5 recruiting, 4 completed, 1 enrolling by invitation, 1 not yet recruiting. 5 Not applicable, 3 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 2, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 3 | Recruiting 2, Completed 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Recruiting 1 |
Follow Posttraumatic Headache: new trials by email Literature Review of Posttraumatic Headache trials Research Report on Posttraumatic Headache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mindful RAVANS Study Cala-RAVANS (Model CR-2), Sham - mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 20 | 2026-11-01 | 2026-10-14 |
| Hypersensitivity to Adrenomedullin in Post-Traumatic Headache Adrenomedullin, Placebo - Posttraumatic Headache | Not applicable | Recruiting | Danish Headache Center | 21 | 2025-08-01 | 2025-07-30 |
| Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD Group A active comparator, Group B active comparator, Group C Experimental - Posttraumatic Headache, Posttraumatic Stress Disorder | Phase 2 | Recruiting | Northwestern University | 175 | 2025-07-02 | 2026-05-01 |
| Muscle Function and Tenderness Differences in Headache Patients Muscle function - Migraine, Tension Headache | Enrolling by invitation | Danish Headache Center | 90 | 2025-02-28 | 2025-03-10 | |
| Non-pharmacological Treatment of Patients at Risk of Developing Persistent Post-traumatic Headache: The PTHEENOT Study The intervention group - Posttraumatic Headache | Not applicable | Completed | Esbjerg Hospital - University Hospital of Southern Denmark | 104 | 2025-01-15 | 2026-10-07 |
| Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache Botox 200 UNT Injection - Posttraumatic Headache | Phase 3 | Recruiting | Danish Headache Center | 80 | 2025-01-10 | 2025-02-21 |
| Multisite Advancement of Research on Chronic Posttraumatic Headache Cognitive Behavioral Therapy for Posttraumatic Headache, Treatment as Usual, Telemedicine-based Cognitive Behavioral Therapy (TCBT) - Posttraumatic Headache | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 525 | 2023-08-24 | 2026-09-22 |
| Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI Erenumab 140 Mg/mL Subcutaneous Solution, Placebo - Posttraumatic Headache, Mild Traumatic Brain Injury | Phase 2 | Recruiting | Henry M. Jackson Foundation for the Advancement of Military Medicine | 404 | 2022-07-19 | 2024-02-22 |
| A Pilot Study of Intranasal Lidocaine in Acute Management of Pediatric Migraine Lidocaine 2% Injectable Solution, Normal Saline Flush, 0.9% Injectable Solution - Migraine in Children, Posttraumatic Headache | Phase 1 | Completed | University of British Columbia | 30 | 2019-07-03 | 2021-04-28 |
| Exercise in Patients With Post-Concussion Symptoms aerobic exercise program - Craniocerebral Trauma, Head Injury, Minor | Not applicable | Completed | St. Olavs Hospital | 30 | 2019-02-14 | 2022-03-15 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin prazosin hydrochloride, placebo - Posttraumatic Headache, Combat Disorders | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 89 | 2016-01-04 | 2026-03-30 |
Post-Traumatic Headache (11) · Brain Concussion (4) · Headache (2) · Post-Concussion Syndrome (2) · Stress Disorders, Post-Traumatic (2) · Chronic Pain (1) · Combat Disorders (1) · Craniocerebral Trauma (1) · Migraine Disorders (1) · Motor Activity (1) · Pain (1) · Tension-Type Headache (1)
Brain Diseases (11) · Central Nervous System Diseases (11) · Headache Disorders (11) · Headache Disorders, Secondary (11) · Nervous System Diseases (11) · Brain Injuries (4) · Brain Injuries, Traumatic (4) · Head Injuries, Closed (4) · Trauma, Nervous System (4) · Wounds and Injuries (4) · Wounds, Nonpenetrating (4) · Craniocerebral Trauma (3) · Mental Disorders (3) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3)
Adrenomedullin (1) · Cognitive Behavioral Therapy (1) · Lidocaine (1) · Prazosin (1) · Therapeutics (1) · erenumab (1) · salicylhydroxamic acid (1)
Danish Headache Center (3) · Esbjerg Hospital - University Hospital of Southern Denmark (1) · Henry M. Jackson Foundation for the Advancement of Military Medicine (1) · Northwestern University (1) · Spaulding Rehabilitation Hospital (1) · St. Olavs Hospital (1) · The University of Texas Health Science Center at San Antonio (1) · University of British Columbia (1) · VA Office of Research and Development (1)
Denmark (4) · United States (4) · Canada (1) · Norway (1)
Cynthia L Mayer, DO (1) · David L Brody, MD, PhD (1) · Donald D McGeary, PhD (1) · Garth Meckler, MD (1) · Steven Cohen, MD (1) · Toril Skandsen, md phd (1)
1IK2RX001136-01A2 (1)