125 completed, 53 recruiting, 37 unknown, 31 active not recruiting. 75 Phase 2, 69 Phase 1, 67 Not applicable, 23 Phase 3, 6 Early Phase 1.
Follow Retinitis Pigmentosa: new trials by email Literature Review of Retinitis Pigmentosa trials Research Report on Retinitis Pigmentosa
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Non-invasive Ultrasound Retinal Stimulation for Vision Restoration Non-invasive ultrasound retinal stimulation Device - Age-Related Macular Degeneration, Retinitis Pigmentosa | Not applicable | Not yet recruiting | University of Southern California | 5 | 2027-01-10 | 2026-01-08 |
| 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome N-acetylcysteine amide, Placebo - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Not yet recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-12-01 | 2026-07-01 |
| Study to Evaluate the Long-Term Safety of Ultevursen in Participants With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene No intervention, will not receive any active study intervention, Intravitreal Injection of Ultevursen - Retinitis Pigmentosa (RP), Usher Syndrome Type 2 | Phase 2 | Not yet recruiting | Laboratoires Thea | 81 | 2026-10-05 | 2026-09-01 |
| A 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome Placebo, NPI-001 - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-10-01 | 2026-10-13 |
| Safety Evaluation Study of Pitavastatin PLGA Nano-particle for Retinitis Pigmentosa ULREA-PVS-NP - Retinitis Pigmentosa (RP) | Phase 1 | Recruiting | Kyushu University | 21 | 2026-10-01 | 2026-10-07 |
| Study to Evaluate the Efficacy of a Single Intravitreal Injection of RTx-015 in Participants With Retinitis Pigmentosa (PERCEPT) RTx-015, Sham Control - Retinitis Pigmentosa (RP), Inherited Retinal Diseases | Phase 2 / Phase 3 | Recruiting | Ray Therapeutics, Inc. | 60 | 2026-10-01 | 2026-10-28 |
| Phase I/II Open-Label Trial of UGX202 for Advanced Retinitis Pigmentosa UGX202 Injection - Retinitis Pigmentosa (RP) | Phase 1 | Not yet recruiting | Suzhou UgeneX Therapeutics Co., Ltd. | 12 | 2026-09-28 | 2026-10-02 |
| Natural History Study of Advanced RCD Eye examinations, Questionnaire - Rod Cone Dystrophy | Not applicable | Recruiting | SparingVision | 100 | 2026-09-11 | 2026-10-08 |
| 9-cis Beta-Carotene-Rich Extract of Dunaliella Alga in Retinitis Pigmentosa Patients 9-cis beta-Carotene-rich extract of Dunaliella alga, Placebo Corn Oil - Retinitis Pigmentosa | Phase 1 / Phase 2 | Enrolling by invitation | Sheba Medical Center | 41 | 2026-07-26 | 2026-07-27 |
| Brain Stimulation Effects on Orientation and Mobility Skills in Adults With Vision Impairment Active hf-tRNS., Placebo/sham hf-tRNS - Retinitis Pigmentosa (RP), Rod Cone Dystrophy | Not applicable | Recruiting | University of Waterloo | 20 | 2026-07-01 | 2026-07-07 |
| Prospective, Randomized, Sham-controlled, Dose-finding I/II Trial of Safety and Efficacy of Modified Optogenetic Gene Therapy (ZM-02 Injection) ZM-02 (low dose), ZM-02 (high dose), ZM-02 (selected dose) - Retinitis Pigmentosa (RP) | Phase 1 / Phase 2 | Not yet recruiting | Zhongmou Therapeutics | 21 | 2026-06-25 | 2026-04-13 |
| Role of UC-MSC and CM to Inhibit Vision Loss in Retinitis Pigmentosa Phase I/II 1.5 x 10^6 UC-MSC + CM, 5 x 10^6 UC-MSC + CM - Retinitis Pigmentosa | Phase 2 / Phase 3 | Not yet recruiting | PT. Prodia Stem Cell Indonesia | 30 | 2026-05-01 | 2026-02-25 |
| Long-term Safety of UC-MSC Transplantation in Patients With Retinitis Pigmentosa Conditioned Medium (CM), Umbilical Cord Mesenchymal Stem Cell (UC-MSC) - Retinitis Pigmentosa | Not yet recruiting | PT. Prodia Stem Cell Indonesia | 18 | 2026-05-01 | 2026-02-25 | |
