17 completed, 6 unknown, 4 not yet recruiting, 4 recruiting. 5 Phase 3, 4 Not applicable, 4 Phase 4, 2 Phase 2, 1 Phase 1.
Follow HELLP Syndrome: new trials by email Literature Review of HELLP Syndrome trials Research Report on HELLP Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor - Pregnancy-Associated Hypertension, Gestational Hypertension | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 174 | 2026-08-31 | 2026-08-24 |
| Vitamin D Supplementation Among Pregnant Women in Uganda for the Prevention of Hypertensive Disorders in Pregnancy, and Other Adverse Maternal and Foetal Outcomes oral 2.000 IU vitamin D3 (cholecalciferol) daily, in addition to routine ANC supplementations, Placebo - Preeclampsia, Eclampsia | Phase 4 | Not yet recruiting | St Mary's Hospital, Lacor | 1980 | 2026-06-01 | 2026-04-03 |
| PROTECT-Africa: Biomarker Validation for Preeclampsia Triage Hypertension, Pregnancy-Induced, HELLP Syndrome | Recruiting | Africa Clinical Research Network (ACRN) | 1106 | 2026-02-05 | 2026-09-09 | |
| Study of Prognostic Values of Platelet Indices and Inflammatory Markers in Patients With HELLP Syndrome. Group I: 30 patients with HELLP syndrome - HELLP Syndrome | Not yet recruiting | Sohag University | 60 | 2026-02-01 | 2026-01-30 | |
| Pilot Project Renal and Cardiovascular Tertiary Prevention in Preeclampsia Preeclampsia, HELLP Syndrome | Recruiting | University Hospital Schleswig-Holstein | 100 | 2024-11-01 | 2025-09-03 | |
| Preeclampsia Intervention Netherlands Metformin Hydrochloride, Placebo - Pre-Eclampsia Onset Less Than 37 Weeks, Pre-Eclampsia | Phase 3 | Not yet recruiting | Amsterdam UMC | 180 | 2024-08-01 | 2024-06-11 |
| Analysis of Biological Progression and Regression of HELLP Syndrome in Time HELLP Syndrome, Preeclampsia | Completed | CHU Mohammed VI Marrakech | 72 | 2023-07-01 | 2026-03-31 | |
| BH4 Blood Levels Variations in Pre Eclamptic Women BH4 blood level - Pre Eclampsia, Eclampsia, Antepartum | Completed | University Tunis El Manar | 300 | 2023-03-15 | 2023-12-07 | |
| Complement Regulation to Undo Systemic Harm in Preeclampsia Eculizumab - Preeclampsia, Severe Preeclampsia | Phase 2 | Terminated | Cedars-Sinai Medical Center | 2 | 2021-09-13 | 2023-11-29 |
| Pregnancy-Related Hypertension: Adherence to a New Type of Monitoring Home blood pressure monitoring - Gestational Hypertension, Preeclampsia | Not applicable | Completed | Prisma Health-Upstate | 202 | 2021-04-15 | 2023-05-18 |
| The Use of Eculizumab in HELLP Syndrome Eculizumab - HELLP Syndrome (HELLP), Third Trimester, Complement Abnormality | Phase 1 | Completed | Johns Hopkins University | 3 | 2021-02-23 | 2023-11-14 |
| Liver Disease in Pregnancy Pregnancy Disease, Cirrhosis, Liver | Unknown | King's College Hospital NHS Trust | 100 | 2019-05-09 | 2020-03-27 | |
| TTP and aHUS in Complicated Pregnancies ADAMTS 13, complement and angiogenic biomarkers - Thrombotic Thrombocytopenic Purpura, Atypical Hemolytic Uremic Syndrome | Unknown | University College, London | 150 | 2018-09-21 | 2018-09-25 | |
| General Anesthesia Versus Spinal Anesthesia in Patients of HELLP Syndrome Spinal Anesthesia, General Anesthesia - HELLP Syndrome | Not applicable | Completed | Assiut University | 60 | 2017-04-15 | 2018-05-18 |
| Evaluation of the Serum Markers sFLt1 and PlGF for the Prediction of the Complications of the Placental Vascular Pathologies in the 3rd Quarter of the Pregnancy. sampling of the serum marker sFlt1 and PlGF - Pre-Eclampsia, HELLP Syndrome | Completed | Centre Hospitalier Metropole Savoie | 233 | 2017-01-10 | 2022-06-14 | |
| Correlation of Survival in Puerperae by Electrical Impedance Tomography Sepsis, HELLP Syndrome, Respiratory Distress Syndrome Adult - Postpartum Period, Sepsis | Completed | Amazon University | 30 | 2017-01-01 | 2018-11-06 | |
| PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis Pre-Eclampsia, HELLP Syndrome | Recruiting | Maastricht University Medical Center | 226 | 2016-11-01 | 2024-12-05 | |
| A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Vitamin D3 - Gestational Hypertension, Toxemia | Phase 4 | Unknown | Stony Brook University | 412 | 2016-10-01 | 2017-10-05 |
| Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Acetaminophen, Ibuprofen - Pre-Eclampsia, HELLP Syndrome | Phase 4 | Completed | University of New Mexico | 100 | 2016-09-01 | 2023-07-27 |
| Women Specific Cardiac Recovery After Preeclampsia Venapunction - Pre-Eclampsia, Pregnancy | Unknown | Maastricht University Medical Center | 290 | 2016-06-01 | 2018-08-27 |
Showing 20 of 34. Sign in to see all of them.
