401 completed, 190 unknown, 130 recruiting, 60 not yet recruiting. 278 Not applicable, 68 Phase 4, 61 Phase 3, 56 Phase 2, 27 Phase 1.
Follow Pre-Eclampsia: new trials by email Literature Review of Pre-Eclampsia trials Research Report on Pre-Eclampsia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention Clinician notification of elevated preeclampsia risk - Preeclampsia, Hypertensive Disorders of Pregnancy (HDP) | Not applicable | Not yet recruiting | Massachusetts General Hospital | 1000 | 2027-05-01 | 2026-05-29 |
| Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders Ravulizumab - Preeclampsia | Phase 2 | Recruiting | Mayo Clinic | 14 | 2027-04-01 | 2026-10-22 |
| Ophthalmic Artery Doppler in the Puerperium After Hypertensive Disorders of Pregnancy (OPHELIA-PP) Hypertensive Disorders of Pregnancy, Pre-eclampsia | Not yet recruiting | University of Roma La Sapienza | 366 | 2027-01-01 | 2026-09-25 | |
| Prevalence of Asymptomatic Bacteriuria Among Pregnant Women With Pre-eclampsia in Women Health Hospital Assiut University Pre-Eclampsia, Asymptomatic Bacteriuria | Not yet recruiting | Assiut University | 129 | 2026-11-01 | 2026-10-08 | |
| Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography Transthoracic Echocardiography - Preeclampsia | Suspended | Brigham and Women's Hospital | 80 | 2026-10-25 | 2026-01-20 | |
| Oxford Luteal Dysfunction and Placental Insufficiency Study No intervention planned - Pre-eclampsia | Recruiting | University of Oxford | 360 | 2026-10-23 | 2026-10-22 | |
| Vagal Stimulation Therapy and Preeclampsia Vagal stimulation physiotherapy with trigger point release, Positional Release Therapy - Gestational Hypertension, Preeclampsia | Not applicable | Recruiting | Fundación Internacional René Mey | 210 | 2026-10-15 | 2026-09-02 |
| A Feasibility Study to Evaluate the Safety of the KNP-1000 Apheresis System in Severe Preeclampsia KNP-1000 Apheresis System - Pre-Eclampsia, Severe | Not applicable | Not yet recruiting | Kaneka Medical America LLC | 13 | 2026-10-01 | 2026-08-28 |
| Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in Preeclampsia Dexamethasone, Ondansetron - Preeclampsia, Spinal Anesthesia-Induced Hypotension | Phase 4 | Not yet recruiting | Assiut University | 110 | 2026-10-01 | 2026-08-31 |
| Modelization of Early Endometrial-trophoblast Molecular Interaction Diagnostic hysteroscopy with endometrial biopsy - Infertility, Eclampsia Preeclampsia | Not applicable | Not yet recruiting | Centre Hospitalier Intercommunal Creteil | 500 | 2026-10-01 | 2026-09-17 |
| Use of Allied-health Professionals to Improve Treatment of Disease Research Pharmacist - Preeclampsia | Not applicable | Not yet recruiting | University of Iowa | 200 | 2026-10-01 | 2026-06-04 |
| Gestational Changes in Hemodynamics and Respiratory Mechanics in Association With Pre-Eclampsia Pre-eclampsia, Pregnancy | Not yet recruiting | Icahn School of Medicine at Mount Sinai | 100 | 2026-10-01 | 2026-09-28 | |
| Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities Care coordination, Electronic massage, support gift #1 - Preterm Birth Complication, Preterm Birth | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 1228 | 2026-10-01 | 2026-09-29 |
| Usability Evaluation of Gen AI-based Nutrition Chatbot for Pregnant Women a culturally tailored nutrition AI chatbot for pregnant women - Diabetes, Gestational, Pre-eclampsia | Not applicable | Not yet recruiting | Hong Kong Metropolitan University | 100 | 2026-10-01 | 2026-09-17 |
| Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia Furosemide and Potassium, Placebo - Severe Preeclampsia | Not applicable | Recruiting | Lady Reading Hospital, Pakistan | 434 | 2026-10-01 | 2026-10-06 |
| Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg - Hypertension in Pregnancy, Obstetrical Complications | Phase 3 | Not yet recruiting | The George Washington University Biostatistics Center | 4120 | 2026-09-30 | 2026-09-18 |
| MH-Rx Study (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure) Community Health Worker (CHW)/Social Worker (SW)-led non-medical health related needs (NMHRN) intervention + Clinician-Led Medication Therapy Management (MTM) with remote blood pressure monitoring, Active Comparator (Control group) - Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy | Not applicable | Recruiting | Texas Southern University | 158 | 2026-09-25 | 2026-10-14 |
| Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes Measurement of plasma nucleosome and placental growth factor (PLGF) levels - Preeclampsia, Premature Birth | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 900 | 2026-09-20 | 2026-09-25 | |
| Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period. Education, Blood Pressure Cuff, and Visual Cue Bracelet - Preeclampsia, Gestational Hypertension | Not applicable | Not yet recruiting | Memorial Hermann Health System | 40 | 2026-09-16 | 2026-09-08 |
| Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study None (this is an observational study with no intervention) - GDM, Preterm Preeclampsia | Recruiting | Medicines360 | 5500 | 2026-09-08 | 2026-09-30 |
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Hypertension, Pregnancy-Induced (146) · Hypertension (88) · Fetal Growth Retardation (70) · Pregnancy Complications (65) · Eclampsia (62) · Premature Birth (62) · Diabetes, Gestational (54) · Cardiovascular Diseases (31) · Toxemia (27) · HELLP Syndrome (26) · Obesity (22) · Proteinuria (15) · Stillbirth (15) · Abruptio Placentae (12)
Female Urogenital Diseases and Pregnancy Complications (881) · Urogenital Diseases (881) · Pregnancy Complications (816) · Hypertension, Pregnancy-Induced (735) · Vascular Diseases (216) · Cardiovascular Diseases (200) · Pathological Conditions, Signs and Symptoms (181) · Pathologic Processes (126) · Hypertension (118) · Nutritional and Metabolic Diseases (87) · Obstetric Labor Complications (86) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (82) · Fetal Diseases (70) · Growth Disorders (70) · Signs and Symptoms (64)
Aspirin (58) · Labetalol (19) · Magnesium Sulfate (18) · Blood Specimen Collection (15) · Nifedipine (13) · Phenylephrine (8) · Control Groups (7) · Furosemide (7) · Hematologic Tests (7) · Metformin (7) · Sodium Chloride (7) · Ascorbic Acid (6) · Cholecalciferol (6) · Methyldopa (6) · Misoprostol (6)
Assiut University (27) · Cairo University (18) · Assistance Publique - Hôpitaux de Paris (16) · Saint Thomas Hospital, Panama (11) · University of Oxford (11) · Ain Shams University (8) · Gynuity Health Projects (8) · Oslo University Hospital (8) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (7) · Massachusetts General Hospital (7) · Ohio State University (7) · Anna Stanhewicz, PhD (6) · Aswan University Hospital (6) · General Hospital of Ningxia Medical University (6) · Hadassah Medical Organization (6)
United States (216) · Egypt (72) · France (59) · Turkey (Türkiye) (49) · China (36) · Canada (31) · United Kingdom (29) · Israel (28) · Spain (25) · Brazil (20) · Denmark (20) · India (18) · Germany (17) · Italy (16) · Netherlands (16)
Osvaldo Reyes, MD (6) · Emmanuel Bujold, MD, MSc (5) · Ahmed Maged, MD (4) · Beverly Winikoff, Dr (4) · Xinli Ni, Dr. (4) · Ahmed Maged (3) · Ali Ovayolu, MD (3) · Alisse Hauspurg, MD (3) · Anna Palatnik, MD (3) · Fang He, M.D (3) · Osvaldo A Reyes, MD (3) · Rebecca R Kortum, PhD (3) · Tamara Garrido, PhD (3) · Ahmed Abbas, MD (2)
PMID 37815037, PMID 32748394, PMID 28657417, PMID 21440300, PMID 21596735, PMID 23741776, PMID 27640943, PMID 29588190, PMID 29939940, PMID 33481418, PMID 33779986, PMID 40886083, PMID 42305089, PMID 42418275, PMID 10137741, PMID 10578797, PMID 11057854, PMID 111670, PMID 11786196, PMID 11879422, PMID 11921380, PMID 12065368, PMID 12411285, PMID 12908998, PMID 14719181, PMID 15500369, PMID 15507947, PMID 15713717, PMID 15717289, PMID 15733401, PMID 15947178, PMID 16187156, PMID 16360171, PMID 16540963, PMID 16829207, PMID 17012443, PMID 17092344, PMID 17540809, PMID 17636190, PMID 17975258, PMID 18055726, PMID 18214429, PMID 18226126, PMID 18241822, PMID 18281199, PMID 18794220, PMID 18928997, PMID 19008055, PMID 19024419, PMID 19070896
2018 (2), R21HD101127 (2), U24HD036801 (2), UL1TR001082 (2), 2008 (1), 2009 (1), 2023 (1), 2025 (1), K12AR086524 (1), K23HL095739 (1), K23HL153667 (1), K23HL159316 (1), K23HL159331 (1), K23HL168356 (1), K23HL173684 (1)