25 completed, 4 unknown, 3 active not recruiting, 2 not yet recruiting. 21 Not applicable, 5 Phase 2, 4 Phase 4, 3 Phase 3, 2 Phase 1.
Follow Prolotherapy: new trials by email Literature Review of Prolotherapy trials Research Report on Prolotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| Comparison of Platelet-Rich Plasma and Prolotherapy for Plantar Fasciitis platelet-rich plasma injection, Prolotherapy with 25% Dextrose - Planter Fasciitis | Not applicable | Active not recruiting | Bangladesh Medical University | 68 | 2026-04-01 | 2026-09-30 |
| Comparison of the Effectiveness of Dextrose Prolotherapy and Extracorporeal Shock Wave Therapy (ESWT) in Plantar Fasciitis Dextrose Prolotherapy, Extracorporeal Shock Wave Therapy (ESWT) - Plantar Fasciitis | Not applicable | Not yet recruiting | Kanuni Sultan Suleyman Training and Research Hospital | 60 | 2025-11-15 | 2025-11-18 |
| Assessment of Injectable PRF Versus Dextrose Injection in Temporomandibular Joint in Anterior Disc Displacement With Reduction PRF treatment group, Dextrose 20% Prolotherapy - TMD | Phase 2 | Active not recruiting | Cairo University | 24 | 2025-10-10 | 2026-09-01 |
| Comparison of Prolotherapy and Rehabilitation Treatments in Low Back Pain (CPRTLBP) Prolotherapy, Balneotherapy plus Physiotherapy, Physiotherapy - Low Back Pain | Not applicable | Completed | Balnear and Rehabilitation Sanatorium Techirghiol | 84 | 2025-04-01 | 2026-02-10 |
| Combined Effect of Prolotherapy and Personalized Physical Activity on Knee Osteoarthritis Progression Prolotherapy Only, Prolotherapy, Personalized Physical Activity Program - Prolotherapy | Not applicable | Completed | Gadjah Mada University | 74 | 2024-07-10 | 2026-01-21 |
| Comparison of the Efficacy of Dextrose Prolotherapy and Mesotherapy in Lateral Epicondylitis Mesotherapy - Lateral Epicondylitis | Not applicable | Completed | Haydarpasa Numune Training and Research Hospital | 84 | 2024-04-01 | 2025-04-02 |
| Efficacy of Dextrose Prolotherapy Compare With ESWT in the Treatment of Chronic Rotator Cuff Tendinopathy Prolotherapy, Extracorporeal shock wave therapy (ESWT) - Chronic Rotator Cuff Tendinopathy | Not applicable | Completed | Mahidol University | 24 | 2023-11-10 | 2024-11-22 |
| Precision Medicine for Nociception, Sngception and Proprioception. LASER, Ultrasound, Prolotherapy - Rehabilitation, Pain, Shoulder | Not applicable | Active not recruiting | National Taiwan University Hospital | 160 | 2023-10-01 | 2026-08-20 |
| Chronic Plantar Fasciitis: Which is More Effective? Prolotherapy/Extracorporeal Shock Wave Therapy? extracorporeal shock wave therapy, Prolotherapy - Chronic Plantar Fasciitis | Not applicable | Completed | Ankara City Hospital Bilkent | 70 | 2023-10-01 | 2024-12-27 |
| Examining the Effect of Prolotherapy on Quality of Life and Painkiller Use in Patients With Knee Pain Prolotherapy - The Aim of This Research is to Investigate the Effect of Prolotherapy on Quality of Life and Painkiller Use in Patients With Chronic Knee Pain | Not applicable | Completed | Bursa Yuksek Ihtisas Training and Research Hospital | 65 | 2023-05-01 | 2024-04-04 |
| Ultrasound-Guided Vs Non-Guided Prolotherapy for Internal Derangement of Temporomandibular Joint. a Randomized Clinical Trial Prolotherapy - TMJ Disc Disorder, Ultrasound Therapy; Complications | Not applicable | Completed | Cairo University | 22 | 2022-11-10 | 2024-09-19 |
| Caudal Epidural Prolotherapy Versus Steroids in Failed Back Surgery Syndrome medthylprednisolone, prolotherapy - Chronic Pain Syndrome | Phase 2 / Phase 3 | Completed | Alexandria University | 90 | 2022-04-20 | 2024-11-29 |
