36 completed, 10 unknown, 5 withdrawn, 4 recruiting. 25 Phase 2, 12 Phase 1, 11 Not applicable, 11 Phase 4, 10 Phase 3.
Follow Verteporfin: new trials by email Literature Review of Verteporfin trials Research Report on Verteporfin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SCARFREE-001: Verteporfin for Scar Prevention Verteporfin Injection, Saline injection - Surgical Scar | Phase 2 | Not yet recruiting | Odense University Hospital | 12 | 2026-10-01 | 2026-10-05 |
| Effect of YAP1-inhibition in Surgical Wounds. NaCl (placebo), Verteporfin Injection - Scar Formation | Phase 1 / Phase 2 | Not yet recruiting | Jöri Pünchera | 24 | 2025-05-08 | 2025-04-25 |
| Photodynamic Therapy of Primary Localized Prostate Cancer With the SpectraCure P18 System Photodynamic Therapy (PDT), Verteporfin Injection - Prostate Cancer | Phase 1 / Phase 2 | Recruiting | SpectraCure AB | 43 | 2025-01-06 | 2026-05-01 |
| Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer Biopsy, Biospecimen Collection, Computed Tomography - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 2 | Active not recruiting | Mayo Clinic | 24 | 2024-12-06 | 2026-06-18 |
| Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction Biospecimen Collection, Computed Tomography, Endobronchial Ultrasound Bronchoscopy - Malignant Solid Neoplasm | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 42 | 2024-10-01 | 2026-04-06 |
| Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy Ranibizumab, Photodynamic laser treatment (PDT), Triamcinolone Acetonide - Exudative Age Related Macular Degeneration | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2023-03-30 | 2024-03-22 | |
| Choroidal Blood Flow in Acute and Chronic Central Serous Chorioretinopathy Verteporfin - Central Serous Chorioretinopathy | Unknown | Helse Stavanger HF | 50 | 2022-10-01 | 2024-03-18 | |
| Comparing Intravitreal Aflibercept Monotherapy vs Aflibercept Combined With Reduced Fluence PDT in PCV Treatment Aflibercept + reduced fluence photodynamic therapy (RF-PDT), Aflibercept + sham reduced fluence photodynamic therapy (RF-PDT) - Polypoidal Choroidal Vasculopathy | Not applicable | Completed | Singapore National Eye Centre | 60 | 2021-02-01 | 2025-11-18 |
| Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma Verteporfin - Glioblastoma, Recurrent Glioblastoma | Phase 1 / Phase 2 | Recruiting | Emory University | 24 | 2021-01-15 | 2025-02-25 |
| Treatment of Polypoidal Choroidal Vasculopathy in Pachychoroid Aflibercept Injection - Choroidal Neovascularization, Choroid Disease | Not applicable | Completed | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | 17 | 2017-09-18 | 2019-09-03 |
| Ultrasound-Guided Verteporfin Photodynamic Therapy for the Treatment of Unresectable Solid Pancreatic Tumors or Advanced Pancreatic Cancer, VERTPAC-02 Study Endoscopic Ultrasound, Fluorescence Imaging, Photodynamic Therapy - Advanced Pancreatic Carcinoma, Locally Advanced Pancreatic Carcinoma | Phase 2 | Completed | Mayo Clinic | 13 | 2017-05-31 | 2025-07-30 |
| Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System Verteporfin, SpectraCure P18 System - Recurrent Prostate Cancer | Phase 1 / Phase 2 | Recruiting | SpectraCure AB | 66 | 2017-03-21 | 2026-05-01 |
| Initial Versus Delayed PDT Combination With Conbercept in PCV conbercept, Initial PDT, Delayed PDT - Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | The Eye Hospital of Wenzhou Medical University | 80 | 2017-01-01 | 2019-07-19 |
