42 completed, 17 unknown, 9 recruiting, 5 not yet recruiting. 27 Not applicable, 9 Phase 4, 6 Phase 1, 6 Phase 3, 5 Phase 2.
Follow Ocular Surface Disease: new trials by email Literature Review of Ocular Surface Disease trials Research Report on Ocular Surface Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ocular Surface Disease in Glaucoma Patients on Long-Term Therapy Glaucoma, Ocular Surface Disease | Not yet recruiting | Assiut University | 55 | 2026-09-26 | 2026-09-28 | |
| Evaluation of Lacrifill Lacrifill, Saline - Dry Eye, Ocular Surface Disease | Phase 4 | Recruiting | Eye Research Associates, LLC | 40 | 2026-09-02 | 2026-09-25 |
| Effect of Acoltremon Ophthalmic Solution 0.003% on Signs and Symptoms of Ocular Surface Disease in Stage I Neurotrophic Keratopathy Patients With Tear Deficiency Patients will receive topical Acoltremon 0.003% ophthalmic solution BID in both eyes over an 8 week period., Alternative would be patient exiting the trial and starting on tears or other standard of care. - Ocular Surface Disease, Neurotrophic Keratopathy Stage 1 | Phase 4 | Recruiting | University of South Florida | 50 | 2026-04-06 | 2026-08-12 |
| The Efficacy of Intradermal Acupuncture for Ocular Surface Diseases After Intractable Facial Paralysis Intradermal acupuncture treatment, Sham intradermal acupuncture - Facial Paralysis, Peripheral, Bell's Palsy | Not applicable | Recruiting | The First Affiliated Hospital of Zhejiang Chinese Medical University | 78 | 2026-04-01 | 2026-04-17 |
| This is a Single Center, Open-label Prospective Study to Evaluate the Effect of Xiidra® (Lifitegrast Ophthalmic Solution 5.0%) on Tear Film Biomarkers in Dry Eye (Xiidra®) Lifitegrast Ophthalmic Solution 5.0% - Ocular Surface Disease, Dry Eye Syndrome (DES) | Phase 4 | Not yet recruiting | Pittsburgh Research Institute | 36 | 2026-03-01 | 2026-03-24 |
| Study to Evaluating PRO-240 Ophthalmic Solution Compared to Optive® PRO-240, Optive® - Dry Eye Disease, Dry Eye Sensation | Phase 1 | Not yet recruiting | Laboratorios Sophia S.A de C.V. | 32 | 2026-01-30 | 2025-03-19 |
| Wide Field OCTA in Ocular Diseases Age - Related Macular Degeneration (AMD), Diabetic Macular Edema | Not yet recruiting | IRCCS San Raffaele | 200 | 2026-01-01 | 2025-12-30 | |
| Establishment of a Multimodal Standard Database for Inflammation-related Ophthalmopathy Ocular Surface Disease, Inflammatory Disease | Recruiting | Dan Chen | 3000 | 2025-11-26 | 2026-06-05 | |
| Efficacy and Safety of Oral Probiotics on Ocular Symptoms and Gut Microbiome of Children with Vernal Keratoconjunctivitis Probiotic, Placebo Drug - Probiotic, Ocular Surface Disease | Phase 1 | Not yet recruiting | Mohsen Pourazizi | 32 | 2025-02-01 | 2025-01-27 |
| Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery Low-Level Light Therapy, Sham (No Treatment) - Dry Eye, Meibomian Gland Dysfunction (Disorder) | Not applicable | Completed | Grigore T. Popa University of Medicine and Pharmacy | 98 | 2025-01-08 | 2026-01-02 |
| Twice-Daily Systane Complete Versus Four-Times-Daily Thealoz Duo for Dry Eye Disease Systane Complete, Thealoz Duo - Dry Eye Syndrome (DES), Ocular Surface Disease | Not applicable | Completed | Instituto Internacional de Medicina y Terapia (IIMET) | 120 | 2025-01-06 | 2026-07-24 |
| Eyelid Closure in Keratometry Eyelid closure for 3 minutes - Dry Eye, Ocular Surface Disease | Not applicable | Recruiting | Vienna Institute for Research in Ocular Surgery | 29 | 2024-11-07 | 2025-12-22 |
| The Effect of Eye Care With Artificial Tears and Normal Saline on Ocular Surface Disease in Mechanically Ventilated Pediatric Patients Eye Care with Artificial Tears, Eye Care with Normal Saline - Ocular Surface Disease | Not applicable | Completed | Marmara University | 42 | 2024-11-01 | 2025-06-03 |
| Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024 Group 1 drug, Group 2: Drug and placebo, Group 3: Drug and palcebo - Ocular Surface Symptom, Ocular Surface Disease | Phase 1 | Unknown | Mohsen Pourazizi | 150 | 2024-10-30 | 2024-10-03 |
| Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Femto-Lasik Surgery Low-Level Light Therapy, Sham (No Treatment) - Dry Eye, Meibomian Gland Dysfunction (Disorder) | Not applicable | Completed | Grigore T. Popa University of Medicine and Pharmacy | 61 | 2024-08-10 | 2025-09-25 |
| Clinical Application Research of Scleral Lenses in Ocular Surface Diseases scleral lenses - Ocular Surface Disease | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 20 | 2024-08-08 | 2024-08-15 | |
| Investigator-initiated Clinical Trial to Observe Conjunctival Goblet Cell Using an Anterior Segment Imaging Device Imaging of conjunctival goblet cell - Ocular Surface Disease | Not applicable | Unknown | Seoul National University Hospital | 148 | 2024-06-12 | 2024-06-20 |
| Clinical Study to Evaluate the Safety and Tolerability of PRO-229 Ophthalmic Solution Compared to Lagricel® Ofteno PF PRO-229, Lagricel® Ofteno PF - Dry Eye Disease, Ocular Surface Disease | Phase 1 | Completed | Laboratorios Sophia S.A de C.V. | 36 | 2024-05-16 | 2025-03-04 |
| The Pattern of Dry Eye Disease After Cataract Surgery Artificial tears (sodium hyaluronate 0.2%) - Dry Eye Disease, Cataract | Recruiting | Lithuanian University of Health Sciences | 100 | 2024-03-01 | 2024-03-07 | |
| A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocular Surface Dexamethasone, tobramycin, netilimicin - Ocular Surface Disease, Dry Eye Syndromes | Phase 4 | Unknown | Kasr El Aini Hospital | 60 | 2024-01-10 | 2024-05-08 |
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Dry Eye Syndromes (32) · Glaucoma (9) · Meibomian Gland Dysfunction (6) · Glaucoma, Open-Angle (3) · Sjogren's Syndrome (3) · Stevens-Johnson Syndrome (3) · Eye Diseases (2) · Eye Pain (2) · Keratoconjunctivitis Sicca (2) · Keratoconus (2) · Ocular Hypertension (2) · Retinal Diseases (2) · Astigmatism (1) · Autistic Disorder (1) · Bell Palsy (1)
Eye Diseases (54) · Lacrimal Apparatus Diseases (32) · Ocular Hypertension (10) · Immune System Diseases (8) · Eyelid Diseases (7) · Mouth Diseases (7) · Stomatognathic Diseases (7) · Skin and Connective Tissue Diseases (6) · Conjunctival Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Arthritis (4) · Conjunctivitis (4) · Corneal Diseases (4) · Hypersensitivity (4) · Joint Diseases (4)
Latanoprost (3) · Hyaluronic Acid (2) · Low-Level Light Therapy (2) · Punctal Plugs (2) · Timolol (2) · Travoprost (2) · Wettability (2) · lifitegrast (2) · tafluprost (2) · Bimatoprost (1) · Brimonidine Tartrate (1) · CD5L protein, human (1) · Calcium Dobesilate (1) · Contact Lenses, Hydrophilic (1) · Cyclosporins (1)
Boston Sight (3) · Aristotle University Of Thessaloniki (2) · Grigore T. Popa University of Medicine and Pharmacy (2) · Laboratorios Sophia S.A de C.V. (2) · Mahidol University (2) · Marmara University (2) · Mohsen Pourazizi (2) · National Taiwan University Hospital (2) · Santen SAS (2) · Seoul National University Hospital (2) · Singapore National Eye Centre (2) · Akdeniz University (1) · Assiut University (1) · Benha University (1) · Campus Bio-Medico University (1)
United States (20) · China (7) · Turkey (Türkiye) (5) · Taiwan (4) · Austria (3) · France (3) · Italy (3) · Thailand (3) · Greece (2) · Mexico (2) · Romania (2) · South Korea (2) · Brazil (1) · Canada (1) · Croatia (1)
Daniel Brocks, MD (2) · Ahmad A Aref, MD (1) · Anastasios G Konstas, MD, PhD (1) · Andreas Katsanos, MD, PhD (1) · AssocProf Pinnita Tanthuvanit, MD (1) · Chang Ho Yoon, MD PhD (1) · Cynthia Matossian, MD (1) · Dalia Denisse Ng-Aleman, MD (1) · Daniel C Brocks, MD (1) · Donald T Tan, FRCS (1) · Donald TH Tan, FRCS(G) (1) · Douglas Jin, MD (1) · Douglas Lyall, FRCOphth (1)
PMID 15161841, PMID 15287367, PMID 23215770, PMID 23335308, PMID 27913991, PMID 28797892, PMID 29849435, PMID 31611797, PMID 31823206, PMID 32564453, PMID 32789800, PMID 33504920, PMID 34406502, PMID 36114405, PMID 36972140, PMID 40151655, PMID 40849606, PMID 42183401, PMID 42549110
2016 (1)