Shoulder Injuries: Clinical Trials

588 completed, 209 unknown, 111 recruiting, 71 not yet recruiting. 720 Not applicable, 56 Phase 4, 41 Phase 2, 28 Phase 3, 22 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	720	Completed 394, Unknown 118, Recruiting 76, Not yet recruiting 42, Withdrawn 29, Active not recruiting 27, Terminated 22, Suspended 7, Enrolling by invitation 5
Phase 4	56	Completed 25, Unknown 15, Recruiting 4, Terminated 4, Withdrawn 4, Active not recruiting 3, Not yet recruiting 1
Phase 2	41	Completed 16, Unknown 11, Recruiting 4, Terminated 3, Withdrawn 3, Not yet recruiting 2, Active not recruiting 1, Suspended 1
Phase 3	28	Completed 12, Unknown 8, Withdrawn 3, Active not recruiting 2, Terminated 2, Recruiting 1
Phase 1	22	Completed 9, Terminated 4, Unknown 3, Not yet recruiting 2, Recruiting 2, Active not recruiting 1, Enrolling by invitation 1
Early Phase 1	4	Completed 2, Not yet recruiting 1, Unknown 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Estradiol Supplementation and Rotator Cuff Repair Transdermal estrogen, Rotator Cuff Repair Surgery - Rotator Cuff Tears, Rotator Cuff Injuries	Phase 2	Not yet recruiting	University of Utah	58	2028-03-01	2026-03-19
Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL) Exercise Therapy, Extracorporeal Shockwave Therapy, Ultrasound-Guided Percutaneous Irrigation - Rotator Cuff Tendinosis, Rotator Cuff Injuries	Not applicable	Suspended	University of Valencia	116	2028-01-01	2026-06-26
Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery BPC-157, Sham (No Treatment) - Rotator Cuff Tear	Phase 1	Not yet recruiting	University of Arkansas	30	2027-01-01	2026-09-03
Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode. Arthroscopic stabilization, Rehabilitation including a period of immobilization followed by physical therapy - Shoulder Dislocation	Not applicable	Not yet recruiting	McMaster University	30	2027-01-01	2026-10-07
Decellularized Human Placental Extracellular Matrix Tissue for Rotator Cuff Repair Augmentation Rotator Cuff Repair with Allograft Patch, Rotator Cuff Repair with No Augmentation - Rotator Cuff Tear	Not applicable	Not yet recruiting	Columbia University	120	2027-01-01	2026-09-10
Tapestry Rotator Cuff Repair PMCF Tapestry Biointegrative Implant - Rotator Cuff Tears, Rotator Cuff Injuries		Suspended	Zimmer Biomet	170	2026-12-28	2025-11-21
Nociplastic Pain in Patients Diagnosed With Subacromial Pain Syndrome (SAPS) Clinical evaluation - Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain		Not yet recruiting	Vejle Hospital	400	2026-10-19	2026-10-06
Pain Phenotype and Response to Corticosteroid Injection in Patients With Subacromial Pain Syndrome (SAPS) Clinical evaluation - Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain		Not yet recruiting	Vejle Hospital	134	2026-10-19	2026-10-07
Efficacy Evaluation of Intelligent Rehabilitation Programs Based on AI-Powered Digital Rehabilitation System for Subacromial Impingement Syndrome Home-based Rehabilitation Training Combined with Intelligent Rehabilitation Training, Traditional Rehabilitation Training, Prescribe home-based rehabilitation prescriptions for home rehabilitation training - Articular, Range of Motion	Not applicable	Not yet recruiting	Peking University Third Hospital	93	2026-10-14	2026-06-10
