151 completed, 21 unknown, 10 recruiting, 10 terminated. 88 Not applicable, 29 Phase 3, 28 Phase 2, 21 Phase 1, 19 Phase 4.
Follow Osteopenia: new trials by email Literature Review of Osteopenia trials Research Report on Osteopenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes | Recruiting | Bettina Mittendorfer | 100 | 2027-01-01 | 2026-05-07 | |
| Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis Exercise training - Osteopenia, Osteoporosis | Not applicable | Withdrawn | University of Alabama at Birmingham | 2026-12-01 | 2026-07-01 | |
| Time-Restricted Eating and Exercise for Bone Health Time-restricted eating combined with resistance exercise (TRE+Ex), Habitual eating pattern combined with resistance exercise (HE+Ex) - Osteopenia | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 24 | 2026-11-01 | 2026-09-17 |
| Exercise and Fall Prevention for Fracture Reduction Guideline-based home exercise training - Osteopenia, Osteoporosis | Not applicable | Not yet recruiting | Wolfgang Kemmler, PhD | 72 | 2026-11-01 | 2026-10-29 |
| Calcium-Rich Food Versus Calcium Carbonate for Bone Health 500 mg calcium from milk-derived minerals, Calcium Carbonate 500 MG - Osteopenia, Osteoporosis | Not applicable | Not yet recruiting | Cornell University | 217 | 2026-09-01 | 2026-08-13 |
| High-Intensity Laser Therapy and Physiotherapy for Bone Health in Postmenopausal Women: A Randomized Trial High-Intensity Laser Therapy, Sham Laser, Standardised Physiotherapy Programme - Osteoporosis, Postmenopausal, Osteopenia | Not applicable | Not yet recruiting | Iuliu Hatieganu University of Medicine and Pharmacy | 40 | 2026-07-27 | 2026-07-29 |
| Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study Osteoporosis, Musculoskeletal Health | Recruiting | Kanuni Sultan Suleyman Training and Research Hospital | 200 | 2026-05-01 | 2026-06-30 | |
| Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia veverimer daily, veverimer every other day, Placebo - Osteopenia | Phase 1 | Recruiting | Tufts Medical Center | 60 | 2026-04-15 | 2026-10-26 |
| Food Trial Evaluating Fecal Abundance of SBD111 With Once-Daily Versus Twice-Daily Administration in Healthy Adults SBD111(current formulation), SBD111 (new formulation) - Osteopenia, Osteoporosis | Not applicable | Not yet recruiting | Solarea Bio, Inc | 80 | 2026-04-01 | 2026-04-20 |
| REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD) REMS - Osteogenesis Imperfecta, Osteoporosis | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 100 | 2025-12-04 | 2026-02-17 |
| Optimal Meals to Reduce Bone Resorption in Women With Osteopenia 200 ml dairy, 100 ml milk, 100 g banana - Osteopenia | Not applicable | Enrolling by invitation | University of Aarhus | 13 | 2025-12-01 | 2026-05-06 |
| Clinical Study to Estimate Bone Mineral Density With the POROUS Ultrasound Device Measurements with the POROUS R4C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine - Healthy, Osteopenia | Not applicable | Completed | POROUS GmbH | 350 | 2025-11-14 | 2026-09-18 |
| Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women Everolimus, Placebo, Resistance training - Healthy, Osteopenia | Phase 2 | Recruiting | Odense University Hospital | 148 | 2025-10-20 | 2026-04-06 |
| Vibration Applications After Total Knee Arthroplasty in Osteopenic Women Whole Body Vibration Therapy, Whole Body Vibration with Exercise, Conventional Physiotherapy - Osteopenia, Total Knee Arthroplasty | Not applicable | Completed | Istinye University | 48 | 2025-08-01 | 2026-06-30 |
| Evaluation of Bone Mineral Density Indications and Outcomes in Female Adolescents: Implications for Early Detection of Osteopenia/Osteoporosis and Gynecologic Practice Bone Density, Osteopenia | Completed | Bagcilar Training and Research Hospital | 74 | 2025-06-01 | 2025-09-15 | |
| Brief Title: The Role of Nutrition in the Rehabilitation of Patients With Eating Disorders After a Vascular Stroke. Dietary Supplement - Stroke, Hypoalbuminemia | Not applicable | Not yet recruiting | University of Ioannina | 100 | 2025-05-05 | 2025-05-08 |
| Effects of Resistance Exercise Compared to Whole-body Electromyostimulation in Young Female Dentists. Whole-Body Electromyostimulation, Resistance exercise - Osteopenia, Cardiometabolic Conditions | Not applicable | Completed | University of Erlangen-Nürnberg Medical School | 16 | 2025-03-15 | 2026-01-30 |
