58 completed, 21 unknown, 10 recruiting, 9 active not recruiting. 30 Phase 3, 20 Phase 4, 18 Phase 2, 6 Phase 1, 3 Early Phase 1.
Follow mepolizumab: new trials by email Literature Review of mepolizumab trials Research Report on mepolizumab
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab Mepolizumab 100 MG Injection - COPD (Chronic Obstructive Pulmonary Disease) | Phase 4 | Not yet recruiting | Western University, Canada | 36 | 2026-10-01 | 2026-08-06 |
| Beyond EOsinophils: proteoMICS to Identify Potential Biomarker of Organ Damage and Response to MEPOLIZUMAB in EGPA Mepolizumab 100 MG Injection [Nucala], Mepolizumab 300 mg - EGPA - Eosinophilic Granulomatosis With Polyangiitis, Severe Asthma | Phase 4 | Enrolling by invitation | Azienda Ospedaliero Universitaria di Cagliari | 90 | 2025-10-17 | 2026-01-15 |
| Anti-IL-5 Therapy With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery for CRSwNP Mepolizumab, Simple Polypectomy, Extended Endoscopic Sinus Surgery - Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) | Phase 4 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 360 | 2025-10-08 | 2025-10-01 |
| Long-Term Safety and Effectiveness of Mepolizumab 300 mg in Europe (Mepo LTF Study) Mepolizumab 300 mg - Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) (EGPA) | Completed | European EGPA Study Group | 299 | 2025-09-18 | 2026-10-27 | |
| Effectiveness on Sino-Nasal Symptoms Of Mepolizumab 300 Mepolizumab 300 mg - Sinus Disease, EGPA - Eosinophilic Granulomatosis With Polyangiitis | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 52 | 2025-09-12 | 2026-05-18 | |
| Complete Remission After Treatment With Biologics for Nasal Polyps DUPIXENT®, NUCALA®, Dupi discontinuation - Nasal Polyps | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 66 | 2025-04-03 | 2025-12-05 |
| Mepolizumab and in Office-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). surgical arm, Mepolizumab 100 MG, combined arm - Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Recruiting | Instituto de Investigación Marqués de Valdecilla | 75 | 2024-12-31 | 2026-09-11 |
| Safety and Efficacy of Meplazumab in Patients With Coronary Artery Disease Mepolizumab low dose group, Mepolizumab middle dose group, Mepolizumab high dose group - Coronary Artery Disease | Phase 2 | Recruiting | Xijing Hospital | 18 | 2024-10-16 | 2026-01-23 |
| BIOlogics in Severe Nasal POlyposis SurvEy.: a French Registry Biologic treatments available in Chronic Rhinosinusitis with Nasal Polyps (dupilumab, mepolizumab and benralizumab according to their marketing approval). - Rhinosinusitis Chronic, Nasal Polyps | Not applicable | Recruiting | University Hospital, Lille | 900 | 2024-07-11 | 2026-05-18 |
| th2 Modulation CRSwNP Mepolizumab - Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Unknown | St. Paul's Sinus Centre | 40 | 2024-06-01 | 2024-04-17 |
| REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study Mepolizumab, Spirometry - Asthma | Phase 4 | Active not recruiting | GlaxoSmithKline | 336 | 2024-03-20 | 2025-08-01 |
| Biomarkers of Response to Mepolizumab Treatment in Patients With Nasal Polyps With or Without Bronchial Asthma Mepolizumab 100 MG [Nucala] - Chronic Rhinosinusitis With Nasal Polyps, Asthma | Recruiting | Aristotle University Of Thessaloniki | 57 | 2024-02-23 | 2024-03-08 | |
| Mepolizumab in the Treatment of Patients With Severe Uncontrolled CRSwNP: a Multicentric Real Life Observational Study Mepolizumab Auto-Injector - Chronic Rhinosinusitis With Nasal Polyps | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 199 | 2024-02-05 | 2024-02-14 | |
| Fluctuation Analyses of Asthma Patients With Biologics Use Biological Drug - Asthma | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 48 | 2023-12-01 | 2023-11-01 | |
