32 completed, 9 not yet recruiting, 9 recruiting, 9 unknown. 38 Not applicable, 5 Phase 2, 3 Phase 1, 1 Early Phase 1, 1 Phase 3.
Follow Presbycusis: new trials by email Literature Review of Presbycusis trials Research Report on Presbycusis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| First In Human Randomised Trial of Rincell-1 in Adults With a Cochlear Implant Otic neural progenitors, cochlear implantation - Sensorineural Hearing Loss, Presbyacusis | Phase 1 / Phase 2 | Not yet recruiting | Rinri Therapeutics | 20 | 2027-09-01 | 2026-10-01 |
| HEARS Maryland: Extending Capacity for Affordable, Accessible Hearing Care Through Older Adult Peer Mentorship HEARS MD Device, HEARS MD Program - Hearing Loss, Hearing Impairment | Not applicable | Not yet recruiting | Johns Hopkins University | 300 | 2026-11-30 | 2026-07-29 |
| Optimizing Elderly Hearing Loss Care in Hong Kong A Cost-Effectiveness and Satisfactory Analysis of a Pilot Collaborative Model Between Otorhinolaryngologists and Family Medicine Specialists Hearing Loss, Age-Related, Presbycusis | Not yet recruiting | Tseung Kwan O Hospital, Hong Kong | 500 | 2026-09-01 | 2026-08-24 | |
| Hidden Hearing Loss in Older Adults Hidden Hearing Loss | Recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 200 | 2026-06-15 | 2026-06-12 | |
| Prediction of Age-Related Hearing Loss Based on Comprehensive Risk Factors Not applicable- observational study - Age-related Hearing Loss | Not yet recruiting | Chinese PLA General Hospital | 1000 | 2026-06-01 | 2026-05-29 | |
| Management of Age-Related Auditory Decline and Early Warning of Its Co-occurring Dementia Not applicable- observational study - Age-related Hearing Loss, Dementia | Not yet recruiting | Chinese PLA General Hospital | 3000 | 2026-05-25 | 2026-05-27 | |
| First Clinical Study to Evaluate Safety, Tolerability & PK of DX243 in Healthy Volunteers and Patients With Hearing Loss DX243, Placebo - Age-related Hearing Loss | Phase 2 | Recruiting | Dendrogenix | 24 | 2026-05-13 | 2026-06-10 |
| Improving Speech in Noise Perception for Individuals With Age-related Hearing Loss transcutaneous auricular vagus nerve stimulation, Sham Control - Presbycusis | Not applicable | Completed | University of Florida | 36 | 2025-12-01 | 2026-10-20 |
| Communication Training in Hearing Aid Users Cognitive screening, Audiological Assessment, Questionnaires - Hearing Loss, Age-Related, Hearing Aids | Not applicable | Completed | University Ghent | 57 | 2025-09-16 | 2026-09-01 |
| Hearing-physical Activity Intervention hearing-physical activity training - Hearing Loss, Age-Related | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 60 | 2025-09-01 | 2025-07-17 |
| A Clinical Trial of the Safety and Efficacy of TJ0113 Capsules in the Treatment of Patients With Age-related Hearing Loss TJ0113 capsules, Placebo capsules - Age Related Hearing Loss, Deafness | Not applicable | Not yet recruiting | Yilai Shu | 60 | 2025-06-07 | 2025-06-10 |
| Increasing Physical Activity with a Social Robot-assisted Exercise Intervention in Older Adults with Hearing Loss: a Feasibility and Pilot Randomized Controlled Trial A social robot KaKa-assisted intervention - Age-related Hearing Loss | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 40 | 2025-05-01 | 2025-03-14 |
| Benefits of Choir for Older Adults With Unaddressed Hearing Loss (WP2) Group Singing, Audiobook Club - Hearing Loss, Age-Related, Speech Intelligibility | Not applicable | Recruiting | Toronto Metropolitan University | 210 | 2025-04-15 | 2025-09-18 |
| A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise, Placebo Drug With Engineered Sound - Central Auditory Processing Disorder, Hearing Impaired (Partially) | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 344 | 2025-03-31 | 2026-04-30 |
| Barriers and Facilitators to OTC Hearing Aids Success Audiologist-based fitting, Over-the-counter fitting - Hearing Loss, Sensorineural, Presbycusis | Not applicable | Recruiting | Yu-Hsiang Wu | 360 | 2025-03-15 | 2025-05-21 |
| Hearing Screening in Adults Over 50 Years Old Screening HHIA questionnaire, Whispered voice test, Screening pure tone audiometry - Hearing Loss, Bilateral Sensorineural, Progressive, Hearing Loss, Bilateral (Causes Other Than Tumors) | Not applicable | Enrolling by invitation | University Hospital Hradec Kralove | 330 | 2025-01-01 | 2025-05-30 |
| Cognitive Function and EEG Brain Network Remodeling Among Users of Hearing Aids With ARHL hearing aids - Age-related Hearing Loss, Age-related Cognitive Decline | Active not recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 60 | 2024-12-01 | 2025-03-25 | |
| Comparing the Efficacy of Domestic Versus Imported Hearing Aids in ARHL Domestic hearing aids, Imported hearing aids - Age-related Hearing Loss, Hearing Loss, Sensorineural | Not applicable | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 80 | 2024-10-24 | 2025-08-13 |
| Evaluation of a Digital Therapy of Auditory Training AUDISSEE, Placebo - Hearing Loss, Age-Related | Not applicable | Unknown | Humans Matter | 240 | 2024-09-01 | 2024-02-28 |
| Hearing Healthcare Assessment in Rural Communities Patient Navigation Program for Hearing Health Care - Hearing Loss, Adult-Onset, Hearing Loss, Age-Related | Not applicable | Active not recruiting | Matthew Bush, MD | 500 | 2024-08-08 | 2026-08-20 |
Showing 20 of 66. Sign in to see all of them.
