15 completed, 6 unknown, 1 recruiting, 1 terminated. 23 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 23 | Completed 15, Unknown 6, Recruiting 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Radiation Toxicity: new trials by email Literature Review of Radiation Toxicity trials Research Report on Radiation Toxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases Bevacizumab, Dexamethasone - Radiation Necrosis, High Grade Glioma (III or IV) | Phase 3 | Recruiting | The Netherlands Cancer Institute | 408 | 2025-06-19 | 2026-07-13 |
| Cicaderma Efficacy vs Standard Care of Sites in Preventing Radiodermatitis in Non-metastatic Breast Cancer Patients cicaderma + simple hygiene rules, Simple hygiene rules and a maximum of one topical treatment - Breast Adenocarcinoma, Radiation Dermatitis | Phase 3 | Unknown | Centre Leon Berard | 248 | 2020-06-06 | 2021-02-04 |
| The Effect of Hyperbaric OxygeN Therapy on brEast Cancer Patients With Late Radiation toxicitY - UMBRELLA HONEY Trial Hyperbaric oxygen therapy - Breast Cancer, Radiation Toxicity | Phase 3 | Completed | UMC Utrecht | 189 | 2019-08-28 | 2025-04-03 |
| Guided Meditation During Radiotherapy. Meditation, Standard of Care - Quality of Life, Relaxation During Radiation Therapy | Phase 3 | Completed | Mayo Clinic | 75 | 2019-06-01 | 2023-11-01 |
| Photobiomodulation for Breast Cancer Radiodermatitis Photobiomodulation - Breast Cancer, Radiodermatitis | Phase 2 / Phase 3 | Completed | AC Camargo Cancer Center | 48 | 2018-09-26 | 2021-08-13 |
| 3DCRT vs. IMRT in Early Breast Cancer 3DCRT - Radiation Toxicity | Phase 3 | Unknown | Jong Hoon Lee | 690 | 2015-05-01 | 2017-06-05 |
| Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer Standard radiation therapy, intensity-modulated radiation therapy - Cervical Cancer, Endometrial Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 289 | 2012-11-01 | 2022-06-15 |
| Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery stereotactic radiosurgery, whole-brain radiation therapy - Cognitive/Functional Effects, Metastatic Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 194 | 2011-07-01 | 2022-09-16 |
| Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer questionnaire administration, gastrointestinal complications management/prevention, quality-of-life assessment - Bladder Cancer, Cervical Cancer | Phase 3 | Unknown | Royal Marsden NHS Foundation Trust | 75 | 2009-01-01 | 2011-07-15 |
| Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors adjuvant therapy, assessment of therapy complications, quality-of-life assessment - Head and Neck Cancer, Ototoxicity | Phase 3 | Unknown | Institute of Cancer Research, United Kingdom | 84 | 2008-08-01 | 2010-10-07 |
| High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery Cetuximab, Carboplatin, Paclitaxel - Lung Cancer, Radiation Toxicity | Phase 3 | Completed | Radiation Therapy Oncology Group | 544 | 2007-11-01 | 2022-06-21 |
| Mometasone Furoate in Preventing Radiation Dermatitis in Patients Undergoing Radiation Therapy to the Breast or Chest Wall for Invasive Breast Cancer or Ductal Carcinoma in Situ mometasone furoate, placebo - Breast Cancer, Dermatologic Complications | Phase 3 | Completed | North Central Cancer Treatment Group | 176 | 2007-08-01 | 2016-08-01 |
| Palifermin in Lessening Oral Mucositis in Patients Undergoing Radiation Therapy and Chemotherapy for Locally Advanced Head and Neck Cancer palifermin, cisplatin, placebo - Head and Neck Cancer, Mucositis | Phase 3 | Terminated | Radiation Therapy Oncology Group | 21 | 2006-07-01 | 2017-12-26 |
| GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer sargramostim, oral salt and soda mouthwash - Head and Neck Cancer, Mucositis Oral | Phase 3 | Completed | Marilyn Dodd | 91 | 2005-06-07 | 2021-07-30 |
| Parotid-Sparing Intensity-Modulated Radiation Therapy Compared With Conventional Radiation Therapy in Treating Patients With Oropharyngeal or Hypopharyngeal Cancer Who Are at High Risk of Radiation-Induced Xerostomia management of therapy complications, radiation therapy - Head and Neck Cancer, Radiation Toxicity | Phase 3 | Unknown | Royal Marsden NHS Foundation Trust | 84 | 2004-01-01 | 2011-03-23 |