| Prolotherapy Intervention in Patient With Frozen Shoulder Dextrose 15 % in Water, Normal Saline 20 mL Injection - Frozen Shoulder | Phase 4 | Completed | Bumi Herman | 32 | 2021-12-01 | 2022-12-22 |
| Different Concentrations of Dextrose Prolotherapy Treatment in Knee Osteoartritis Prolotherapy, Home based exercise program, Hotpack therapy - Knee Osteoarthritis | Not applicable | Completed | Turkish League Against Rheumatism | 128 | 2020-03-01 | 2022-09-13 |
| The Effects of Platelet-Rich Plasma Versus Prolotherapy On Rotator Cuff Tendinopathy: A Randomized Controlled Trial. Platelet-Rich Plasma, Prolotherapy - Rotator Cuff Tendinosis, Supraspinatus Strain | Phase 1 | Completed | University of Malaya | 60 | 2020-02-17 | 2022-11-02 |
| Comparative Efficacy of Prolotherapy and Dry Needling in Management of ADD Prolotherapy, Dry needling - Anterior Disk Displacement TMJ | Phase 4 | Unknown | Postgraduate Institute of Dental Sciences Rohtak | 50 | 2020-01-05 | 2020-03-24 |
| Effect of Prolotherapy in Knee Osteoarthritis. Prolotherapy with 25% Dextrose - Knee Osteoarthritis | Not applicable | Completed | University of Alexandria | 63 | 2019-12-15 | 2023-04-05 |
| Prolotherapy Intervention Effect in Patient With Knee Osteoarthritis Prolotherapy, Sodium Hyaluronate - Knee Osteoarthritis | Phase 4 | Completed | Hasanuddin University | 36 | 2019-09-01 | 2020-11-19 |
| Biotensegrity: Thoracolumbar Fascial Integrity in Chronic Low Back Pain Prolotherapy - Musculoskeletal Pain, Low Back Pain | Completed | ProloAustin | 100 | 2019-06-06 | 2023-11-18 |
Showing 20 of 35. Sign in to see all of them.
Tennis Elbow (7) · Osteoarthritis, Knee (6) · Chronic Pain (2) · Fasciitis, Plantar (2) · Low Back Pain (2) · Musculoskeletal Pain (2) · Rotator Cuff Injuries (2) · Bursitis (1) · Chondromalacia Patellae (1) · Ehlers-Danlos Syndrome (1) · Ehlers-Danlos syndrome type 3 (1) · Joint Dislocations (1) · Joint Instability (1) · Motor Activity (1) · Myofascial Pain Syndromes (1)
Cairo University (3) · Alexandria University (1) · Ankara City Hospital Bilkent (1) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (1) · Balnear and Rehabilitation Sanatorium Techirghiol (1) · Bangladesh Medical University (1) · Bumi Herman (1) · Bursa Yuksek Ihtisas Training and Research Hospital (1) · CM Chungmu Hospital (1) · Chang Gung Memorial Hospital (1) · Christine M. Kleinert Institute for Hand and Microsurgery (1) · Ege University (1) · Gadjah Mada University (1) · Hacettepe University (1) · Hasanuddin University (1)
Turkey (Türkiye) (8) · Egypt (5) · United States (5) · Indonesia (3) · Taiwan (3) · South Korea (2) · Bangladesh (1) · Canada (1) · India (1) · Malaysia (1) · Mexico (1) · Romania (1) · Thailand (1)
Alexios G Carayannopoulos, DO, MPH (1) · Bradley Fullerton, MD (1) · Cleotilde Fuentes Orozco, PhD, MD (1) · Endy Adnan, PhD (1) · Hakan Demirci, Professor (1) · Helene Bertrand, MD, CCFP (1) · Hyun-Kyung Do (1) · Irawan Yusuf, PhD (1) · Irfan Idris, PhD (1) · Jae-Young Lim (1)
PMID 10738416, PMID 11874310, PMID 15920223, PMID 16223407, PMID 18490916, PMID 19549615, PMID 19913821, PMID 19927076, PMID 20021438, PMID 20171677, PMID 21256210, PMID 22515800, PMID 25446135, PMID 25623739, PMID 26301385, PMID 26390274, PMID 28778254, PMID 28920043, PMID 29465566, PMID 29793480, PMID 29883193, PMID 30231245, PMID 30592331, PMID 30908578, PMID 31000394, PMID 31431652, PMID 32931308, PMID 33217236, PMID 34590307, PMID 34608709, PMID 37540383, PMID 42075495, PMID 7832306
R21AT003969 (1)