OMT for Overhead Throwing Performance: A Study on Shoulder and Hip Interventions Osteopathic Manipulative Treatment - Pitch, Baseball Pitcher	Not applicable	Not yet recruiting	William Carey University	15	2026-10-14	2026-10-16
Ultrasound and Shear Wave Elastography for Assessment of the Quality of Rotator Cuff Muscles Rotator Cuff Injuries, Rotator Cuff Tear		Not yet recruiting	Assiut University	70	2026-10-01	2026-09-23
Remote App-based Rehabilitation After Rotator Cuff Repair Telerehabilitation, Conventional home exercise program - Rotator Cuff Tear, Telemedecine	Not applicable	Not yet recruiting	Hanoi Medical University	102	2026-10-01	2026-09-22
Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears Adipose derived stem cell injection, Placebo - Rotator Cuff Tears, Rotator Cuff Injuries	Phase 1 / Phase 2	Not yet recruiting	University of Southern Denmark	30	2026-10-01	2026-09-30
Smallest Worthwhile Effect of Rotator Cuff Repair and Supervised Exercise Rotator Cuff Tears (RCTs)		Not yet recruiting	Kırklareli University	104	2026-10-01	2026-08-21
Optimized Costoclavicular Block for Elderly Proximal Humeral Fracture Surgery Costoclavicular Brachial Plexus Block, Interscalene Brachial Plexus Block, Superficial Cervical Plexus Block - Proximal Humeral Fracture, Anesthesia, Regional	Not applicable	Withdrawn	Shanghai Tong Ren Hospital		2026-10-01	2026-07-09
Percutaneous Tenotomy Versus Radiofrequency Ablation for Rotator Cuff Tear - Related Pain. Percutaneous tenotomy of the long head of the biceps tendon (LHBT), Ultrasound guided radiofrequency ablation of the suprascapular nerve - Rotator Cuff Tear, Pain Management	Not applicable	Not yet recruiting	Centre of Postgraduate Medical Education	60	2026-10-01	2026-10-16
Arthroscopic Rotator Cuff Repair With Long Head of Biceps Transposition and Acellular Dermal Matrix Augmentation for Large to Massive Incompletely Repairable Rotator Cuff Tears Rotator Cuff Repair, Long Head of the Biceps Tendon Transposition, Acellular Dermal Matrix (Allograft) Augmentation - Rotator Cuff Tears, Rotator Cuff Injuries	Not applicable	Recruiting	Tam Anh Research Institute	40	2026-09-16	2026-10-19
Does MI Have a Therapeutic Role in Arthroscopic Rotator Cuff Repair? Motor Imagery, Physical Therapy - Rotator Cuff Tears, Motor Imagery	Not applicable	Suspended	Alanya Alaaddin Keykubat University	36	2026-09-15	2025-10-03
The Combined Effect of Thoracic Manipulation and Instrument-assisted Soft Tissue Mobilization in Patients With Shoulder Impingement Syndrome conventional physical therapy, thoracic manibulation, instrument assisted soft tissue mobilization - Shoulder Impingement Syndrome	Not applicable	Not yet recruiting	Cairo University	80	2026-09-10	2026-09-02
An Innovative Proprioceptive Instrument for Upper Extremities Stroke, Shoulder Impingement Syndrome		Not yet recruiting	National Cheng-Kung University Hospital	280	2026-09-01	2026-08-21

