47 completed, 22 recruiting, 11 active not recruiting, 10 terminated. 101 Phase 1, 36 Phase 2.
Follow Rhabdomyosarcoma: new trials by email Literature Review of Rhabdomyosarcoma trials Research Report on Rhabdomyosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors Becotatug Vedotin - Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Nasopharyngeal Carcinoma | Phase 1 | Recruiting | Sun Yat-sen University | 51 | 2026-05-30 | 2026-05-13 |
| Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Hepatocellular Carcinoma | Phase 1 | Not yet recruiting | Seattle Children's Hospital | 21 | 2026-04-01 | 2025-11-04 |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE) Selective Antigen Specific dTβRII-expressing T cells combined with B7-H3 CAR T cells - Rhabdomyosarcoma, Ewing Sarcoma | Phase 1 | Recruiting | Children's National Research Institute | 18 | 2026-01-27 | 2026-08-13 |
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors Lutetium Lu 177-Edotreotide, Amino Acid Solution - Somatostatin Receptor Positive, NETs | Phase 1 | Recruiting | ITM Solucin GmbH | 20 | 2025-09-26 | 2026-10-27 |
| FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma fludarabine, cyclophosphamide, cetuximab - Rhabdomyosarcoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 50 | 2025-09-22 | 2026-10-16 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors PEEL-224, Vincristine, Temozolomide (TMZ) - Refractory Solid Tumors, Relapsed Solid Tumors | Phase 1 / Phase 2 | Recruiting | Theodore Laetsch | 59 | 2025-03-23 | 2026-10-06 |
| Preliminary Clinical Study of Entinostat in Children With Malignant Soft Tissue Sarcoma Harboring PAX-family Gene Abnormalities Entinostat, VAC/VTC chemotherapy - Soft Tissue Sarcoma | Phase 1 | Recruiting | Beijing Tongren Hospital | 16 | 2025-03-15 | 2026-10-22 |
| A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer Cobolimab, Dostarlimab - Melanoma, Hodgkin Lymphoma | Phase 1 / Phase 2 | Active not recruiting | GlaxoSmithKline | 83 | 2025-03-06 | 2025-11-12 |
| Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas PEEL-224, Temozolomide, Vincristine - Sarcoma, Sarcoma, Ewing | Phase 1 / Phase 2 | Recruiting | David S Shulman, MD | 63 | 2025-01-27 | 2026-02-19 |
| Vincristine and Temozolomide in Combination With PEN-866 for Adolescents and Young Adults With Relapsed or Refractory Solid Tumors PEN-866, Vincristine, Temozolomide - Sarcoma, Ewing, Rhabdomyosarcoma | Phase 1 / Phase 2 | Suspended | National Cancer Institute (NCI) | 64 | 2024-10-31 | 2026-03-16 |
| Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors Silmitasertib, Irinotecan, Temozolomide - Neuroblastoma, Ewing Sarcoma | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 104 | 2024-10-30 | 2026-10-06 |
| Effectiveness of Pucotenlimab Combined With Standard Chemotherapy Regimen Pucotenlimab - Rhabdomyosarcoma, Pediatric Cancer | Phase 1 / Phase 2 | Recruiting | Sun Yat-sen University | 82 | 2024-06-06 | 2024-06-13 |
| Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors CARE T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Recruiting | Baylor College of Medicine | 24 | 2024-05-24 | 2026-08-06 |
| Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants LN-145/LN-144 - Soft Tissue Sarcoma, Primary Central Nervous System Carcinoma | Phase 1 | Terminated | Iovance Biotherapeutics, Inc. | 5 | 2024-03-28 | 2026-10-16 |
| Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision) Peptide vaccine IPX - Ewing Sarcoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University Hospital Tuebingen | 30 | 2023-09-19 | 2026-05-04 |
| VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors Atezolizumab, Vincristine, Irinotecan - Solid Tumor, Rhabdomyosarcoma | Phase 1 / Phase 2 | Active not recruiting | University of Texas Southwestern Medical Center | 23 | 2023-04-18 | 2026-11-04 |
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Sarcoma, Ewing (56) · Neuroblastoma (53) · Sarcoma (42) · Osteosarcoma (41) · Wilms Tumor (31) · Rhabdoid Tumor (19) · Medulloblastoma (16) · Hepatoblastoma (15) · Neoplasms (15) · Recurrence (14) · Sarcoma, Synovial (14) · Desmoplastic Small Round Cell Tumor (13) · Liposarcoma (13) · Neuroectodermal Tumors, Primitive, Peripheral (13)
Neoplasms by Histologic Type (101) · Neoplasms, Muscle Tissue (101) · Myosarcoma (100) · Neoplasms, Connective and Soft Tissue (100) · Neoplasms (86) · Neoplasms, Nerve Tissue (71) · Neoplasms, Connective Tissue (68) · Neoplasms, Glandular and Epithelial (67) · Neoplasms, Bone Tissue (64) · Neuroectodermal Tumors (63) · Neoplasms, Neuroepithelial (62) · Neoplasms, Germ Cell and Embryonal (60) · Sarcoma (59) · Neuroectodermal Tumors, Primitive (58) · Neoplasms by Site (52)
Irinotecan (11) · Temozolomide (11) · Vincristine (7) · Cyclophosphamide (5) · Filgrastim (5) · Busulfan (4) · Granulocyte Colony-Stimulating Factor (4) · Melphalan (4) · Doxorubicin (3) · Peripheral Blood Stem Cell Transplantation (3) · Topotecan (3) · fludarabine (3) · liposomal doxorubicin (3) · pegfilgrastim (3) · 130-nm albumin-bound paclitaxel (2)
National Cancer Institute (NCI) (13) · Baylor College of Medicine (7) · St. Jude Children's Research Hospital (7) · Emory University (4) · Seattle Children's Hospital (4) · Novartis Pharmaceuticals (3) · AeRang Kim (2) · Bayer (2) · Eisai Inc. (2) · Eli Lilly and Company (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Fred Hutchinson Cancer Center (2) · M.D. Anderson Cancer Center (2) · Sun Yat-sen University (2) · Theodore Laetsch (2)
United States (84) · Canada (12) · France (12) · Italy (11) · Spain (10) · Germany (9) · United Kingdom (9) · Australia (7) · Denmark (5) · Netherlands (4) · Switzerland (4) · Belgium (3) · China (3) · Czechia (3) · Austria (2)
David Steffin, MD (3) · AeRang Kim, MD, PhD (2) · Andrea Hayes-Jordan, MD (2) · Christine M Heske, M.D. (2) · Crystal L Mackall, M.D. (2) · Holly Meany, MD (2) · Aerang Kim, M.D. (1) · Alok Kothari, M.D. (1) · Amy Hont, MD (1) · Andreas Lammerich, MD (1) · Andrew Cluster, M.D. (1) · Ann Leen, PhD (1) · Anna Pawlowska, MD (1)
PMID 31401903, PMID 10797354, PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15592836, PMID 18391430, PMID 19088049, PMID 23071222, PMID 23382028, PMID 25452614, PMID 25858498, PMID 30410720, PMID 30697903, PMID 31876107, PMID 32192573, PMID 32554315, PMID 33047248, PMID 33305087, PMID 34004576, PMID 34157616, PMID 34383370, PMID 34780709, PMID 36371226, PMID 37178647, PMID 37194488, PMID 37398992, PMID 37606641, PMID 39255444, PMID 40313040, PMID 40937822
UM1CA097452 (2), UM1CA228823 (2), 2014 (1), 2016 (1), 2017 (1), 2018 (1), 2019 (1), 2023 (1), N01CM00071 (1), N01CM62206 (1), P30CA008748 (1), P30CA014599 (1), R01CA276684 (1), U01CA069856 (1)