Hearing Loss (24) · Hearing Loss, Sensorineural (12) · Cognitive Dysfunction (7) · Alzheimer Disease (3) · Deafness (3) · Auditory Perceptual Disorders (2) · Dementia (2) · Depression (2) · Frailty (2) · Hearing Disorders (2) · Hearing Loss, Bilateral (2) · Hearing Loss, Hidden (2) · Hearing Loss, Noise-Induced (2) · Hearing Loss, Sudden (2)
Ear Diseases (66) · Neurologic Manifestations (66) · Otorhinolaryngologic Diseases (66) · Pathological Conditions, Signs and Symptoms (66) · Sensation Disorders (66) · Signs and Symptoms (66) · Nervous System Diseases (65) · Hearing Disorders (64) · Hearing Loss, Sensorineural (54) · Hearing Loss (42) · Mental Disorders (15) · Neurocognitive Disorders (14) · Cognition Disorders (9) · Behavior (8) · Brain Diseases (8)
Hearing Aids (5) · AUT00063 (1) · Acoustic Impedance Tests (1) · Audiometry, Pure-Tone (1) · Blood Specimen Collection (1) · Cholinesterase Inhibitors (1) · Clemastine (1) · Cochlear Implantation (1) · Counseling (1) · Cytidine Diphosphate (1) · Genes (1) · Genotype (1) · Hormone Replacement Therapy (1) · Interviews as Topic (1) · Liuwei Dihuang Decoction (1)
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (5) · Yu-Hsiang Wu (4) · The Hong Kong Polytechnic University (3) · Chinese PLA General Hospital (2) · Indiana University (2) · Johns Hopkins University (2) · US Department of Veterans Affairs (2) · University Hospital, Angers (2) · University Hospital, Toulouse (2) · Aalto University (1) · Autifony Therapeutics Limited (1) · Azienda Unita Sanitaria Locale di Piacenza (1) · Centre Hospitalier Universitaire de Nice (1) · Concordia University, Montreal (1) · Dendrogenix (1)
United States (22) · China (10) · France (9) · Belgium (3) · Canada (3) · Hong Kong (2) · United Kingdom (2) · Australia (1) · Austria (1) · Czechia (1) · Finland (1) · Germany (1) · Italy (1) · Netherlands (1) · Norway (1)
Yu-Hsiang Wu, PhD (4) · Achim Klug, PhD (1) · Alan M Letzt, M.S. (1) · Carl LeBel, PhD (1) · Catherine Palmer, PhD (1) · Claude Alain, PhD (1) · Daniel Polley, Ph.D. (1) · David J Werring, Professor (1) · David L. Woods, PhD (1) · Domenico Cuda, MD (1) · Doris-Eva Bamiou, Professor (1) · Douglas Hartley (1) · Esther Oh, MD, Ph.D. (1) · Frank Russo, PhD (1)
PMID 20329860, PMID 20562624, PMID 20665350, PMID 23341320, PMID 28252160, PMID 28269769, PMID 28387664, PMID 30052097, PMID 30575602, PMID 30938563, PMID 33581722, PMID 37342862, PMID 37467243, PMID 37864139, PMID 38861681, PMID 39630812, PMID 40372746, PMID 40910451, PMID 42054294
R01DC015997 (4), 2009 (1), 2023 (1), K23AG065443 (1), K23DC016855 (1), P01AG009524 (1), R01DC010135 (1), R01DC011771 (1), R01DC012289 (1), R21DC020149 (1), R33DC019602 (1), R44AG045947 (1)