20 completed, 17 unknown, 13 not yet recruiting, 7 recruiting. 19 Phase 2, 15 Not applicable, 9 Phase 1, 9 Phase 3, 4 Phase 4.
Follow Hearing Loss, Sudden: new trials by email Literature Review of Hearing Loss, Sudden trials Research Report on Hearing Loss, Sudden
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss Dexamethasone, Hyaluronic acid, Indocyanine green(ICG) - Hearing Loss, Sensorineural, Hearing Loss, Sudden | Phase 1 / Phase 2 | Withdrawn | Seoul National University Hospital | 2026-12-15 | 2026-05-22 | |
| Autologous Circulating Extracellular Vesicles for Total-Type Sudden Sensorineural Hearing Loss autologous circulating extracellular vesicles, Glucocorticoids - Sudden Sensorineural Hearing Loss (SSNHL) | Phase 3 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 146 | 2026-09-15 | 2026-10-16 |
| Efficacy and Safety of Intracochlear Injection of Glucocorticoid Through the Round Window Membrane in Patients With Profound or Complete Sudden Sensorineural Hearing Loss intracochlear injection of triamcinolone acetonide through the round window membrane, intratympanic dexamethasone injection through the tympanic membrane - Sudden Hearing Loss | Phase 2 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 56 | 2026-09-15 | 2026-09-11 |
| CGM-guided Patch Pump vs Basal-Bolus Injection for Steroid-Induced Hyperglycemia in Sudden Sensorineural Hearing Loss: SHIP Trial CareLevo Patch-type Insulin Pump, Insulin Glargine U-100 (Lantus), Fast-acting Insulin Aspart (Fiasp) - Sudden Sensorineural Hearing Loss (SSNHL), Prediabetes / Type 2 Diabetes | Not applicable | Not yet recruiting | Hallym University | 50 | 2026-08-01 | 2026-07-22 |
| Trans-round Window Membrane Intracochlear Steroid Experimental: Group A: intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone, intratympanic dexamethasone injection - Sudden Hearing Loss | Phase 2 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 108 | 2026-04-20 | 2026-04-20 |
| Acupuncture Therapy for Sudden Sensorineural Hearing Loss Acupuncture, Sham acupuncture - Sudden Sensorineural Hearing Loss (SSNHL) | Not applicable | Recruiting | Eye & ENT Hospital of Fudan University | 256 | 2026-04-13 | 2026-05-08 |
| Effect of Aspirin and Folic Acid for Sudden Sensorineural Hearing Loss Aspirin + Acid folic, Placebo Aspirin + Placebo Acid folic - Sudden Sensorineural Hearing Loss | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 142 | 2026-04-01 | 2026-01-14 |
| Regenerative Medicine and Stem Cell-Based Interventions for Inner Ear Trauma, Tinnitus, and Sensorineural Hearing Loss Audiologic Monitoring, Investigational Regenerative Pharmacologic Therapy, Stem Cell Regenerative Therapy - Sensorineural Hearing Loss, Tinnitus | Early Phase 1 | Enrolling by invitation | Truway Health, Inc. | 120 | 2026-03-08 | 2026-03-16 |
| Study on the Safety and Efficacy of Intratympanic Injection of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells in Severe and Profound Sudden Sensorineural Hearing Loss Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at low doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at moderate doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at high doses - Sudden Hearing Loss, Extracellular Vesicles | Phase 1 / Phase 2 | Not yet recruiting | The Affiliated Hospital of Qingdao University | 9 | 2026-02-28 | 2026-03-25 |
| Yiyuancong for the Treatment of Sudden Sensorineural Hearing Loss Standard treatment combined with Yiyuancong, Standard treatment - Sudden Hearing Loss, Sensorineural Hearing Loss | Not applicable | Recruiting | Guangdong Provincial People's Hospital | 128 | 2025-11-15 | 2026-04-01 |
| Evaluation of Oral Corticosteroid Therapy in Idiopathic Sudden Unilateral Hearing Loss. prednisone - oral corticosteroid 1mg/kg/D for 1 week, Placebo - Sudden Sensorineural Hearing Loss | Phase 3 | Not yet recruiting | Centre Hospitalier Universitaire de Besancon | 430 | 2025-11-01 | 2025-07-24 |
| Intracochlear Injection of Glucocorticoid intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone through the round window membrane, intracochlear dexamethasone injection and intratympanic dexamethasone injection - Sudden Sensorineural Hearing Loss (SSNHL) | Phase 2 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 150 | 2025-08-25 | 2025-08-21 |
| Effect of Hyperbaric Oxygen Therapy(HBOT) on Patients With Sudden Sensorineural Hearing Loss(SSNHL) and Coagulation Function Hyperbaric oxygen treatment - Sudden Sensorineural Hearing Loss (SSNHL), Hyperbaric Oxygen Therapy | Not yet recruiting | Sun Yuting | 1309 | 2025-06-01 | 2025-05-14 | |