| Restoration of Central Vision With PRIMA in Patients With Photoreceptor Degeneration PRIMA Products - Stargardt Disease, Retinitis Pigmentosa (RP) | Not applicable | Recruiting | Science Corporation | 5 | 2026-04-22 | 2026-08-17 |
| Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance Transcorneal Electrical Stimulation using the OkuStim System - Retinitis Pigmentosa (RP), Usher Syndrome | Recruiting | Okuvision GmbH | 30 | 2026-04-20 | 2026-05-01 | |
| A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa DSP-3077 Retinal Sheet Cohort 1, DSP-3077 Retinal Sheet Cohort 2, DSP-3077 Retinal Sheet Cohort 3 - Retinitis Pigmentosa | Phase 1 / Phase 2 | Recruiting | Sumitomo Pharma America, Inc. | 12 | 2026-04-16 | 2026-04-17 |
| A Phase 1/2 Study in Healthy Volunteers and Participants With Autosomal Dominant Retinitis Pigmentosa (RHO-adRP) Phase 1b/2: Cohort 1 - OCT-980 Tablet, Phase 1b/2: Cohort 2 - OCT-980 Tablet, Phase 1b/2: Cohort 3 - OCT-980 Tablet - Retinitis Pigmentosa | Phase 1 / Phase 2 | Recruiting | Octant, Inc. | 18 | 2026-03-10 | 2026-09-24 |
| The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella Bardawil on Visual Functions in Adolescent Patients With Retinitis Pigmentosa Alga Dunaliella Bardawil powder, Placebo:Starch - Retinitis Pigmentosa | Phase 1 / Phase 2 | Not yet recruiting | Sheba Medical Center | 30 | 2026-03-01 | 2025-10-06 |
| Development and Evaluation of Functional Visual Field and Navigation Endpoints in Moderate to Profound Inherited Retinal Disease (DEFINE-IRD) Retinitis Pigmentosa, Stargardt Macular Dystrophy | Recruiting | Ray Therapeutics, Inc. | 25 | 2026-02-19 | 2026-03-31 | |
| Inherited Retinal Diseases: Natural History and Genotype-Phenotype Correlations No Intervention: Observational Cohort - Retinal Degenerations, Retinitis Pigmentosa (RP) | Not yet recruiting | IRCCS San Raffaele | 200 | 2026-01-01 | 2025-12-05 |
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Retinal Diseases (35) · Retinal Degeneration (33) · Usher Syndromes (33) · Eye Diseases (28) · Macular Degeneration (25) · Cone-Rod Dystrophies (19) · Retinal Dystrophies (19) · Bardet-Biedl Syndrome (18) · Vision Disorders (17) · Eye Diseases, Hereditary (16) · Stargardt Disease (15) · Choroideremia (14) · Glaucoma (13) · Diabetic Retinopathy (10)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (294) · Genetic Diseases, Inborn (288) · Eye Diseases, Hereditary (276) · Eye Diseases (267) · Retinal Dystrophies (260) · Retinal Degeneration (246) · Retinal Diseases (246) · Nervous System Diseases (86) · Pathological Conditions, Signs and Symptoms (73) · Signs and Symptoms (71) · Neurologic Manifestations (61) · Congenital Abnormalities (56) · Sensation Disorders (56) · Abnormalities, Multiple (55) · Ear Diseases (37)
salicylhydroxamic acid (5) · setmelanotide (5) · Intravitreal Injections (4) · Ciliary Neurotrophic Factor (3) · Docosahexaenoic Acids (3) · Minocycline (3) · Vitamin A (3) · retinol acetate (3) · Acetylcysteine (2) · Blood Specimen Collection (2) · Culture Media, Conditioned (2) · Lutein (2) · Ophthalmic Solutions (2) · Valproic Acid (2) · Visual Prosthesis (2)
National Eye Institute (NEI) (13) · Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (11) · Johns Hopkins University (8) · Second Sight Medical Products (6) · Sheba Medical Center (6) · Ankara Universitesi Teknokent (5) · Columbia University (5) · Laboratoires Thea (5) · Nanoscope Therapeutics Inc. (5) · Okuvision GmbH (5) · Retina Implant AG (5) · SparingVision (5) · University Hospital, Strasbourg, France (5) · QLT Inc. (4) · Ray Therapeutics, Inc. (4)
United States (123) · France (44) · Germany (34) · United Kingdom (30) · Canada (18) · China (15) · Italy (13) · Netherlands (13) · Australia (12) · Israel (12) · Brazil (6) · Spain (6) · Switzerland (6) · Turkey (Türkiye) (6) · Austria (5)
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