5 completed, 4 recruiting, 4 unknown, 3 terminated. 19 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 19 | Completed 5, Recruiting 4, Unknown 4, Terminated 3, Active not recruiting 2, Withdrawn 1 |
Follow Nasal Polyps: new trials by email Literature Review of Nasal Polyps trials Research Report on Nasal Polyps
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Depemokimab Monotherapy Without Concomitant Use of Intranasal Corticosteroids (INCS) in Japanese Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Depemokimab - Nasal Polyps | Phase 4 | Recruiting | GlaxoSmithKline | 28 | 2026-07-15 | 2026-09-08 |
| Biologics in Chronic Rhinosinusitis With Nasal Polyposis Biologic Agents - Chronic Sinusitis, Nasal Polyps | Phase 4 | Recruiting | Medical University of South Carolina | 504 | 2026-06-03 | 2026-09-28 |
| Complete Remission After Treatment With Biologics for Nasal Polyps DUPIXENT®, NUCALA®, Dupi discontinuation - Nasal Polyps | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 66 | 2025-04-03 | 2025-12-05 |
| Mepolizumab and In-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). A Three Arm Study. Mepolizumab, Polypeptomy - Rhinosinusitis Chronic, Polyp, Nasal | Phase 4 | Unknown | Instituto de Investigación Marqués de Valdecilla | 75 | 2023-09-01 | 2023-06-28 |
| Mechanisms of Smell Improvement With Dupilumab. Dupilumab - Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Completed | Medical University of South Carolina | 60 | 2023-08-10 | 2026-08-05 |
| Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment Mepolizumab, Placebo - Chronic Rhinosinusitis With Nasal Polyps, Asthma | Phase 4 | Unknown | St. Paul's Sinus Centre | 90 | 2023-07-01 | 2024-04-17 |
| Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP Dupilumab Prefilled Syringe - Nasal Polyps, Staphylococcus Aureus | Phase 4 | Recruiting | University of Virginia | 20 | 2022-09-01 | 2025-04-01 |
| The Role of Budesonide Intrapolyp Injection in CRSwNP Budesonide intrapolyp injection, Budesonide nasal wash, Prednisolone tablets - CRS, Polyp, Nasal | Phase 4 | Unknown | Kafrelsheikh University | 90 | 2022-08-01 | 2022-07-26 |
| Omalizumab Efficacy in Patients With Refractory Nasal Polyps Omalizumab, SNOT22 score - Nasal Polyps | Phase 4 | Unknown | Shiraz University of Medical Sciences | 2 | 2022-06-01 | 2022-06-06 |
| Dupixent Study for Alternate Administration Dupilumab - Nasal Polyps, Sinusitis | Phase 4 | Active not recruiting | Madigan Army Medical Center | 30 | 2021-10-14 | 2025-01-17 |
| Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS Celecoxib, Placebo - Chronic Rhinosinusitis with Nasal Polyps, Aspirin-exacerbated Respiratory Disease | Phase 4 | Active not recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 44 | 2020-02-18 | 2024-10-29 |
| Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery Oxymetazoline, Epinephrine - Endoscopic Sinus Surgery, Nasal Polyps | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 20 | 2018-06-14 | 2021-01-13 |
| Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery Remifentanil, Tramadol, Metoprolol - Nasal Polyps | Phase 4 | Completed | Recep Tayyip Erdogan University | 88 | 2015-07-01 | 2023-12-20 |
| Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Montelukast, mometasone furoate nasal spray - Sinusitis, Nasal Polyps | Phase 4 | Completed | First Affiliated Hospital, Sun Yat-Sen University | 50 | 2014-06-01 | 2020-11-23 |
| An Open-label Study to Identify Molecular Markers of Steroid Resistance mometasone furoate - Nasal Polyps | Phase 4 | Terminated | Massachusetts General Hospital | 11 | 2013-07-01 | 2018-06-12 |
| Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Prednisone, Topical mometasone - Chronic Rhinosinusitis Without Nasal Polyps | Phase 4 | Terminated | Northwestern University | 9 | 2012-08-01 | 2018-03-30 |
| Compare the Effects of Fluticasone Furoate Nasal Spray vs Placebo in Patients With Nasal Polypoid Disease fluticasone furoate, placebo - Patients With Nasal Polyps | Phase 4 | Terminated | Johns Hopkins University | 7 | 2009-11-01 | 2017-09-13 |
| Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study Prednisone - Chronic Sinusitis, Rhinosinusitis | Phase 4 | Withdrawn | Northwestern University | 2008-07-01 | 2020-04-02 | |
| Medical Polypectomy and Predictors of Response Prednisolone, Placebo, fluticasone nasal drops - Nasal Polyps | Phase 4 | Completed | University of Dundee | 60 | 2004-05-01 | 2008-11-11 |
Sinusitis (3) · Asthma (2) · Agnosia (1) · Chronic Disease (1) · Paranasal Sinus Diseases (1) · Rhinosinusitis (1) · Staphylococcal Infections (1)
Nose Diseases (19) · Otorhinolaryngologic Diseases (19) · Pathological Conditions, Anatomical (19) · Pathological Conditions, Signs and Symptoms (19) · Polyps (19) · Respiratory Tract Diseases (19) · Infections (5) · Paranasal Sinus Diseases (4) · Respiratory Tract Infections (4) · Bronchial Diseases (2) · Hypersensitivity (2) · Hypersensitivity, Immediate (2) · Immune System Diseases (2) · Lung Diseases (2) · Lung Diseases, Obstructive (2)
dupilumab (4) · Mometasone Furoate (3) · mepolizumab (3) · Glucocorticoids (2) · Prednisolone (2) · Prednisone (2) · Biological Factors (1) · Budesonide (1) · Celecoxib (1) · Epinephrine (1) · Metoprolol (1) · Omalizumab (1) · Oxymetazoline (1) · Remifentanil (1) · Tramadol (1)
Medical University of South Carolina (2) · Northwestern University (2) · Copenhagen University Hospital, Rigshospitalet (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · GlaxoSmithKline (1) · Instituto de Investigación Marqués de Valdecilla (1) · Johns Hopkins University (1) · Kafrelsheikh University (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Madigan Army Medical Center (1) · Massachusetts General Hospital (1) · Recep Tayyip Erdogan University (1) · Shiraz University of Medical Sciences (1) · St. Paul's Sinus Centre (1) · The University of Texas Health Science Center, Houston (1)
United States (8) · Canada (2) · China (1) · Denmark (1) · Egypt (1) · Iran (1) · Japan (1) · Saudi Arabia (1) · Spain (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Brian J Lipworth, MD (1) · Bruce Tan, MD (1) · Daniel Hamilos, MD (1) · Larry C Borish, MD (1) · Leigh Sowerby, MD (1) · Renee M Serra, MD (1) · Robert P Schleimer, PhD (1) · Roy F Thomas, MD (1) · Sriram Vaidyanathan, MRCS (1) · William C Yao, MD (1) · Zachary Soler, MD (1)
PMID 21357906, PMID 21676042, PMID 28870448, PMID 29337030, PMID 32524991, PMID 32579018
R37HL068546 (1)