6 completed, 3 unknown, 1 recruiting. 3 Not applicable, 3 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 2 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Alkaptonuria: new trials by email Literature Review of Alkaptonuria trials Research Report on Alkaptonuria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acceptability/Tolerance of Protein Substitutes in Tablet Form for the Dietary Management of Rare Aminoacidopathies Zero minis (range of protein substitutes in tablet form) - Tyrosinemia, Type I, Tyrosinemia, Type II | Unknown | metaX Institut fuer Diatetik GmbH | 15 | 2024-04-01 | 2024-03-07 | |
| Evaluation of TYR Sphere in France Tyr sphere - Tyrosinemia, AKU | Not applicable | Completed | Vitaflo International, Ltd | 14 | 2021-12-01 | 2025-11-28 |
| Individualised Gait Modification Strategies in Alkaptonuria Patients Individualised gait modification intervention - Alkaptonuria | Not applicable | Unknown | Liverpool John Moores University | 30 | 2021-10-01 | 2021-02-26 |
| Evaluation of TYR Sphere TYR sphere - Tyrosinemias, Alkaptonuria | Not applicable | Completed | Vitaflo International, Ltd | 18 | 2019-10-01 | 2024-02-16 |
| Questionnaire Follow=up Study Sonia 2 Alkaptonuria, Homogentisic Acid | Completed | Liverpool University Hospitals NHS Foundation Trust | 24 | 2019-09-19 | 2025-03-26 | |
| Suitability of Nitisinone in Alkaptonuria 2 Nitisinone - Alkaptonuria | Phase 3 | Unknown | University of Liverpool | 140 | 2014-04-01 | 2018-05-31 |
| Dose Response Study of Nitisinone in Alkaptonuria Nitisinone - Alkaptonuria | Phase 2 | Completed | University of Liverpool | 40 | 2013-05-01 | 2014-06-11 |
| Nitisinone (NTBC) In Different Age Groups Of Patients With Alkaptonuria Nitisinone - Alkaptonuria | Phase 2 / Phase 3 | Completed | University of California, San Diego | 8 | 2011-01-01 | 2021-04-22 |
| Long-Term Study of Nitisinone to Treat Alkaptonuria Nitisinone (NTBC) - Alkaptonuria | Phase 2 | Completed | National Human Genome Research Institute (NHGRI) | 40 | 2005-01-01 | 2021-08-26 |
| Study of Alkaptonuria Alkaptonuria | Recruiting | National Human Genome Research Institute (NHGRI) | 300 | 2000-06-21 | 2026-10-16 |
Tyrosinemias (3) · Arthritis (2) · Ochronosis (2) · Corneal Injuries (1) · Ketosis (1) · Metabolic Diseases (1) · Metabolism, Inborn Errors (1) · Photophobia (1)
Amino Acid Metabolism, Inborn Errors (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Genetic Diseases, Inborn (10) · Nutritional and Metabolic Diseases (10) · Metabolic Diseases (9) · Metabolism, Inborn Errors (9) · Nervous System Diseases (4) · Brain Diseases (3) · Brain Diseases, Metabolic (3) · Brain Diseases, Metabolic, Inborn (3) · Central Nervous System Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Joint Diseases (2) · Musculoskeletal Diseases (2) · Pathologic Processes (2)
nitisinone (4)
National Human Genome Research Institute (NHGRI) (2) · University of Liverpool (2) · Vitaflo International, Ltd (2) · Liverpool John Moores University (1) · Liverpool University Hospitals NHS Foundation Trust (1) · University of California, San Diego (1) · metaX Institut fuer Diatetik GmbH (1)
United Kingdom (4) · United States (3) · France (1)
L Ranganath (2) · Anita MacDonald (1) · Anita MacDonald, Professor (1) · Gabor J Barton, MD, PhD (1) · Jean-Baptiste Arnoux (1) · Wendy J Introne, M.D. (1) · William L Nyhan, MD, PhD (1)
PMID 25475116, PMID 25665838, PMID 31296884, PMID 32822600, PMID 36270742