Showing 20 of 1134. Sign in to see all of them.

Narrower conditions

Rotator Cuff Injuries (579)  ·  Shoulder Impingement Syndrome (315)  ·  Shoulder Pain (175)  ·  Shoulder Fractures (110)  ·  Shoulder Dislocation (94)  ·  Pain (51)  ·  Motor Activity (32)  ·  Pain, Postoperative (27)  ·  Tendinopathy (25)  ·  Bursitis (19)  ·  Bankart Lesions (14)  ·  Humeral Fractures (14)  ·  Joint Dislocations (13)  ·  Musculoskeletal Diseases (13)

Broader conditions

Wounds and Injuries (1127)  ·  Tendon Injuries (584)  ·  Rupture (567)  ·  Musculoskeletal Diseases (528)  ·  Joint Diseases (508)  ·  Pathological Conditions, Signs and Symptoms (292)  ·  Signs and Symptoms (262)  ·  Neurologic Manifestations (259)  ·  Pain (197)  ·  Arthralgia (174)  ·  Fractures, Bone (124)  ·  Joint Dislocations (83)  ·  Pathologic Processes (69)  ·  Nervous System Diseases (49)

Interventions

Exercise (36)  ·  Physical Therapy Modalities (32)  ·  Bupivacaine (16)  ·  Exercise Therapy (15)  ·  Rehabilitation (14)  ·  Control Groups (12)  ·  Saline Solution (12)  ·  Adrenal Cortex Hormones (11)  ·  Dexamethasone (11)  ·  Ropivacaine (11)  ·  Lidocaine (10)  ·  Musculoskeletal Manipulations (9)  ·  Standard of Care (9)  ·  Ultrasonography (9)  ·  Blood Flow Restriction Therapy (8)

Sponsors

Cairo University (37)  ·  Peking University Third Hospital (21)  ·  Zimmer Biomet (21)  ·  Hacettepe University (15)  ·  National Taiwan University Hospital (14)  ·  Istanbul University - Cerrahpasa (13)  ·  National Yang Ming Chiao Tung University (11)  ·  Riphah International University (11)  ·  Rothman Institute Orthopaedics (10)  ·  Chuncheon Sacred Heart Hospital (9)  ·  Smith & Nephew, Inc. (9)  ·  Dokuz Eylul University (8)  ·  Schulthess Klinik (8)  ·  University of Calgary (8)  ·  University of Sao Paulo (8)

Countries

United States (239)  ·  Turkey (Türkiye) (163)  ·  Canada (67)  ·  Egypt (52)  ·  Spain (49)  ·  France (44)  ·  Taiwan (44)  ·  China (38)  ·  South Korea (34)  ·  Switzerland (33)  ·  Denmark (32)  ·  Brazil (29)  ·  Italy (28)  ·  United Kingdom (28)  ·  Pakistan (25)

Top investigators

Guoqing Cui (7)  ·  Jung-Taek Hwang, MD, PhD (6)  ·  Peter Lapner, MD (5)  ·  Yin-Liang Lin, PhD (5)  ·  Burak Menek, PhD (3)  ·  Catherine J Fedorka, MD (3)  ·  Erin Osborn (3)  ·  Hassan Achakri (3)  ·  Ivan Wong, MD (3)  ·  Kathleen Derwin, PhD (3)  ·  Matthias Flury, Dr (3)

Results publications

PMID 35727196, PMID 22349588, PMID 24880194, PMID 33935152, PMID 10696154, PMID 12449254, PMID 16331304, PMID 19771196, PMID 20108851, PMID 20710088, PMID 23619203, PMID 25213604, PMID 25523242, PMID 25664288, PMID 25907145, PMID 25936465, PMID 26471852, PMID 28416022, PMID 28446376, PMID 28652066, PMID 28932752, PMID 29423865, PMID 30134883, PMID 30248039, PMID 31141546, PMID 31378683, PMID 31726927, PMID 32975624, PMID 33123644, PMID 33272959, PMID 33399396, PMID 35033043, PMID 35109905, PMID 40165544, PMID 8020238, PMID 9850776, PMID 10037543, PMID 10633896, PMID 10797220, PMID 10976589, PMID 11304107, PMID 11347400, PMID 1159142, PMID 11679610, PMID 11688948, PMID 11912097, PMID 12368787, PMID 12535501, PMID 12606927, PMID 12629425

NIH funding

2019 (4), 2017 (2), 2009 (1), 2015 (1), 2018 (1), 2023 (1), K23AR059199 (1), R01AR051026 (1), R01AR074989 (1), R01HD084423 (1), R21AR082588 (1), U34AR069201 (1)