38 completed, 13 unknown, 5 recruiting, 3 not yet recruiting. 17 Not applicable, 8 Phase 4, 7 Phase 2, 1 Phase 1.
Follow Low Tension Glaucoma: new trials by email Literature Review of Low Tension Glaucoma trials Research Report on Low Tension Glaucoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Insulin for Glaucoma (TING2) EYED-002 Low Dose (721 U/mL topical insulin), EYED-002 High Dose (1442 U/mL topical insulin), EYED-002 (highest tolerated dose, 12-month) - Open Angle Glaucoma, Primary Open Angle Glaucoma | Phase 1 / Phase 2 | Enrolling by invitation | Stanford University | 90 | 2026-09-10 | 2026-10-13 |
| Single-site Pilot Study Evaluating the Effect of QLS-111 Ophthalmic Solution on Posterior Perfusion and Vessel Dilation QLS-111 Ophthalmic Solution (0.015%), QLS-111 Ophthalmic Solution (0.075%) - Non-proliferative Diabetic Retinopathy (NPDR), Open-angle Glaucoma (OAG) | Phase 2 | Active not recruiting | Qlaris Bio, Inc. | 14 | 2026-02-20 | 2026-09-14 |
| DSLT in Normal Tension Glaucoma (NTG) Asian Eyes Direct Selective Laser Trabeculoplasty (DSLT) - Normal Tension Glaucoma (NTG), Glaucoma | Not applicable | Not yet recruiting | Ngoc Nguyen Inc. | 40 | 2026-01-01 | 2025-12-24 |
| Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center Study Neuro-Ophthalmology, Optic Neuropathies | Not yet recruiting | Barboni | 70 | 2025-10-01 | 2025-07-20 | |
| Obstructive Sleep Apnea as a Risk Factor for Normal Tension Glaucoma and a Crucial Step in Preventing Blindness Clinical observation, diagnostic testing - Normal Tension Glaucoma, Obstructive Sleep Apnea | Not yet recruiting | Northwell Health | 100 | 2025-09-02 | 2025-06-10 | |
| Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG) QLS-111 ophthalmic solution (0.015%), Timolol Maleate PF 0.5% Ophthalmic Solution (Timolol) - Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral | Phase 2 | Completed | Qlaris Bio, Inc. | 37 | 2025-08-13 | 2026-04-03 |
| Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma Transcorneal electrical stimulation (TES) with the OkuStim 2 System - Glaucoma, Primary Open Angle Glaucoma | Not applicable | Recruiting | Okuvision GmbH | 50 | 2025-04-02 | 2026-03-12 |
| 24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring miLens system - Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder) | Completed | Smartlens, Inc. | 86 | 2025-02-19 | 2026-04-01 | |
| Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost Netarsudil, Brimonidine - Normal Tension Glaucoma | Phase 4 | Completed | Westlake Eye Specialists | 100 | 2024-06-13 | 2025-10-22 |
| R&D of Non-invasive Innovative Intracranial Waves Monitoring System for Diagnostics and Treatment Monitoring of Patients with Normal Tension Glaucoma Monitoring of cerebral hemodynamics - Normal Tension Glaucoma | Unknown | Lithuanian University of Health Sciences | 156 | 2024-04-22 | 2024-10-09 | |
| Direct Selective Laser Trabeculoplasty in Ethnic Chinese Population External Automatic Glaucoma Laser, Direct Selective Laser Trabeculoplasty - Primary Open Angle Glaucoma, Ocular Hypertension | Not applicable | Active not recruiting | BelkinVision | 40 | 2024-03-11 | 2026-08-17 |
| EVALUATION of CATS TONOMETER PRISM in LASIK SUBJECTS This is observational IOP measurement - Glaucoma, Ocular Hypertension | Completed | Intuor Technologies, Inc. | 198 | 2024-02-12 | 2024-11-05 | |
| Deep Sclerectomy Versus Trabeculectomy in Normal Tension Glaucoma Trabeculectomy, Deep Sclerectomy - Normal Tension Glaucoma | Not applicable | Recruiting | Helsinki University Central Hospital | 80 | 2022-05-31 | 2024-03-15 |
| Trabecular Microbypass IStent in Patients with Glaucoma first generation iStent (Glaukos, San Clemente, CA, USA) insertion, phacoemulsification - Primary Open Angle Glaucoma (POAG), Istent Inject W | Not applicable | Completed | Yu-Ting Tsao | 71 | 2022-05-16 | 2024-10-08 |
