Prevalence and Clinical Characteristics of Age-Related Macular Degeneration Among Elderly Patients Attending Assiut University Hospitals: A Hospital Based Cross Sectional Study.
| Registry | NCT07886177 |
|---|---|
| Status | Not yet recruiting |
| Study type | Observational |
| Enrollment | 90 (Estimated) |
| Sponsor | Assiut University (Other) |
| Conditions | Age-Related Macular Degeneration (AMD) |
| Interventions | OCT - clear (Device) |
| Dates | start 2027-01-01 (estimated), primary completion 2028-09-01 (estimated), completion 2028-09-01 (estimated), first posted 2026-10-21, last updated 2026-10-21 |
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All trials for Age-Related Macular Degeneration (AMD) All trials of OCT - clear
AMD represents an important cause of irreversible visual impairment in the elderly.
Despite its clinical importance, there is limited contemporary epidemiological information regarding AMD among elderly patients in Upper Egypt.
The availability of slit-lamp biomicroscope, dilated fundus examination, fundus photography and optical coherence tomography at Assiut University Hospitals makes it possible to conduct systematic clinical assessment of elderly patients.
Age-related macular degeneration (AMD) is a chronic degenerative macular disorder and an important cause of irreversible visual impairment in older adults. It affects the retinal pigment epithelium, Bruch's membrane and photoreceptor complex, and its clinical spectrum ranges from drusen and pigmentary abnormalities to geographic atrophy and macular neovascularization. AMD is strongly age-related and is influenced by modifiable and non-modifiable factors, particularly smoking, cardiovascular risk factors and genetic susceptibility. The Beckman clinical classification provides a practical framework dividing disease into early, intermediate and late AMD, with late disease comprising geographic atrophy and neovascular AMD. Appropriate assessment of elderly patients includes history, best-corrected visual acuity, dilated fundus examination and retinal imaging when clinically indicated. Contemporary Egyptian epidemiological data remain limited, particularly in Upper Egypt. A 2025 cross-sectional study of 283 elderly residents of geriatric homes in East Cairo reported AMD in 12.7% of participants and described associations with increasing age and several systemic and behavioral factors. However, a geriatric-home population differs from patients attending ophthalmology services, and there are limited data describing AMD among elderly ophthalmic patients in Assiut and Upper Egypt. Assiut University Hospitals serve a large population from Assiut and surrounding governorates and have facilities for standardized ophthalmic examination and macular OCT when indicated. Estimating hospital-based prevalence and documenting the clinical phenotype may provide useful local data for clinical recognition, referral and future epidemiological research. Therefore, this study will assess the prevalence and clinical characteristics of AMD among elderly patients attending Assiut University Hospitals and explore demographic, systemic and ocular factors associated with its presence.
Sex: All, ages: 60 Years to 100 Years
Inclusion Criteria: * • Age ≥60 years. * Attendance at the ophthalmology outpatient clinics during the recruitment period. * Willingness to participate and ability to provide written informed consent. * Ability to undergo the planned ophthalmic examination. Exclusion Criteria: * Macular diseases unrelated to AMD that substantially interfere with AMD assessment, such as diabetic macular edema, macular dystrophy or retinal vein occlusion involving the macula. * Pathologic myopia with macular complications that mimic or obscure AMD. * Major ocular trauma or previous vitreoretinal surgery preventing reliable macular assessment. * Media opacity preventing adequate fundus examination/imaging when retinal assessment cannot subsequently be achieved. * Active ocular infection preventing safe examination. * Other retinal disorders judged by the investigator to make AMD classification unreliable.