| Zinc Sulfate in Preventing Loss of Sense of Taste in Patients Undergoing Radiation Therapy for Head and Neck Cancer zinc sulfate, placebo - Dysgeusia, Head and Neck Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 173 | 2002-05-01 | 2016-07-14 |
| Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemia External Beam Radiation Therapy, Cisplatin, Internal Radiation Therapy - Anemia, Cervical Adenocarcinoma | Phase 3 | Completed | Gynecologic Oncology Group | 114 | 2001-08-01 | 2017-08-09 |
| Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer cevimeline hydrochloride - Head and Neck Cancer, Oral Complications | Phase 3 | Completed | Daiichi Sankyo | 2001-06-01 | 2012-05-16 | |
| Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer vitamin E, donepezil hydrochloride, placebo - Cognitive/Functional Effects, Delirium | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 9 | 2001-02-01 | 2016-07-13 |
| Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer iseganan HCl oral solution, management of therapy complications - Head and Neck Cancer, Oral Complications of Radiation Therapy | Phase 3 | Unknown | National Cancer Institute (NCI) | 2000-12-01 | 2014-10-15 |
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Radiation Injuries (23) · Head and Neck Neoplasms (9) · Breast Neoplasms (3) · Lung Neoplasms (3) · Salivary Gland Neoplasms (3) · Squamous Cell Carcinoma of Head and Neck (3) · Uterine Cervical Neoplasms (3) · Brain Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Drug-Related Side Effects and Adverse Reactions (2) · Endometrial Neoplasms (2) · Esthesioneuroblastoma, Olfactory (2) · Hypopharyngeal Neoplasms (2) · Mouth Neoplasms (2) · Nasopharyngeal Neoplasms (2)
Wounds and Injuries (23) · Neoplasms (20) · Neoplasms by Site (20) · Mouth Diseases (7) · Neoplasms by Histologic Type (7) · Neoplasms, Glandular and Epithelial (7) · Stomatognathic Diseases (7) · Nervous System Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Carcinoma (5) · Chemically-Induced Disorders (4) · Respiratory Tract Diseases (4) · Respiratory Tract Neoplasms (4) · Salivary Gland Diseases (4) · Skin Diseases (4)
Radiotherapy (5) · Carboplatin (2) · Cisplatin (2) · Paclitaxel (2) · Radiotherapy, Intensity-Modulated (2) · sargramostim (2) · Adrenal Cortex Hormones (1) · Albumin-Bound Paclitaxel (1) · Amifostine (1) · Bevacizumab (1) · Brachytherapy (1) · Capsaicin (1) · Cetuximab (1) · Chemotherapy, Adjuvant (1) · Dexamethasone (1)
Radiation Therapy Oncology Group (5) · Alliance for Clinical Trials in Oncology (4) · Royal Marsden NHS Foundation Trust (2) · AC Camargo Cancer Center (1) · Centre Leon Berard (1) · Daiichi Sankyo (1) · Gynecologic Oncology Group (1) · Institute of Cancer Research, United Kingdom (1) · Jong Hoon Lee (1) · Marilyn Dodd (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1) · North Central Cancer Treatment Group (1) · The Netherlands Cancer Institute (1) · UMC Utrecht (1)
United States (14) · Canada (5) · United Kingdom (3) · Netherlands (2) · Brazil (1) · France (1) · Hong Kong (1) · Singapore (1) · South Korea (1)
Aminah Jatoi, MD (2) · Benjamin Movsas, MD (2) · Chris Nutting (2) · Alex A. Adjei, MD, PhD (1) · Ann Klopp, MD, PhD (1) · Arthur William Blackstock, MD (1) · David I. Rosenthal, MD (1) · Dieta Brandsma, MD, PhD (1) · Francis G. LeVeque, DDS (1) · George Blumenschein, MD (1) · Gillian Thomas (1) · Glauco Baiocchi, MD, PhD (1) · Gregory A. Masters, MD (1) · Guy J. F. Juillard, MD (1) · Hak Choy, MD (1)
PMID 11917283, PMID 15480814, PMID 15800308, PMID 16015544, PMID 17293228, PMID 17394940, PMID 18501528, PMID 19332518, PMID 19596158, PMID 19858383, PMID 20800381, PMID 20888137, PMID 21236730, PMID 22580119, PMID 23477890, PMID 25601342, PMID 26606200, PMID 28687377, PMID 29989857, PMID 31104905, PMID 31841363, PMID 32980384, PMID 33246494, PMID 35960897, PMID 36264568, PMID 36436615, PMID 36472389, PMID 36738929, PMID 36842666, PMID 37441546, PMID 38329746, PMID 38935373
P30CA016042 (1), R01CA107080 (1), U10CA027469 (1)