| Study in Prostaglandin Associated Peri-orbitopathy Switching From Prostaglandin Monotherapy to Omidenepag Isopropyl Eybelis ophthalmic solution 0.002% - Normal Tension Glaucoma, Primary Open-angle Glaucoma | Phase 4 | Unknown | Santen Pharmaceutical Asia Pte. Ltd. | 150 | 2022-02-15 | 2022-03-15 |
| Water Drinking Test Study and Disc Hemorrhages in Normal Tension Glaucoma water drinking test - Normal Tension Glaucoma | Not applicable | Unknown | University of Manitoba | 20 | 2021-10-01 | 2021-10-12 |
| A Study to Evaluate Safety and Tolerability of QLS-101 in NTG QLS-101, Timolol maleate PF 0.5% ophthalmic solution - Normal Tension Glaucoma (NTG) | Phase 2 | Completed | Qlaris Bio, Inc. | 30 | 2021-09-15 | 2025-01-20 |
| Intraocular Pressure Reduction Efficacy of Rhopressa and Lumigan in Normal Tension Glaucoma Netarsudil Ophthalmic, Bimatoprost Ophthalmic - Normal Tension Glaucoma | Phase 4 | Unknown | Salus University | 115 | 2021-08-01 | 2021-08-06 |
| The Water Drinking Test in Glaucoma Study Modified Diurnal Tension Curve - Glaucoma | Completed | Imperial College London | 46 | 2021-03-17 | 2024-09-19 | |
| Endoscopic Cyclophotocoagulation in Normal Tension Glaucoma Phaco, Phaco+ECP - Normal Tension Glaucoma, Cataract | Not applicable | Recruiting | Helsinki University Central Hospital | 100 | 2020-12-08 | 2020-12-22 |
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Glaucoma, Open-Angle (30) · Glaucoma (27) · Ocular Hypertension (10) · Glaucoma, Angle-Closure (3) · Cataract (2) · Exfoliation Syndrome (2) · Sleep Apnea, Obstructive (2) · Astigmatism (1) · Corneal Diseases (1) · Diabetic Retinopathy (1) · Dilatation, Pathologic (1) · Keratoconus (1) · Neoplasms (1) · Optic Atrophy, Hereditary, Leber (1)
Eye Diseases (65) · Optic Nerve Diseases (64) · Ocular Hypertension (55) · Glaucoma (38) · Nervous System Diseases (3) · Apnea (2) · Cardiovascular Diseases (2) · Dyssomnias (2) · Iris Diseases (2) · Lens Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Respiration Disorders (2) · Respiratory Tract Diseases (2) · Sleep Apnea Syndromes (2) · Sleep Disorders, Intrinsic (2)
Brimonidine Tartrate (6) · Ophthalmic Solutions (4) · Timolol (4) · Tomography, Optical Coherence (3) · Brimonidine Tartrate, Timolol Maleate Drug Combination (2) · Travoprost (2) · Bimatoprost (1) · Blood Pressure (1) · Corneal Topography (1) · Exercise (1) · Insulin (1) · Latanoprost (1) · Mutagenesis, Insertional (1) · Phacoemulsification (1) · Tomography (1)
Universitaire Ziekenhuizen KU Leuven (7) · Qlaris Bio, Inc. (3) · Technische Universität Dresden (3) · Wills Eye (3) · Augenabteilung Allgemeines Krankenhaus Linz (2) · Helsinki University Central Hospital (2) · Medical University of Vienna (2) · The Catholic University of Korea (2) · University of North Carolina, Chapel Hill (2) · Alcon Research (1) · Allergan (1) · Barboni (1) · BelkinVision (1) · Chicago Center for Vision Research (1) · Chinese University of Hong Kong (1)
United States (19) · South Korea (8) · Belgium (7) · Austria (4) · Germany (3) · China (2) · Finland (2) · Japan (2) · Poland (2) · United Kingdom (2) · Canada (1) · France (1) · Israel (1) · Lithuania (1) · Singapore (1)
Ingeborg Stalmans, MD, PhD (4) · B. Wirostko, M.D. (1) · Barbara M Wirostko, MD (1) · Chan Kee Park, M.D., PhD. (1) · Dan Gaa'ton, MD (1) · Daniel Lee, MD (1) · Danyel Carr, MS (1) · Dennis Lam, MD, FRCOphth (1) · Dexter Leung, MBChB, FRCS (1) · Dorit Raz Prag (1) · Elisabeth Renard, Doctor, MD (1) · Francesca Cordeiro (1) · Francisco W Rodrigues, Professor (1) · Frederick Mikelberg, MD (1)
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K23EY026098 (1)