17 completed. 17 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Completed 17 |
| Phase 2 | 3 | Completed 3 |
Follow PTSD: new trials by email Literature Review of PTSD trials Research Report on PTSD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD 3,4-methylenedioxymethamphetamine (MDMA), Brief Cognitive Behavioral Conjoint Therapy (bCBCT) - PTSD, Relational Problems | Phase 3 | Completed | Dr. Leslie Morland | 16 | 2023-10-06 | 2025-12-08 |
| Glecaprevir/Pibrentasvir for the Treatment of PTSD Glecaprevir / Pibrentasvir Pill - PTSD | Phase 2 / Phase 3 | Completed | White River Junction Veterans Affairs Medical Center | 10 | 2023-04-01 | 2024-08-29 |
| A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD Midomafetamine HCl - PTSD | Phase 3 | Completed | Resilient Pharmaceuticals | 87 | 2021-03-08 | 2025-06-06 |
| Estrogen and Fear in PTSD Estradiol, Placebo oral tablet, Prolonged Exposure (PE) therapy - PTSD | Phase 3 | Completed | The University of Texas Health Science Center, Houston | 83 | 2020-06-24 | 2026-01-09 |
| Epigenetics and MDMA-Assisted Psychotherapy for PTSD MDMA, Psychotherapy - PTSD | Phase 3 | Completed | University of Southern California | 45 | 2018-11-20 | 2026-05-04 |
| A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD TNX-102 SL 5.6 mg - PTSD | Phase 3 | Completed | Tonix Pharmaceuticals, Inc. | 93 | 2018-04-19 | 2025-02-05 |
| Ketamine Infusion for Comorbid PTSD and Chronic Pain A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms. - PTSD, Chronic Pain | Phase 3 | Completed | VA Ann Arbor Healthcare System | 41 | 2018-01-09 | 2020-12-22 |
| Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD Pregabalin plus BBCET, Placebo plus BBCET - PTSD, Alcohol Use Disorder | Phase 3 | Completed | University of Maryland, Baltimore | 57 | 2017-07-07 | 2024-03-13 |
| The Effect of BAT Versus Mixed Physical Activity as add-on Treatment for Traumatised Refugees. Control, Basic Body Awareness Therapy, Mixed physical activity - PTSD, Depression | Phase 3 | Completed | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 338 | 2013-09-01 | 2016-04-29 |
| Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder CBCT for PTSD, Prolonged Exposure - PTSD, Marital Relationship | Phase 3 | Completed | Toronto Metropolitan University | 64 | 2011-11-01 | 2016-10-07 |
| Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD prazosin, placebo - PTSD, Sleep Disorders | Phase 3 | Completed | VA Office of Research and Development | 304 | 2010-01-06 | 2018-05-01 |
| Women Overcoming and Managing Adversity Now (WOMAN) Study TARGET, SGT - Posttraumatic Stress Disorder, PTSD | Phase 2 / Phase 3 | Completed | UConn Health | 108 | 2009-01-01 | 2011-03-29 |
| Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence modified CPT-C - Alcohol Dependence, PTSD | Phase 2 / Phase 3 | Completed | Yale University | 9 | 2008-03-01 | 2016-03-21 |
| Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities Paroxetine - PTSD | Phase 3 | Completed | VA Office of Research and Development | 38 | 2006-10-01 | 2018-07-02 |
| The Efficacy of KIDNET in the Treatment of Traumatized Refugee Children in Germany KIDNET - PTSD | Phase 3 | Completed | University of Konstanz | 25 | 2003-12-01 | 2007-11-16 |
| Divalproex Sodium in the Treatment of PTSD (Post-Traumatic Stress Disorder) Divalproex, placebo - PTSD | Phase 3 | Completed | VA Office of Research and Development | 101 | 2003-10-01 | 2015-10-21 |
| Naltrexone & SSRI in Alcoholics With Depression/PTSD paroxetine, desipramine, Naltrexone - Alcoholism, Depression | Phase 3 | Completed | Yale University | 88 | 2001-10-01 | 2016-02-05 |
Stress Disorders, Post-Traumatic (17) · Alcoholism (3) · Depression (2) · Anxiety Disorders (1) · Chronic Pain (1) · Hepatitis C (1) · Pain (1) · Parasomnias (1) · Sleep Wake Disorders (1)
Mental Disorders (17) · Stress Disorders, Traumatic (17) · Trauma and Stressor Related Disorders (17) · Alcohol-Related Disorders (3) · Chemically-Induced Disorders (3) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Substance-Related Disorders (3) · Behavior (2) · Behavioral Symptoms (2) · Blood-Borne Infections (1) · Communicable Diseases (1) · Digestive System Diseases (1) · Flaviviridae Infections (1)
N-Methyl-3,4-methylenedioxyamphetamine (2) · Paroxetine (2) · Desipramine (1) · Estradiol (1) · Naltrexone (1) · Prazosin (1) · Pregabalin (1) · Psychotherapy (1) · Therapeutics (1) · Valproic Acid (1) · glecaprevir (1) · glecaprevir and pibrentasvir (1) · pibrentasvir (1) · vivitrol (1)
VA Office of Research and Development (3) · Yale University (2) · Dr. Leslie Morland (1) · Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital (1) · Resilient Pharmaceuticals (1) · The University of Texas Health Science Center, Houston (1) · Tonix Pharmaceuticals, Inc. (1) · Toronto Metropolitan University (1) · UConn Health (1) · University of Konstanz (1) · University of Maryland, Baltimore (1) · University of Southern California (1) · VA Ann Arbor Healthcare System (1) · White River Junction Veterans Affairs Medical Center (1)
United States (15) · Canada (1) · Denmark (1) · Germany (1) · Israel (1)
Bradley V Watts, MD, MPH (1) · Candice M Monson, PhD (1) · Ismene L Petrakis, MD (1) · Ismene Petrakis, M.D. (1) · Julian D Ford, Ph.D. (1) · Leslie Morland (1) · Lori Lynne Davis, MD AB (1) · Maja Sticker Nordbrandt, MD (1) · Martina Ruf, Dipl.-Psych. (1) · Mohammed R Milad, PhD (1) · Murray A. Raskind, MD (1) · Rael Cahn, MD, PhD (1) · Thomas Elbert, Prof. Dr. (1) · Zhewu Wang, MD (1)
PMID 18204347, PMID 22089316, PMID 26492879, PMID 29414272, PMID 32163509, PMID 34291990, PMID 36815187, PMID 38113919, PMID 38994348, PMID 40483726
R01AA024760 (1), R33MH111907 (1)