injuries (1) · Subarachnoid Hemorrhage (1) · Tendinopathy (1) · Uterine Rupture (1)
Wounds and Injuries (20) · Shoulder Injuries (17) · Tendon Injuries (17) · Musculoskeletal Diseases (3) · Nervous System Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Central Nervous System Diseases (2) · Joint Diseases (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Arthralgia (1) · Arthritis (1) · Atrophy (1) · Behavior (1)
Standard of Care (3) · Adrenal Cortex Hormones (1) · BPC 157 (1) · Bupivacaine (1) · Cannabidiol (1) · Dexamethasone (1) · EG-1962 (1) · Exercise (1) · Hyaluronic Acid (1) · Indocyanine Green (1) · Oxytocin (1) · Prolotherapy (1) · Therapeutics (1) · Triamcinolone Acetonide (1) · salicylhydroxamic acid (1)
Pfizer (2) · University of Southern Denmark (2) · Bioinova, s.r.o. (1) · ChitogenX Inc (1) · Edge Therapeutics Inc (1) · Hospital Znojmo (1) · Hospital for Special Surgery, New York (1) · Kessler Foundation (1) · NYU Langone Health (1) · Taipei Veterans General Hospital, Taiwan (1) · Tego Science, Inc. (1) · The Methodist Hospital Research Institute (1) · Universitas Indonesia (1) · University of Arkansas (1) · University of Malaya (1)
United States (9) · Canada (1) · Czechia (1) · Denmark (1) · Germany (1) · Israel (1) · Japan (1) · Malaysia (1) · Netherlands (1) · South Korea (1) · Taiwan (1)
Allison Rao (1) · Andri MT Lubis, MD, PhD (1) · Berkoff David, MD (1) · Brendan C Mackinnon-Patterson, BS, MPH, MD (1) · Joo Han Oh, Ph.D (1) · Kirk Campbell (1) · Lars Frich (1) · Lars H. Frick, Prof. (1) · Maya Wolf, MD (1) · Patrick McCulloch, MD (1) · Petr Lesny, MD (1) · R. Loch Macdonald, MD, PhD (1)
PMID 28932752, PMID 22958838, PMID 2323151, PMID 25446135, PMID 26390274, PMID 31000394, PMID 32379581, PMID 32985652, PMID 37624739, PMID 3791738, PMID 39427182, PMID 8020238, PMID 9372778