488 completed, 140 terminated, 138 recruiting, 83 active not recruiting. 968 Phase 1, 289 Phase 2.
Follow Nervous System Neoplasms: new trials by email Literature Review of Nervous System Neoplasms trials Research Report on Nervous System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2027-01-01 | 2026-10-30 |
| Efficacy and Safety of HN2301 in Patients With Generalized Myasthenia Gravis (MG) HN2301 injection - Generalized Myasthenia Gravis | Phase 1 | Not yet recruiting | Shenzhen MagicRNA Biotechnology Co., Ltd | 6 | 2026-12-31 | 2026-08-12 |
| Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-10-30 |
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG) | Phase 1 / Phase 2 | Not yet recruiting | NanOlogy, LLC | 20 | 2026-12-01 | 2026-08-18 |
| Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures Panitumumab-IRDye800, Pinpoint-IR9000 endoscopic/handheld device, Explorer Air camera - Brain Tumor | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-12-01 | 2026-09-29 |
| OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma CT-179 - Recurrent Glioblastoma, Newly Diagnosed MGMT Unmethylated Glioblastoma | Phase 1 | Not yet recruiting | Olivia Newton-John Cancer Research Institute | 54 | 2026-12-01 | 2026-10-28 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-11-30 | 2026-10-30 |
| A Study of SRN-101 Administered Prior to Surgical Resection in Adults With Recurrent High-Grade Glioma. SRN-101, Blood Specimen Collection, Surgical Resection - Recurrent High-Grade Gliomas, Brain Neoplasm | Phase 1 | Not yet recruiting | Nicholas Butowski | 6 | 2026-11-15 | 2026-10-27 |
| IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, CD70 IHC assay - Brain Metastases | Phase 1 | Recruiting | University of Florida | 12 | 2026-10-13 | 2026-10-16 |
| Study of Zanzalintinib in Children and Adolescents With Relapsed or Refractory Solid Tumors Zanzalintinib - Cancer, Pediatric Cancer | Phase 1 | Not yet recruiting | Exelixis | 18 | 2026-09-30 | 2026-08-19 |
| An Open-label, Dose-escalation Phase Ib Study of EA5 Injection in Adults With Anti-AChR Antibody-Positive Generalized Myasthenia Gravis EA5 - Generalized Myasthenia Gravis (gMG) | Phase 1 | Not yet recruiting | Shanghai Lanyi Therapeutics Co., Ltd. | 18 | 2026-09-15 | 2026-09-14 |
| A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors NEO100 - Pediatric Tumor of CNS, Pediatric Tumor of Brain | Phase 1 | Recruiting | Neonc Technologies, Inc. | 12 | 2026-09-08 | 2026-09-15 |
| A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal Disease SX-682, Proton Craniospinal Irradiation (pCSI) - Leptomeningeal Disease (LMD) | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 40 | 2026-09-04 | 2026-09-11 |
| A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab Computed Tomography, Copper Cu 64-DOTA-pembrolizumab, Low Dose Radiation Therapy - Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2026-09-01 | 2026-10-19 |
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
Showing 20 of 968. Sign in to see all of them.
Brain Neoplasms (588) · Glioblastoma (324) · Central Nervous System Neoplasms (286) · Glioma (247) · Astrocytoma (229) · Gliosarcoma (182) · Oligodendroglioma (161) · Medulloblastoma (107) · Neoplasms (92) · Ependymoma (75) · Diffuse Intrinsic Pontine Glioma (71) · Sarcoma (63) · Breast Neoplasms (61) · Meningeal Carcinomatosis (56) · Melanoma (55)
Nervous System Diseases (962) · Neoplasms by Site (918) · Neoplasms (876) · Central Nervous System Diseases (691) · Brain Diseases (682) · Neoplasms by Histologic Type (656) · Neoplasms, Nerve Tissue (619) · Central Nervous System Neoplasms (579) · Neuroectodermal Tumors (563) · Neoplasms, Germ Cell and Embryonal (556) · Neoplasms, Glandular and Epithelial (545) · Neoplasms, Neuroepithelial (519) · Glioma (256) · Astrocytoma (159)
Temozolomide (97) · Radiotherapy (69) · Radiosurgery (36) · Carboplatin (29) · Bevacizumab (28) · Magnetic Resonance Spectroscopy (27) · Irinotecan (25) · Cyclophosphamide (24) · Radiation (21) · Filgrastim (20) · pembrolizumab (20) · Nivolumab (19) · Carmustine (16) · Erlotinib Hydrochloride (16) · Surgical Procedures, Operative (15)
National Cancer Institute (NCI) (113) · M.D. Anderson Cancer Center (32) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (26) · Duke University (23) · Memorial Sloan Kettering Cancer Center (23) · Children's Oncology Group (18) · City of Hope Medical Center (16) · Pediatric Brain Tumor Consortium (16) · St. Jude Children's Research Hospital (15) · Jonsson Comprehensive Cancer Center (13) · University of Florida (13) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (11) · H. Lee Moffitt Cancer Center and Research Institute (10) · Case Comprehensive Cancer Center (9) · Dana-Farber Cancer Institute (9)
United States (773) · China (65) · Canada (63) · France (46) · Australia (38) · United Kingdom (34) · Spain (31) · Germany (23) · Italy (21) · South Korea (18) · Netherlands (16) · Switzerland (16) · Denmark (13) · Belgium (12) · Japan (12)
Henry S. Friedman, MD (9) · Darell D. Bigner, MD, PhD (8) · Wenyin Shi, MD, PhD (7) · Brigitte C Widemann, M.D. (5) · John Boockvar, MD (5) · Alberto Broniscer, MD (4) · Annick Desjardins, MD (4) · Asha Das, MD (4) · David A. Reardon, MD (4) · Howard A. Fine, MD (4) · Jana Portnow (4) · Jana Portnow, MD (4)
PMID 15117425, PMID 23377664, PMID 23545055, PMID 27243238, PMID 31401903, PMID 36884302, PMID 41218853, PMID 9533527, PMID 10394416, PMID 10501910, PMID 11410496, PMID 11705489, PMID 11937001, PMID 12528778, PMID 12573762, PMID 12675312, PMID 12721262, PMID 12749708, PMID 12749710, PMID 12957454, PMID 13680158, PMID 1447744, PMID 14670747, PMID 14769136, PMID 14769140, PMID 15010069, PMID 15173079, PMID 15292713, PMID 15592836, PMID 15667958, PMID 15758009, PMID 15814645, PMID 15844174, PMID 15897941, PMID 16012795, PMID 16061868, PMID 16170172, PMID 16192602, PMID 16200343, PMID 16234526, PMID 16391300, PMID 16530701, PMID 16533779, PMID 16533878, PMID 16786120, PMID 16855840, PMID 16877733, PMID 16899365, PMID 16914576, PMID 16914578
U01CA081457 (14), UM1CA097452 (11), P30CA033572 (10), 2023 (8), U01CA062475 (8), U01CA097452 (8), U01CA137443 (7), UM1CA081457 (6), 2019 (5), U10CA025224 (5), 2017 (4), P30CA006973 (4), U01CA062399 (4), 2009 (3), 2015 (3)