7 completed, 2 unknown, 1 terminated. 3 Phase 4, 2 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 3 | Completed 2, Unknown 1 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow oxycodone naloxone combination: new trials by email Literature Review of oxycodone naloxone combination trials Research Report on oxycodone naloxone combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targin® for Chronic Pain Management in Patients With Spinal Cord Injury Oxycodone Naloxone Combination - Chronic Pain | Phase 4 | Completed | University of British Columbia | 1 | 2019-09-05 | 2021-12-10 |
| GREAT - Good Response With Appropriate Treatment Oxycodone-Naloxone - Cancer Pain, Neoplasms | Completed | Mario Negri Institute for Pharmacological Research | 200 | 2014-11-01 | 2016-03-21 | |
| A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery Targinact, Oxycodone, Laparoscopic segmental colectomy - Postoperative Pain, Postoperative Nausea and Vomiting | Phase 3 | Completed | University of Edinburgh | 50 | 2014-10-01 | 2017-03-29 |
| Opioid Induced Bowel Dysfunction in Patients Undergoing Cesarean Section Caesarean section, Oxycodone, oxycodone-naloxone - Constipation, Pain, Postoperative | Phase 4 | Unknown | Kuopio University Hospital | 57 | 2012-10-01 | 2023-03-16 |
| A Non-interventional, Observational Study for Targinact® Treatment in Patients With Chronic Severe Pain Targinact® (oxycodone/naloxone) - Chronic Severe Pain | Completed | Mundipharma CVA | 68 | 2012-09-01 | 2015-04-08 | |
| A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment Targinact® (oxycodon/naloxon) - Chronic Severe Pain | Unknown | Mundipharma CVA | 1800 | 2012-09-01 | 2013-11-13 | |
| Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery oxycodone-naloxone, Oxycodone - Constipation | Phase 4 | Completed | Kuopio University Hospital | 180 | 2012-05-01 | 2015-10-12 |
| A Non-interventional, Observational Study for Targinact® Treatment in Patients With Severe Pain. Targinact® (oxycodone/naloxone) - Severe Pain | Completed | Mundipharma CVA | 1338 | 2011-04-01 | 2013-11-13 | |
| Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients Oxycodone Naloxone, Oxycodone PR Tablets - Constipation, Pain | Phase 3 | Terminated | Mundipharma SAS | 225 | 2010-02-01 | 2015-09-28 |
| A Study to Demonstrate the Analgesic Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Addition to Pregabalin Compared to Pregabalin Alone in Opioid-naïve Subjects Treated With Pregabalin Suffering From Moderate to Severe Pain Due to Diabetic Polyneuropathy Oxycodone Naloxone, Placebo tablets - Moderate to Severe Pain Due to Diabetic Polyneuropathy | Phase 2 | Completed | Mundipharma Research GmbH & Co KG | 98 | 2009-07-01 | 2012-08-17 |
Chronic Pain (4) · Opioid-Induced Constipation (4) · Pain (4) · Constipation (3) · Pain, Postoperative (2) · Agnosia (1) · Cancer Pain (1) · Neoplasms (1) · Postoperative Nausea and Vomiting (1) · Spinal Cord Injuries (1)
Mundipharma CVA (3) · Kuopio University Hospital (2) · Mario Negri Institute for Pharmacological Research (1) · Mundipharma Research GmbH & Co KG (1) · Mundipharma SAS (1) · University of British Columbia (1) · University of Edinburgh (1)
Belgium (3) · Finland (2) · Canada (1) · France (1) · Germany (1) · Italy (1) · United Kingdom (1)
Merja Kokki, MD, PhD (2) · Andrei Krassioukov, MD,PhD,FRCPC (1) · Hugh M Paterson, MD FRCS (1)
PMID 25757607, PMID 27762434, PMID 27921252, PMID 30073471
2008 (1), 2009 (1)