40 completed, 12 recruiting, 8 unknown, 3 not yet recruiting. 19 Not applicable, 8 Phase 2, 7 Phase 3, 6 Phase 4, 3 Phase 1.
Follow Primary Hyperparathyroidism: new trials by email Literature Review of Primary Hyperparathyroidism trials Research Report on Primary Hyperparathyroidism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NIRAF-camera Versus Conventional Surgery in Preoperative Imaging Negative Primary Hyperparathyroidism NIRAF-camera - Primary Hyperparathyroidism | Not applicable | Recruiting | The Cleveland Clinic | 80 | 2026-08-31 | 2026-09-11 |
| Shortwave Infrared Surgical Imaging Device Study Observational study of SWIR imaging device in surgery - Cholecystitis, Cholecystitis, Chronic | Enrolling by invitation | Cision Vision, Inc. | 50 | 2026-05-29 | 2026-08-04 | |
| Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors 18F-FCH, NeuroEXPLORER - Primary Hyperparathyroidism, Parathyroid Cancer | Phase 2 / Phase 3 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 193 | 2026-04-16 | 2026-06-02 |
| Aldosterone Variations in Patients With Primary Hyperparathyroidism After Surgery Primary Hyperparathyroidism, Primary Hyperparathyroidism Due to Adenoma | Not yet recruiting | Central Hospital, Nancy, France | 400 | 2026-02-01 | 2026-02-05 | |
| Evaluation of the Role of Luteinizing Hormone (LH) and Human Chorionic Gonadotropin (hCG) in Adult Patients Undergoing Assessment for Endocrine Disorders Osteoporosis, Hypercalcemia | Recruiting | Martin Blomberg Jensen | 20000 | 2026-01-01 | 2026-09-17 | |
| Is Intraoperative PTH Monitoring Obsolete in Times of Choline PET/CT? a Prospective Multicenter Cohort Study to Determine Whether the Regular Preoperative Use of Choline-PET/CT Scan Obviate the Need for Intraoperative PTH-measurement in Patients with Primary Hyperparathyreoidism Primary Hyperparathyroidism | Not yet recruiting | University of Zurich | 1000 | 2025-09-01 | 2025-02-03 | |
| Bisphosphonate Prior to Parathyroidectomy in Primary Hyperparathyroidism Zoledronic acid 4 mg, Natriumklorid 9 mg/ml, Fresenius Kabi - Primary Hyperparathyroidism | Phase 4 | Recruiting | University of Aarhus | 140 | 2025-03-01 | 2026-10-01 |
| Diagnostic Performance of [11C]Choline PET/CT In the Preoperative Assessment of Primary Hyperparathyroidism PET/CT - Primary Hyperparathyroidism | Not yet recruiting | IRCCS San Raffaele | 200 | 2025-01-01 | 2024-10-22 | |
| Upfront Ultrasound for Preoperative Localization in Primary Hyperparathyroidism Primary Hyperparathyroidism | Completed | Odense University Hospital | 99 | 2023-09-01 | 2026-01-14 | |
| Parathyroid Tumor Clonal Status Parathyroid Tumor, Primary Hyperparathyroidism | Recruiting | Washington University School of Medicine | 839 | 2023-07-28 | 2026-05-12 | |
| Glycemic Control, Type II Diabetes, Parathyroidectomy Urine and Blood Test - Primary Hyperparathyroidism, Type 2 Diabetes | Active not recruiting | The Cleveland Clinic | 80 | 2023-02-27 | 2026-05-26 | |
| 18F-choline Positron-emission-tomography - Computed-tomography Compared to Conventional Imaging for Localizing Diseased Parathyroid Glands in Primary Hyperparathyroidism Parathyroidectomy - Primary Hyperparathyroidism | Not applicable | Recruiting | Region Skane | 88 | 2023-01-01 | 2025-08-24 |
| Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract | Recruiting | Universidad Nacional Autonoma de Mexico | 750 | 2022-08-03 | 2024-07-26 | |
| Object Assessment of Improvement in Non-Specific Symptoms After Parathyroidectomy for Primary Hyperparathyroidism Activity Tracker (Fitbit), HbA1C, The PROMPT Questionnaire - Primary Hyperparathyroidism, Multinodular Goiter | Completed | The Cleveland Clinic | 45 | 2022-07-19 | 2024-08-06 | |
| Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy PTeye, Standard of Care - Parathyroid Adenoma, Parathyroid Neoplasms | Not applicable | Completed | University of Michigan | 160 | 2021-12-01 | 2025-08-27 |
| Natural History Study of Parathyroid Disorders Parathyroid Cancer, Primary Hyperparathyroidism | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 3000 | 2021-11-30 | 2026-09-17 | |
