9 completed. 9 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 9 |
| Phase 1 | 1 | Completed 1 |
Follow Post-Concussion Syndrome: new trials by email Literature Review of Post-Concussion Syndrome trials Research Report on Post-Concussion Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms Hyperbaric oxygen at 1.5 ATA, Sham treatment - Persistent Post-concussive Syndrome, Concussion Post Syndrome | Phase 2 | Completed | Essentia Health | 20 | 2022-06-28 | 2026-10-15 |
| Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache AMG 334 - Post-Traumatic Headache, Mild Traumatic Brain Injury | Phase 2 | Completed | Danish Headache Center | 100 | 2019-04-05 | 2020-02-10 |
| Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury Hyperbaric Oxygen, Minimal pressure air - Brain Injury, Chronic | Phase 2 | Completed | Lindell Weaver | 49 | 2017-09-06 | 2022-08-04 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin prazosin hydrochloride, placebo - Posttraumatic Headache, Combat Disorders | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 89 | 2016-01-04 | 2026-03-30 |
| Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury. Sildenafil - Traumatic Brain Injury, Post-concussive Syndrome | Phase 2 | Completed | Uniformed Services University of the Health Sciences | 59 | 2013-01-01 | 2016-01-01 |
| mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms Hyperbaric oxygen (HBO2) at 1.5 atms, Sham control 1.2 atms - Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 71 | 2012-09-11 | 2018-11-21 |
| Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) hyperbaric oxygen, sham hyperbaric air - Post-concussive Symptoms, Traumatic Brain Injury | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 79 | 2011-02-01 | 2014-09-05 |
| Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI) Hyperbaric Oxygen Therapy - Mild Traumatic Brain Injury, Post-Concussive Syndrome | Phase 2 | Completed | Virginia Commonwealth University | 60 | 2010-06-01 | 2013-08-27 |
| An Intervention Program to Reduce to the Risk of Persistent Symptoms After Concussion Treatment as usual, Cognitive-behavioural therapy - Mild Traumatic Brain Injury | Phase 2 | Completed | University of British Columbia | 28 | 2009-06-01 | 2018-11-06 |
Brain Concussion (5) · Brain Injuries, Traumatic (4) · Headache (2) · Post-Traumatic Headache (2) · Brain Injuries (1) · Brain Injury, Chronic (1) · Charcot-Marie-Tooth disease, Type 1F (1) · Combat Disorders (1) · Hypercapnia (1) · Stress Disorders, Post-Traumatic (1)
Craniocerebral Trauma (9) · Head Injuries, Closed (9) · Nervous System Diseases (9) · Trauma, Nervous System (9) · Wounds and Injuries (9) · Wounds, Nonpenetrating (9) · Brain Diseases (8) · Central Nervous System Diseases (8) · Brain Injuries (7) · Brain Concussion (4) · Brain Injuries, Traumatic (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Headache Disorders (2) · Headache Disorders, Secondary (2)
Hyperbaric Oxygenation (3) · Cognitive Behavioral Therapy (1) · Oxyhemoglobins (1) · Prazosin (1) · Sildenafil Citrate (1) · Therapeutics (1) · erenumab (1)
U.S. Army Medical Research and Development Command (2) · Danish Headache Center (1) · Essentia Health (1) · Lindell Weaver (1) · Uniformed Services University of the Health Sciences (1) · University of British Columbia (1) · VA Office of Research and Development (1) · Virginia Commonwealth University (1)
United States (7) · Canada (1) · Denmark (1)
Alice Rose (1) · Allen Thornton (1) · Brad Hallam (1) · Brett Hart, MD (1) · Cynthia L Mayer, DO (1) · David X Cifu, MD (1) · Eric Wassermann, MD (1) · Heather Underwood (1) · Justin O Alicea (1) · Kevin Whitfield (1) · Lindell K. Weaver, MD (1) · Lindell Weaver, MD (1) · Marc Basson, MD, PhD (1) · Marilyn Klug, PhD (1) · Maureen Whittal (1)
PMID 31394602, PMID 31394603, PMID 25401463, PMID 28768069, PMID 28768070, PMID 28768071, PMID 28768072, PMID 28768073, PMID 28768075, PMID 28771392, PMID 29734566, PMID 30098189, PMID 30099354, PMID 31394600, PMID 31394601, PMID 32493206, PMID 34873185
1IK2RX001136-01A2 (1), 2018 (1)