| An Open Label, Phase II Trial of Continuous Low-Irradiance Photodynamic Therapy (CLIPT) Using Verteporfin (Visudyne®) for the Treatment of Cutaneous Metastases of Breast Cancer Verteporfin, Continuous Low-Irradiance Photodynamic Therapy (CLIPT) - Metastatic Breast Cancer | Phase 2 | Unknown | Rogers Sciences Inc. | 15 | 2016-10-01 | 2018-07-20 |
| Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD Aflibercept, Triamcinolone Acetonide, Verteporfin - Neovascular Age-related Macular Degeneration | Not applicable | Withdrawn | Duke University | 2016-01-01 | 2017-07-26 | |
| Photo-induction as a Means to Improve Cisplatin Delivery to Pleural Malignancies Cisplatin, liposomal, Verteporfin, Device for Intrapleural Visudyne-mediated Low-Dose Photodynamic Therapy with integrated in situ light dosimetry - Pleural Effusion, Malignant | Phase 1 | Terminated | Centre Hospitalier Universitaire Vaudois | 1 | 2016-01-01 | 2019-03-20 |
| Cohort Study of the Clinical Course of Macular Diseases in Kagawa ranibizumab, aflibercept, pegaptanib, verteporphin - Macular Disease | Phase 4 | Unknown | Kagawa University | 1000 | 2014-12-01 | 2018-03-07 |
| Aflibercept in Polypoidal Choroidal Vasculopathy Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321), Visudyne - Neovascular Macular Degeneration | Phase 4 | Completed | Bayer | 333 | 2014-05-29 | 2020-12-02 |
| Cohort Study of the Clinical Course of Macular Diseases in Japanese ranibizumab, aflibercept, pegaptanib, verteporphin - Macular Disease | Unknown | Kyoto University, Graduate School of Medicine | 1000 | 2014-03-01 | 2016-09-23 | |
| A Study Testing if Medicine Can Make Pigment Epithelium Detachments Regress and Stabilize the Vision in Eyes Aflibercept, Verteporfin - Macular Degeneration, Retinal Detachment | Not applicable | Terminated | Norwegian University of Science and Technology | 9 | 2014-02-01 | 2015-09-15 |
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Macular Degeneration (32) · Choroidal Neovascularization (15) · Polypoidal Choroidal Vasculopathy (7) · Breast Neoplasms (2) · Central Serous Chorioretinopathy (2) · Cicatrix (2) · Glioblastoma (2) · Pancreatic Neoplasms (2) · Prostatic Neoplasms (2) · Retinal Detachment (2) · Astrocytoma (1) · Brain Neoplasms (1) · Central Nervous System Neoplasms (1) · Choroid Diseases (1) · Choroid Plexus Neoplasms (1)
Manhattan Eye, Ear & Throat Hospital (4) · Novartis (4) · QLT Inc. (3) · Barnes Retina Institute (2) · Bayer (2) · Mayo Clinic (2) · Novartis Pharmaceuticals (2) · SpectraCure AB (2) · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo (1) · Bay Area Retina Associates (1) · California Retina Consultants (1) · Centre Hospitalier Universitaire Vaudois (1) · Chonnam National University Hospital (1) · Duke University (1) · Emory University (1)
United States (27) · Canada (6) · South Korea (5) · China (4) · Italy (4) · Japan (4) · Switzerland (4) · Germany (3) · Hong Kong (3) · Singapore (3) · Taiwan (3) · United Kingdom (3) · Austria (2) · Denmark (2) · Hungary (2)
Akiataka Tsujikawa, MD (1) · Allen Ho, MD (1) · Andrew Strong, Ph.D (1) · Cheng-Kuo Cheng, MD (1) · Chenjin Jin, Ph.D. (1) · Dante J Pieramici, MD (1) · David Callanan, MD (1) · David Hebbelstrup Jensen, MD, Ph.d. (1) · Gaurav K. Shah, MD (1) · Gemmy Cheung Chui Ming (1) · Graeme R. Boniface, PhD (1) · Hamid Ahmadieh, MD (1)
PMID 40522203, PMID 19530976, PMID 21742303, PMID 22424834, PMID 22426346, PMID 22444829, PMID 23410808, PMID 25079064, PMID 25758601, PMID 29801063, PMID 29925341, PMID 33647286, PMID 34261044, PMID 34266844, PMID 35223882, PMID 40146166, PMID 41903075
P01CA084203 (2), 2025 (1), P30CA138292 (1), R01CA283547 (1)