| A Study to Evaluate the Efficacy and Safety of SHR-1703 in Subjects With Eosinophilic Granulomatosis With Polyangiitis （EGPA） SHR-1703, Mepolizumab Injection - Eosinophilic Granulomatosis With Polyangiitis | Phase 2 / Phase 3 | Recruiting | Guangdong Hengrui Pharmaceutical Co., Ltd | 166 | 2023-11-16 | 2025-12-04 |
| Taiwan Severe Asthma Biologic Registry Biological Treatment for severe asthma patients - Pulmonary Disease, Asthma | Recruiting | Taichung Veterans General Hospital | 500 | 2023-11-11 | 2026-05-19 | |
| Identifying Predictors Of Response To Mepolizumab In CRSwNP Mepolizumab 100 MG Injection - Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Active not recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 36 | 2023-10-03 | 2026-08-31 |
| The Role of IL5 in Epithelial Cell Integrity Mepolizumab - Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis) | Early Phase 1 | Completed | Johns Hopkins University | 17 | 2023-09-05 | 2026-07-06 |
| Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma Mepolizumab 100 MG - Chronic Rhinosinusitis With Nasal Polyps, Severe Eosinophilic Asthma | Active not recruiting | National and Kapodistrian University of Athens | 40 | 2023-09-01 | 2026-04-17 | |
| Mepolizumab and In-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). A Three Arm Study. Mepolizumab, Polypeptomy - Rhinosinusitis Chronic, Polyp, Nasal | Phase 4 | Unknown | Instituto de Investigación Marqués de Valdecilla | 75 | 2023-09-01 | 2023-06-28 |
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Asthma (48) · Pulmonary Eosinophilia (21) · Churg-Strauss Syndrome (13) · Nasal Polyps (10) · Pulmonary Disease, Chronic Obstructive (8) · Hypereosinophilic Syndrome (7) · Eosinophilia (6) · Inflammation (4) · Eosinophilic Esophagitis (2) · Esophagitis (2) · Infections (2) · Virus Diseases (2) · Angioedema (1) · Asthma, Aspirin-Induced (1) · Bronchiectasis (1)
GlaxoSmithKline (35) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Aristotle University Of Thessaloniki (2) · Copenhagen University Hospital, Rigshospitalet (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Instituto de Investigación Marqués de Valdecilla (2) · Mayo Clinic (2) · McMaster University (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · St. Paul's Sinus Centre (2) · University Hospital, Lille (2) · Assistance Publique - Hôpitaux de Paris (1) · AstraZeneca (1) · Azienda Ospedaliero Universitaria di Cagliari (1) · Bio-Thera Solutions (1)
United States (36) · Canada (31) · France (26) · Germany (24) · United Kingdom (22) · Italy (21) · Belgium (17) · Spain (17) · Australia (15) · Netherlands (15) · Japan (13) · Argentina (12) · Poland (12) · Russia (10) · Greece (9)
Catherine Lemiere, MD (2) · Jason C Sluzevich, M.D. (2) · Michael Wechsler, MD (2) · Adnan Azim, MBBS (1) · Audrey Lehmann, Ph (1) · Chao Gao, M.D., Ph.D. (1) · Christian Pedersen, MD (1) · Christian von Buchwald (1) · Christopher Brightling (1) · Dagmar Simon (1) · Daniel J Jackson, MD (1) · Eleni Loutrari, PhD (1) · Elisabeth H Bel, MD, PhD (1)
PMID 30954640, PMID 28514601, PMID 28893134, PMID 30370691, PMID 30876830, PMID 31047111, PMID 31295674, PMID 31362741, PMID 31447130, PMID 31507641, PMID 31798645, PMID 33710614, PMID 34098955, PMID 34163157, PMID 34389506, PMID 18344568, PMID 19264687, PMID 19828470, PMID 20542323, PMID 20810155, PMID 2202307, PMID 24337046, PMID 25199060, PMID 27087007, PMID 27239557, PMID 27553751, PMID 27820746, PMID 28298405, PMID 28395936, PMID 28433687, PMID 28544140, PMID 28583260, PMID 28862877, PMID 29290515, PMID 29453280, PMID 29548297, PMID 29751154, PMID 29949045, PMID 30049739, PMID 30406948, PMID 30453867, PMID 30461531, PMID 30881051, PMID 31251094, PMID 31277742, PMID 31719529, PMID 32077450, PMID 32101904, PMID 32128424, PMID 32347992
2014 (3), 2015 (3), 2016 (3), 2023 (2), 2008 (1), 2017 (1), 2019 (1), UM1AI114271 (1)