| 'Inner Ear Support' Oral Capsule in Patients With Sudden Sensorineural Hearing Loss Inner ear support - Sudden Sensorineural Hearing Loss (SSNHL), Tinnitus | Not applicable | Not yet recruiting | Far East Bio-Tec Co., Ltd | 80 | 2025-06-01 | 2025-05-30 |
| Intratympanic Injection of Dexamethasone With Hyaluronic Acid in Treatment of Sudden Sensorineural Hearing Loss Hyaluronic Acid (HA), Dexamethasone - Sudden Sensorineural Hearing Loss (SSNHL) | Phase 4 | Not yet recruiting | Assiut University | 70 | 2025-05-01 | 2025-03-17 |
| Comparison of the Effectiveness of Oral and Intratympanic Corticosteroid Treatments in Patients Diagnosed With Sudden Sensorineural Hearing Loss Methylprednisolone (drug), Dexamethasone - Sudden Sensorineural Hearing Loss | Phase 4 | Recruiting | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 214 | 2024-12-25 | 2026-09-01 |
| Autologous Blood Monocyte Vesicles for the Treatment of Sudden Deafness autologous blood monocyte vesicles (lower dose), Methylprednisolone, autologous blood monocyte vesicles (higher dose) - Sudden Deafness, Sensorineural Hearing Loss | Early Phase 1 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 30 | 2024-12-25 | 2024-12-27 |
| Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss Hydroxychloroquine, Steroid - Sudden Hearing Loss | Phase 2 | Recruiting | Chang Gung Memorial Hospital | 80 | 2024-09-10 | 2026-10-22 |
| Effectiveness of Integrative Medical Treatment in Sudden Hearing Loss Acupuncture, steroid therapy - Sudden Hearing Loss | Not applicable | Recruiting | China Medical University Hospital | 64 | 2024-07-08 | 2025-11-19 |
| Multi-omics Characteristics and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss Sudden Sensorineural Hearing Loss, Hearing Loss, Sensorineural | Not yet recruiting | Dan Bing | 400 | 2024-04-23 | 2024-04-15 |
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Hearing Loss, Sensorineural (14) · Hearing Loss (8) · Hearing Loss, Noise-Induced (7) · Meniere Disease (6) · Tinnitus (5) · Labyrinth Diseases (2) · Labyrinthitis (2) · Presbycusis (2) · Sleep Apnea, Obstructive (2) · Blast Injuries (1) · Cochlear Diseases (1) · Deafness (1) · Diabetes Mellitus, Type 2 (1) · Hearing Loss, Hidden (1)
Ear Diseases (65) · Hearing Disorders (65) · Nervous System Diseases (65) · Neurologic Manifestations (65) · Otorhinolaryngologic Diseases (65) · Pathological Conditions, Signs and Symptoms (65) · Sensation Disorders (65) · Signs and Symptoms (65) · Hearing Loss (57) · Labyrinth Diseases (8) · Endolymphatic Hydrops (6) · Hearing Loss, Sensorineural (3) · Apnea (2) · Dyssomnias (2) · Otitis (2)
Dexamethasone (7) · Methylprednisolone (6) · Hyaluronic Acid (3) · Prednisone (3) · Acupuncture Therapy (2) · Fumigant 93 (2) · Interleukin 1 Receptor Antagonist Protein (2) · Methylprednisolone Hemisuccinate (2) · Pharmaceutical Preparations (2) · Anesthesia, Local (1) · Aspirin (1) · Bed Rest (1) · Calcium Dobesilate (1) · Cochlear Implantation (1) · D-JNKI-1 (1)
Eye & ENT Hospital of Fudan University (6) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (5) · Frequency Therapeutics (4) · Tel-Aviv Sourasky Medical Center (3) · Andrea Vambutas (2) · Assiut University (2) · Chang Gung Memorial Hospital (2) · Seoul National University Hospital (2) · Yuzuncu Yil University (2) · Assistance Publique - Hôpitaux de Paris (1) · Auris Medical AG (1) · Beijing Tsinghua Chang Gung Hospital (1) · Carmel Medical Center (1) · Centre Hospitalier Universitaire de Besancon (1) · China Medical University Hospital (1)
China (18) · United States (12) · France (6) · Taiwan (4) · Germany (3) · Israel (3) · South Korea (3) · Turkey (Türkiye) (3) · Egypt (2) · Austria (1) · Bulgaria (1) · Canada (1) · Czechia (1) · Italy (1) · Serbia (1)
Carl LeBel, PhD (4) · Yilai Shu, MD, Ph.D (3) · Andrea Vambutas, MD (2) · Huawei Li, MD, Ph.D (2) · Busheng Tong, doctor (1) · Chao-Hui Yang (1) · Daniel Sun, MD (1) · Dong Pin, Doctor (1) · Donna Whitlon, Ph.D. (1) · Eldar Carmel, MD (1) · Eli Zuckerman, M.D. (1) · Gavin C Solomon, CEO (1) · Haidi Yang, Doctor (1)
PMID 25133431, PMID 15189754, PMID 19172627, PMID 21610239, PMID 21859903, PMID 22805100, PMID 25712982, PMID 26648996, PMID 27769665, PMID 28261890, PMID 31369359, PMID 31498290, PMID 32698830, PMID 33895732, PMID 36103419, PMID 36602041, PMID 37517037, PMID 38532282, PMID 40444483, PMID 41035311, PMID 41358892
R33DC011827 (2), 2009 (1), U01DC006296 (1)