Pre-Eclampsia (26) · Eclampsia (13) · Hypertension, Pregnancy-Induced (7) · Fetal Growth Retardation (5) · Hypertension (4) · Premature Birth (4) · Pregnancy Complications (3) · Abruptio Placentae (2) · Fetal Death (2) · Maternal Death (2) · Placental Insufficiency (2) · Thrombocytopenia (2) · Toxemia (2) · Acute Kidney Injury (1)
Female Urogenital Diseases and Pregnancy Complications (34) · Urogenital Diseases (34) · Pregnancy Complications (31) · Hypertension, Pregnancy-Induced (27) · Pathological Conditions, Signs and Symptoms (14) · Pathologic Processes (13) · Cardiovascular Diseases (8) · Vascular Diseases (8) · Obstetric Labor Complications (7) · Death (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Fetal Diseases (5) · Growth Disorders (5) · Hypertension (5) · Obstetric Labor, Premature (4)
Cholecalciferol (2) · Dexamethasone (2) · eculizumab (2) · Acetaminophen (1) · Anesthesia, General (1) · Anesthesia, Spinal (1) · Ascorbic Acid (1) · BaseLine dental cement (1) · Blood Pressure Monitoring, Ambulatory (1) · Blood Specimen Collection (1) · Calcium (1) · Calcium Channel Blockers (1) · Community Health Workers (1) · Dietary Supplements (1) · Ibuprofen (1)
Maastricht University Medical Center (3) · AYMAN ABDELKADER MOHAMED ABDELKADER (2) · Africa Clinical Research Network (ACRN) (1) · Amazon University (1) · Amsterdam UMC (1) · Assiut University (1) · Baylor College of Medicine (1) · CHU Mohammed VI Marrakech (1) · Cedars-Sinai Medical Center (1) · Centre Hospitalier Metropole Savoie (1) · Centre Hospitalier Universitaire de Nīmes (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Instituto Materno Infantil Prof. Fernando Figueira (1) · Johns Hopkins University (1) · King's College Hospital NHS Trust (1)
United States (8) · France (3) · Netherlands (3) · Brazil (2) · Germany (2) · United Kingdom (2) · Colombia (1) · Egypt (1) · India (1) · Morocco (1) · Switzerland (1) · Tunisia (1) · Zimbabwe (1)
Marc Spaanderman, MD, PhD (2) · Arthur J Vaught (1) · Baha Sibai (1) · Cynthia Morris (1) · David Soper, MD (1) · Diana J Garretto, MD (1) · Eleni Z Tsigas, BA (1) · Eve Mousty, MD (1) · Franck Perrotin, MD-PhD (1) · Gregor Seliger, Dr. med. (1) · Hayen Magherbi, pr (1) · Javier Fonseca, Dr (1) · Jesse Rattan, PhD, MPH, RN (1) · John Hauth (1)
PMID 10559107, PMID 111670, PMID 12133877, PMID 14566457, PMID 15128988, PMID 16360171, PMID 18055726, PMID 18928997, PMID 19255741, PMID 19325491, PMID 20936936, PMID 21835904, PMID 22681860, PMID 22748193, PMID 23697398, PMID 25556329, PMID 25693014, PMID 26397017, PMID 26903337, PMID 26947624, PMID 27033882, PMID 32979032, PMID 33813842, PMID 34724906, PMID 35241475, PMID 35559998, PMID 37734091, PMID 40413047
2023 (1), K12AR086524 (1), K12HD085845 (1), U01HD040565 (1)