8 recruiting, 1 completed, 1 enrolling by invitation, 1 not yet recruiting. 12 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Recruiting 8, Completed 1, Enrolling by invitation 1, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 4 | Recruiting 2, Completed 1, Enrolling by invitation 1 |
Follow Neoadjuvant Therapy: new trials by email Literature Review of Neoadjuvant Therapy trials Research Report on Neoadjuvant Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant CAPOX Plus Tislelizumab vs CAPOX in MSS High-Risk Locally Advanced Colon Cancer Tislelizumab, Oxaliplatin, Capecitabine - Colonic Neoplasms, Neoadjuvant Therapy | Phase 3 | Not yet recruiting | First Affiliated Hospital of Guangxi Medical University | 94 | 2025-10-01 | 2025-08-20 |
| Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer（UPGRADE-TNBC） paclitaxel polymeric micelles + carboplatin + iparomilimab and tuvonralimab - Triple-Negative Breast Cancer (TNBC), Neoadjuvant Therapy | Phase 2 / Phase 3 | Enrolling by invitation | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 32 | 2025-07-21 | 2026-08-18 |
| No Axillary Surgical Treatment in Clinically Lymph Node Negative Patients on Ultrasonography After Neoadjuvant Chemotherapy No axillary surgery, Axillary surgery - Breast Cancer, Neoadjuvant Therapy | Phase 3 | Recruiting | Seoul National University Hospital | 464 | 2025-06-04 | 2026-01-28 |
| Neoadjuvant Cadonilimab Combined With Perioperative Oxaliplatin Plus S1 for Diffuse or Mixed Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma Neoadjuvant cadonilimab combined with perioperative SOX, Neoadjuvant placebo plus perioperative SOX - Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]), Neoadjuvant Therapy | Phase 3 | Recruiting | Zuoyi Jiao | 668 | 2025-05-15 | 2025-07-10 |
| Neoadjuvant Apatinib Combined With Sintilimab and Perioperative SOX Versus Neoadjuvant Sintilimab Combined With Perioperative SOX for Intestinal Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma Neoadjuvant apatinib combined with sintilimab and perioperative SOX, Neoadjuvant sintilimab combined with perioperative SOX - Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]), Neoadjuvant Therapy | Phase 3 | Recruiting | Zuoyi Jiao | 682 | 2025-04-15 | 2025-04-22 |
| Neoadjuvant SNF Precision Therapy Phase III Targeted therapy agents: SNF2 -adebrelimab + famitinib; SNF3 -fluzoparib; SNF4 -apatinib, Chemotherapy (wP-EC) - Neoadjuvant Therapy | Phase 3 | Recruiting | Fudan University | 404 | 2025-04-08 | 2025-06-06 |
| Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy - Rectal Cancer, Total Neoadjuvant Treatment | Phase 2 / Phase 3 | Recruiting | National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos | 400 | 2025-01-06 | 2026-05-11 |
| Neoadjuvant Immunotherapy Plus Chemotherapy Followed by Concurrent Chemoradiotherapy and Consolidative Immunotherapy for Locally Advanced Non-small Cell Lung Cancer Neoadjuvant therapy, Hypo-RT and concurrent chemotherapy, CFRT and concurrent chemotherapy - Neoadjuvant Therapy, Concurrent Chemoradiotherapy | Phase 3 | Recruiting | Sun Yat-sen University | 497 | 2024-11-30 | 2025-07-24 |
| A Study of Neoadjuvant Therapy for the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma anlotinib, Thoracic radiotherapy - Neoadjuvant Therapy, Esophageal Squamous Cell Carcinoma | Phase 2 / Phase 3 | Recruiting | Army Medical Center of PLA | 266 | 2024-03-08 | 2024-04-09 |
| Evaluating the Efficacy and Safety of Pembrolizumab Plus Standard Chemotherapy in the Neoadjuvant Treatment of Local Advanced (LA) HNSCC Pembrolizumab, Cisplatin, Carboplatin - Head and Neck Squamous Cell Carcinoma, Neoadjuvant Therapy | Phase 3 | Recruiting | Beijing Tongren Hospital | 272 | 2023-05-01 | 2023-10-30 |
| Prehabilitation for Women Undergoing Pre-operative Chemotherapy for Breast Cancer Prehabilitation - Breast Cancer, Rehabilitation | Phase 2 / Phase 3 | Completed | Sunnybrook Health Sciences Centre | 63 | 2018-07-18 | 2023-04-12 |
| Aromatase Inhibitors Plus Chemotherapy vs Chemotherapy as Neoadjuvant Treatment in Postmenopausal HR(+) Breast Cancer Letrozole (Aromatase Inhibitors), AC*4-T*4 - Neoadjuvant Therapy | Phase 3 | Unknown | Zhejiang Cancer Hospital | 120 | 2016-05-01 | 2018-01-09 |
Breast Neoplasms (3) · Stomach Neoplasms (2) · Colonic Neoplasms (1) · Esophageal Squamous Cell Carcinoma (1) · Fatigue (1) · Low Anterior Resection Syndrome (1) · Postoperative Complications (1) · Radiation Injuries (1) · Rectal Neoplasms (1) · Squamous Cell Carcinoma of Head and Neck (1) · Triple Negative Breast Neoplasms (1)
Neoplasms (10) · Neoplasms by Site (10) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Gastrointestinal Diseases (5) · Gastrointestinal Neoplasms (5) · Breast Diseases (4) · Skin Diseases (4) · Skin and Connective Tissue Diseases (4) · Carcinoma (2) · Carcinoma, Squamous Cell (2) · Colonic Diseases (2) · Colorectal Neoplasms (2) · Head and Neck Neoplasms (2) · Intestinal Diseases (2)
Carboplatin (2) · Docetaxel (2) · Radiotherapy (2) · Aromatase Inhibitors (1) · Capecitabine (1) · Chemoradiotherapy (1) · Cisplatin (1) · Consolidation Chemotherapy (1) · Drug Therapy (1) · Fluorouracil (1) · Letrozole (1) · Neoadjuvant Therapy (1) · Oxaliplatin (1) · Preoperative Exercise (1) · Surgical Procedures, Operative (1)
Zuoyi Jiao (2) · Army Medical Center of PLA (1) · Beijing Tongren Hospital (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · First Affiliated Hospital of Guangxi Medical University (1) · Fudan University (1) · National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos (1) · Seoul National University Hospital (1) · Sun Yat-sen University (1) · Sunnybrook Health Sciences Centre (1) · Zhejiang Cancer Hospital (1)
China (9) · Canada (1) · Lithuania (1) · South Korea (1)
Audrius Dulskas, PhD (1) · Frances Wright, MD (1) · Hong-Jian Yang, MD. (1) · Hui Liu, Professor (1) · Jingjing Wang (1) · Sen Zhang (1) · Zhigang Huang (1)