191 completed, 83 unknown, 64 recruiting, 29 not yet recruiting. 121 Not applicable, 34 Phase 4, 29 Phase 3, 21 Phase 2, 12 Early Phase 1.
Follow Preeclampsia: new trials by email Literature Review of Preeclampsia trials Research Report on Preeclampsia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention Clinician notification of elevated preeclampsia risk - Preeclampsia, Hypertensive Disorders of Pregnancy (HDP) | Not applicable | Not yet recruiting | Massachusetts General Hospital | 1000 | 2027-05-01 | 2026-05-29 |
| Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders Ravulizumab - Preeclampsia | Phase 2 | Recruiting | Mayo Clinic | 14 | 2027-04-01 | 2026-10-22 |
| Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography Transthoracic Echocardiography - Preeclampsia | Suspended | Brigham and Women's Hospital | 80 | 2026-10-25 | 2026-01-20 | |
| Vagal Stimulation Therapy and Preeclampsia Vagal stimulation physiotherapy with trigger point release, Positional Release Therapy - Gestational Hypertension, Preeclampsia | Not applicable | Recruiting | Fundación Internacional René Mey | 210 | 2026-10-15 | 2026-09-02 |
| Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in Preeclampsia Dexamethasone, Ondansetron - Preeclampsia, Spinal Anesthesia-Induced Hypotension | Phase 4 | Not yet recruiting | Assiut University | 110 | 2026-10-01 | 2026-08-31 |
| Use of Allied-health Professionals to Improve Treatment of Disease Research Pharmacist - Preeclampsia | Not applicable | Not yet recruiting | University of Iowa | 200 | 2026-10-01 | 2026-06-04 |
| Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities Care coordination, Electronic massage, support gift #1 - Preterm Birth Complication, Preterm Birth | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 1228 | 2026-10-01 | 2026-09-29 |
| Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes Measurement of plasma nucleosome and placental growth factor (PLGF) levels - Preeclampsia, Premature Birth | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 900 | 2026-09-20 | 2026-09-25 | |
| Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period. Education, Blood Pressure Cuff, and Visual Cue Bracelet - Preeclampsia, Gestational Hypertension | Not applicable | Not yet recruiting | Memorial Hermann Health System | 40 | 2026-09-16 | 2026-09-08 |
| Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study None (this is an observational study with no intervention) - GDM, Preterm Preeclampsia | Recruiting | Medicines360 | 5500 | 2026-09-08 | 2026-09-30 | |
| Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy Natural Non-Alkalized Cocoa, Polyphenol-Rich Dietary Counseling - Pregnancy, Gestational Diabetes Mellitus (GDM) | Not applicable | Not yet recruiting | University of Salamanca | 60 | 2026-09-01 | 2026-06-18 |
| Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth Handstimulation of breast - Preterm Birth, PPROM | Not applicable | Not yet recruiting | Odense University Hospital | 250 | 2026-09-01 | 2025-09-24 |
| Identification of Genes of Interest for Severe Forms of Preeclampsia Preeclampsia, Severe Preeclampsia | Not yet recruiting | University Hospital, Strasbourg, France | 100 | 2026-09-01 | 2026-07-14 | |
| Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor - Pregnancy-Associated Hypertension, Gestational Hypertension | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 174 | 2026-08-31 | 2026-08-24 |
| Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia Paroxetine Hydrochloride, Ascorbic acid (Vitamin C) - Preeclampsia, Endothelial Function | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 40 | 2026-08-30 | 2026-07-29 |