| Clinical Study to Predict the Risk of Bone Fractures With the POROUS Ultrasound Device Measurements with the POROUS R3C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine, DXA-based Vertebral Fracture Assessment (VFA) - Healthy, Osteopenia | Not applicable | Active not recruiting | POROUS GmbH | 1600 | 2025-03-03 | 2026-06-05 |
| Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease Resistance Exercise, Aerobic Training - Osteopenia, Bone Metabolism Disorders | Not applicable | Completed | Sinai University | 60 | 2025-01-01 | 2025-08-21 |
| Zoledronic Acid for the Prevention of TDF-sparing ART-induced Bone Mass Density Loss in Treatment-naive HIV Positive Individuals Zoledronic Acid 5 mg/Bag 100 ml Inj - HIV Infected Individuals, Osteopenia | Phase 4 | Recruiting | Hadassah Medical Organization | 110 | 2024-12-09 | 2025-09-18 |
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Bone Diseases, Metabolic (212) · Osteoporosis (121) · Motor Activity (15) · Sarcopenia (12) · Fractures, Bone (10) · Osteoporosis, Postmenopausal (10) · HIV Infections (9) · Vitamin D Deficiency (8) · Breast Neoplasms (6) · Bone Diseases (4) · Diabetes Mellitus (4) · Hip Fractures (4) · Hypertension (4) · Obesity (4) · Osteoporotic Fractures (4)
Metabolic Diseases (212) · Nutritional and Metabolic Diseases (212) · Musculoskeletal Diseases (211) · Bone Diseases (208) · Pathological Conditions, Signs and Symptoms (37) · Signs and Symptoms (22) · Urogenital Diseases (21) · Nervous System Diseases (20) · Behavior (17) · Endocrine System Diseases (17) · Neurologic Manifestations (17) · Wounds and Injuries (17) · Immune System Diseases (16) · Nutrition Disorders (16) · Pathologic Processes (16)
Vitamin D (14) · Calcium (11) · Alendronate (10) · Denosumab (10) · Exercise (10) · Zoledronic Acid (8) · Calcium Carbonate (7) · Cholecalciferol (7) · Resistance Training (7) · Risedronic Acid (7) · Dietary Supplements (4) · Soybean Proteins (4) · romosozumab (4) · Absorptiometry, Photon (3) · Ergocalciferols (3)
Amgen (13) · University of Erlangen-Nürnberg Medical School (5) · Duquesne University (4) · Massachusetts General Hospital (4) · University of Aarhus (4) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (3) · University of California, San Francisco (3) · Bagcilar Training and Research Hospital (2) · Creighton University (2) · Emory University (2) · Istituto Ortopedico Rizzoli (2) · Mayo Clinic (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Odense University Hospital (2) · POROUS GmbH (2)
United States (80) · Germany (13) · Canada (10) · Denmark (8) · France (8) · Australia (6) · China (6) · Turkey (Türkiye) (6) · Russia (5) · Greece (4) · Italy (4) · Poland (4) · Sweden (4) · Israel (3) · Netherlands (3)
Paula A Witt-Enderby, PhD (3) · Wolfgang Kemmler, PhD (3) · Anne Klibanski, MD (2) · Francesco Squadrito, MD (2) · Karen E Hansen, MD (2) · Karen Miller, MD (2) · Laura Bilek, PT, PhD (2) · Adam Wright, PhD (1) · Alan Richard Cohen (1) · Alessandra Galhardo (1) · Alicia E Ballok, PhD (1) · Allison Case, M.D. (1) · Amel M. Yousef, PhD (1) · Amy Sun, MD, PhD (1)
PMID 38979716, PMID 14504954, PMID 15159265, PMID 15746294, PMID 15883634, PMID 16076940, PMID 16087995, PMID 16096715, PMID 17190895, PMID 17313298, PMID 17577003, PMID 17911175, PMID 18039992, PMID 18256777, PMID 18767928, PMID 18796517, PMID 19246088, PMID 19906801, PMID 20063223, PMID 20142790, PMID 20168099, PMID 20168204, PMID 20193083, PMID 20357174, PMID 20484446, PMID 20827548, PMID 21037195, PMID 21412137, PMID 21492428, PMID 21806837, PMID 21824950, PMID 21912321, PMID 22084333, PMID 22113951, PMID 22152181, PMID 22215056, PMID 22220591, PMID 22235252, PMID 22289280, PMID 22350731, PMID 22443312, PMID 22848407, PMID 23150931, PMID 23312922, PMID 23446769, PMID 23873670, PMID 23940592, PMID 23979955, PMID 23983804, PMID 24909074
2008 (1), 2009 (1), K23AR048205 (1), K23HL148310 (1), N01AR002245 (1), P50AT000477 (1), R01AG025489 (1), R01AR043740 (1), R01AR046922 (1), R01AR048846 (1), R01AR048932 (1), R01AR059364 (1), R01DK084986 (1), R03AR055738 (1), R21AI058756 (1)