| Gait and Balance Parameters Before and After Parathyroidectomy in Patients With Primary Hyperparathyroidism gait analysis - Primary Hyperparathyroidism | Not applicable | Completed | Recep Tayyip Erdogan University Training and Research Hospital | 40 | 2021-10-17 | 2023-12-05 |
| Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy NIRAF Detection Technology - Parathyroid Adenoma, Parathyroid Neoplasms | Not applicable | Completed | Vanderbilt-Ingram Cancer Center | 160 | 2020-03-13 | 2024-05-13 |
| Preoperative Localization Strategies in Primary Hyperparathyroidism Contrast-enhanced ultrasound - Primary Hyperparathyroidism | Not applicable | Completed | Odense University Hospital | 172 | 2019-09-05 | 2022-04-14 |
| Calcitonin Pre-treatment to Improve SPECT-CT Sensitivity Calcitonin - Primary Hyperparathyroidism, Hypercalcemia | Phase 4 | Recruiting | Joseph Sferra | 37 | 2019-05-29 | 2024-09-19 |
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Hyperparathyroidism, Primary (69) · Parathyroid Neoplasms (13) · Hypercalcemia (9) · Bone Diseases, Metabolic (6) · Osteoporosis (6) · Hyperparathyroidism (5) · Vitamin D Deficiency (4) · Multiple Endocrine Neoplasia Type 1 (3) · Thyroid Diseases (3) · Osteoporosis, Postmenopausal (2) · Parathyroid Diseases (2) · Acromegaly (1) · Adenoma, Islet Cell (1) · Adrenal Gland Diseases (1) · Atherosclerosis (1)
Endocrine System Diseases (68) · Parathyroid Diseases (67) · Hyperparathyroidism (64) · Metabolic Diseases (20) · Nutritional and Metabolic Diseases (20) · Neoplasms (15) · Endocrine Gland Neoplasms (14) · Neoplasms by Site (14) · Head and Neck Neoplasms (13) · Musculoskeletal Diseases (12) · Bone Diseases (11) · Calcium Metabolism Disorders (10) · Water-Electrolyte Imbalance (9) · Avitaminosis (4) · Bone Diseases, Metabolic (4)
Cinacalcet (6) · Cholecalciferol (4) · Parathyroidectomy (4) · Denosumab (3) · Vitamin D (3) · Zoledronic Acid (2) · Alendronate (1) · Amiloride (1) · Calcitonin (1) · Calcium (1) · Calcium Carbonate (1) · Congresses as Topic (1) · Eplerenone (1) · Fitness Trackers (1) · Gait Analysis (1)
Columbia University (5) · The Cleveland Clinic (3) · University of Aarhus (3) · Amgen (2) · Assistance Publique - Hôpitaux de Paris (2) · Central Hospital, Nancy, France (2) · HaEmek Medical Center, Israel (2) · Karolinska University Hospital (2) · Kyowa Kirin Co., Ltd. (2) · M.D. Anderson Cancer Center (2) · Medical University of Vienna (2) · Nantes University Hospital (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Odense University Hospital (2) · Region Skane (2)
United States (23) · Denmark (8) · France (7) · Sweden (5) · Austria (2) · Israel (2) · Italy (2) · Japan (2) · Switzerland (2) · Canada (1) · China (1) · Czechia (1) · India (1) · Mexico (1) · Norway (1)
Bruno Niederle, Prof., MD (2) · Judy Jin, MD (2) · Shonni J Silverberg, MD (2) · Smita Jha, M.D. (2) · Adrienne Brouwers, MD PhD (1) · Anand Vaidya, MD MMSc (1) · Anders Bergenfelz, MD, Ass Prof (1) · Anders OJ Bergenfelz, MD, PhD (1) · Arturo Chiti, MD (1) · Carmen C Solorzano, MD, FACS (1) · Constantin Ungureanu, MD (1) · Don Wilson, MD, FRCPC (1) · Donald W Anderson, MD, FRCSC (1)
PMID 40668552, PMID 10898180, PMID 15663056, PMID 16540904, PMID 16785355, PMID 17071309, PMID 17216827, PMID 17284629, PMID 17879694, PMID 19160424, PMID 19351725, PMID 19950385, PMID 20035529, PMID 21044114, PMID 21679561, PMID 24026893, PMID 24115138, PMID 25414430, PMID 25636048, PMID 25975331, PMID 26031271, PMID 26435425, PMID 28522130, PMID 30860588, PMID 31595982, PMID 32333877, PMID 33585500, PMID 35018442, PMID 35138562, PMID 35436153, PMID 36917123, PMID 37052913, PMID 37284613, PMID 37288292, PMID 37339334, PMID 37597095, PMID 38174154, PMID 39189547, PMID 39946193, PMID 41486083, PMID 42484783, PMID 42620272, PMID 42817602
R01CA212147 (2), R01DK032333 (2), R01DK084986 (2), 2008 (1), 2016 (1), 2018 (1), 2023 (1), P30CA016672 (1), R01DK066329 (1)