34 completed, 4 terminated, 3 unknown, 1 not yet recruiting. 22 Phase 4, 9 Phase 3, 7 Not applicable, 5 Phase 2, 1 Phase 1.
Follow dorzolamide-timolol combination: new trials by email Literature Review of dorzolamide-timolol combination trials Research Report on dorzolamide-timolol combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of DNN.31.19.026 for Ocular Hypertension or Primary Open-Angle Glaucoma Product DNN.31.19.026, COSOPT® - Ocular Hypertension, Primary Open Angle Glaucoma | Phase 3 | Not yet recruiting | Ache Laboratorios Farmaceuticos S.A. | 336 | 2026-06-01 | 2026-06-01 |
| Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost Simbrinza 0.2%-1% Ophthalmic Suspension, Rocklatan 0.02%-0.005% Ophthalmic Solution, Cosopt PF 2%-0.5% Ophthalmic Solution - Open Angle Glaucoma | Phase 4 | Recruiting | Prairie Eye Center | 70 | 2025-05-14 | 2025-05-15 |
| How Much Does Reduced Dosing of Latanoprost and Dorzolamide-timolol Affect Pressure? dorzolamide/timolol - Glaucoma, Open-Angle, Glaucoma; Drugs | Phase 4 | Terminated | CT Glaucoma Associates | 36 | 2024-04-22 | 2024-08-23 |
| Dorzolamide+Timolol Multidose Preservative-free vs Dorzolamida+Timolol BAK Preserved Efficacy and Safety Dorzolamide / Timolol Ophthalmic Solution, dorzolamide/timolol - Glaucoma, Open-Angle, Ocular Hypertension | Phase 4 | Completed | Laboratorios Poen | 84 | 2023-03-07 | 2024-11-06 |
| Comparative Study of the Efficacy of Either Krytantek Ofteno PF® or Eliptic Ofteno PF® Plus Gaap Ofteno PF® for POAG or Ocular Hypertension. Dorzolamide-timolol-brimonidine and latanoprost, Dorzolamide-timolol and latanoprost - Glaucoma, Open-Angle, Ocular Hypertension | Phase 4 | Terminated | Laboratorios Sophia S.A de C.V. | 28 | 2021-10-19 | 2026-05-07 |
| Effectiveness and Safety of Timolol and Dorzolamide Loaded Contact Lenses timolol maleate and dorzolamide hydrochloride - Glaucoma | Phase 1 | Completed | University of Florida | 2 | 2018-01-18 | 2021-12-02 |
| Comparative Study of Dorzotimol Eye Drops, 20 mg/mL + 5 mg/mL Versus Cosopt® Eye Drops, 20 mg/mL + 5 mg/mL Dorzotimol eye drops, 20 mg/mL + 5 mg/mL, Cosopt eye drops, 20 mg/mL + 5 mg/mL - Primary Open Angle Glaucoma of Both Eyes | Phase 3 | Completed | Jadran Galenski laboratorij d.d. | 110 | 2017-04-10 | 2023-08-02 |
| Dorzolamide-timolol in Combination With Anti-vascular Endothelial Growth Factor Injections for Wet Age-related Macular Degeneration Dorzolamide-timolol, Artificial tears - Neovascular Age-related Macular Degeneration, Wet Macular Degeneration | Phase 2 / Phase 3 | Completed | Wills Eye | 52 | 2017-02-08 | 2020-06-19 |
| 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy tafluprost, tafluprost and dorzolamide/timolol - Glaucoma, Ocular Surface Disease | Phase 4 | Completed | Aristotle University Of Thessaloniki | 43 | 2015-03-01 | 2020-12-17 |
| Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME. Dorzolamide-timolol - Wet Macular Degeneration, Age-related Macular Degeneration | Phase 2 | Completed | Wills Eye | 14 | 2015-02-01 | 2019-12-03 |
| Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution Brinzolamide 1%/Timolol maleate 0.5% fixed combination ophthalmic suspension, Dorzolamide hydrochloride 1%/Timolol maleate 0.5% ophthalmic solution, Subject's habitual PGA monotherapy - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon, a Novartis Company | 218 | 2014-12-01 | 2016-12-08 |
| Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Timolol & Dorzolamide - Open Angle Glaucoma | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 30 | 2014-01-01 | 2024-07-16 |
| Patient Preference Comparison of AZARGA Versus COSOPT Brinzolamide 1.0% + Timolol 0.5% ophthalmic suspension, Dorzolamide 2.0% + Timolol 0.5% ophthalmic solution - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 112 | 2011-09-01 | 2014-02-10 |
| The Effect of Glaucoma Drops on of the Duration of a Pure Intraocular Gas Bubble Timolol-dorzolamide (Glaucoma drops), standard post-operative topical drops - Scleral Buckling | Not applicable | Completed | Jason Hsu, MD | 21 | 2011-06-01 | 2018-05-30 |
| Intraocular Pressure and Ocular Perfusion Pressure of Cosopt in Normal Tension Glaucoma dorzolamide/timolol, latanoprost - Normal Tension Glaucoma | Not applicable | Completed | The Catholic University of Korea | 44 | 2011-03-01 | 2015-01-08 |
| Safety Study of Aqueous Suppression After Ahmed Glaucoma Valve (AGV) Implantation Timolol-trusopt, placebo - Hypertensive Phase | Phase 2 | Unknown | Zahra Rabbani Khah | 94 | 2011-01-01 | 2013-03-20 |
| Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Glaucoma Brinzolamide/Timolol Maleate Fixed Combination (AZARGA), Dorzolamide/timolol Maleate Fixed Combination (COSOPT) - Glaucoma | Phase 4 | Completed | Alcon Research | 120 | 2010-09-01 | 2016-11-21 |
| Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Prospective Data (Cosopt®, prostaglandin) - Glaucoma | Completed | Indiana University | 56 | 2010-06-01 | 2014-01-22 | |
| Comparison of the Efficacy of AZARGA® Versus COSOPT® in Patients With Open-Angled Glaucoma or Ocular Hypertension Azarga (brinzolamide 1% / timolol 0.5%), Cosopt (dorzolamide 2% / timolol 0.5%) - Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 70 | 2010-04-01 | 2015-07-29 |
| Effect of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy Dorzolamide 2%-timolol 0.5% topical eyedrops - Macular Hole, Retinal Detachment | Not applicable | Completed | Mid Atlantic Retina | 21 | 2010-02-01 | 2019-09-04 |
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Ocular Hypertension (23) · Glaucoma (22) · Glaucoma, Open-Angle (20) · Macular Degeneration (2) · Wet Macular Degeneration (2) · Disease Progression (1) · Exfoliation Syndrome (1) · Eye Diseases (1) · Low Tension Glaucoma (1) · Macular Edema (1) · Retinal Detachment (1) · Retinal Perforations (1) · Retinal Vein Occlusion (1)
Alcon Research (9) · Merck Sharp & Dohme LLC (4) · Allergan (2) · Aristotle University Of Thessaloniki (2) · Laboratorios Sophia S.A de C.V. (2) · Wills Eye (2) · Ache Laboratorios Farmaceuticos S.A. (1) · Advanced Glaucoma Specialists (1) · Alcon, a Novartis Company (1) · Bp Consulting, Inc (1) · CT Glaucoma Associates (1) · Indiana University (1) · Jadran Galenski laboratorij d.d. (1) · Jason Hsu, MD (1) · Laboratorios Poen (1)
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PMID 19476406, PMID 12614754, PMID 14509472, PMID 16303952, PMID 17102003, PMID 19365194, PMID 20668720, PMID 20874498, PMID 21735753, PMID 21878847, PMID 23377586, PMID 26756747, PMID 26914218, PMID 2788589, PMID 27913991, PMID 29864044, PMID 32239190, PMID 40873654, PMID 8562550
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