| Progesterone Preeclampsia Progesterone supplementation - Preeclampsia, Hypertensive Disorder of Pregnancy | Phase 4 | Recruiting | Medical University of South Carolina | 642 | 2026-08-13 | 2026-08-17 |
| The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health 'Standard of Care PLUS' - Preterm Birth, Preeclampsia | Not applicable | Not yet recruiting | GrowBaby Life Project | 500 | 2026-08-01 | 2026-04-30 |
| Mechanistic Underpinnings of Preeclampsia Preeclampsia | Not yet recruiting | University of Arizona | 500 | 2026-07-25 | 2025-11-26 | |
| Mobile Health Program for Post-Preeclampsia Hypertension Coaching application, Home-based blood pressure monitoring, WebMD - Hypertension (HTN), Preeclampsia | Not applicable | Recruiting | University of Pittsburgh | 50 | 2026-07-22 | 2026-07-29 |
| Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy Decision aid - Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy | Not applicable | Recruiting | University of Utah | 30 | 2026-07-15 | 2026-06-23 |
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Pre-Eclampsia (416) · Hypertension, Pregnancy-Induced (52) · Hypertension (37) · Premature Birth (34) · Fetal Growth Retardation (33) · Pregnancy Complications (28) · Diabetes, Gestational (21) · Eclampsia (17) · Toxemia (15) · HELLP Syndrome (12) · Obesity (11) · Proteinuria (11) · Cardiovascular Diseases (10) · Anxiety Disorders (6) · Birth Weight (6)
Female Urogenital Diseases and Pregnancy Complications (416) · Urogenital Diseases (416) · Pregnancy Complications (388) · Hypertension, Pregnancy-Induced (364) · Vascular Diseases (88) · Pathological Conditions, Signs and Symptoms (86) · Cardiovascular Diseases (81) · Pathologic Processes (54) · Obstetric Labor Complications (45) · Hypertension (43) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (38) · Nutritional and Metabolic Diseases (36) · Signs and Symptoms (35) · Fetal Diseases (33) · Growth Disorders (33)
Aspirin (31) · Labetalol (7) · Blood Specimen Collection (6) · Magnesium Sulfate (6) · Nifedipine (5) · Ascorbic Acid (4) · Metformin (4) · Pregnancy (4) · Cholecalciferol (3) · Control Groups (3) · Echocardiography (3) · Enoxaparin (3) · Ephedrine (3) · Esomeprazole (3) · Folic Acid (3)
Assistance Publique - Hôpitaux de Paris (8) · Assiut University (8) · Cairo University (8) · Gynuity Health Projects (8) · Ohio State University (7) · Oslo University Hospital (7) · Anna Stanhewicz, PhD (6) · Cengiz Gokcek Women's and Children's Hospital (5) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (5) · Instituto Materno Infantil Prof. Fernando Figueira (5) · Massachusetts General Hospital (5) · Medical College of Wisconsin (5) · CHU de Quebec-Universite Laval (4) · Charite University, Berlin, Germany (4) · Hospital Universitari Vall d'Hebron Research Institute (4)
United States (121) · Egypt (28) · Turkey (Türkiye) (26) · China (21) · France (17) · Spain (15) · Canada (13) · Israel (13) · Brazil (11) · Germany (11) · Denmark (9) · United Kingdom (9) · Mexico (8) · Norway (8) · India (7)
Beverly Winikoff, Dr (4) · Emmanuel Bujold, MD, MSc (4) · Osvaldo Reyes, MD (4) · Ahmed Maged (3) · Ali Ovayolu, MD (3) · Fang He, M.D (3) · Ahmed Abbas, MD (2) · Ahmed Maged, MD (2) · Alisse Hauspurg, MD (2) · Ana C Plata, MSc (2) · Anna Palatnik, MD (2) · Anna Reid-Stanhewicz, PhD (2) · Anne Cathrine Staff, MD, PhD (2) · Boye L. Jensen, Professor (2)
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R21HD101127 (2), UL1TR001082 (2), 2009 (1), 2025 (1), K12AR086524 (1), K23HL095739 (1), K23HL153667 (1), K23HL159316 (1), K23HL159331 (1), K23NS107645 (1), R01HD112076 (1), R01MD017083 (1), R01MD017947 (1), R21HD110992 (1), R24HD113024 (1)