111 completed, 73 unknown, 33 recruiting, 14 active not recruiting. 116 Not applicable, 33 Phase 2, 13 Phase 1, 13 Phase 4, 11 Phase 3.
Follow NAFLD: new trials by email Literature Review of NAFLD trials Research Report on NAFLD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease Empagliflozin 10 MG, Placebo Oral Tablet - Non-Alcoholic Fatty Liver Disease, NAFLD | Phase 2 | Not yet recruiting | Justin Ryder | 40 | 2027-05-01 | 2026-01-20 |
| RE and Probiotics in MAFLD/NAFLD physical exercise programme, probiotics supplementation, Placebo - NASH, NAFLD | Not applicable | Not yet recruiting | Nicolaus Copernicus University | 180 | 2026-11-10 | 2026-10-21 |
| The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease 5-methyltetrahydrofolate (5-MTHF), placebo group - Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD) | Not applicable | Not yet recruiting | Tabriz University of Medical Sciences | 44 | 2026-09-30 | 2026-07-31 |
| GLP-1 RA on Liver OMICS in MASLD GLP-1 receptor agonist - NAFLD, Diabetes | Withdrawn | Medical College of Wisconsin | 2026-07-01 | 2026-07-13 | ||
| Accurate Point of Care Liver Disease Diagnostics (Phase 2) LiverScope® exam, MR exam, Blood draw - MASLD, MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) | Recruiting | University of California, San Diego | 26 | 2026-04-08 | 2026-04-09 | |
| Chrononutrition/ Chronotoxicity Intervention in People With Metabolic-associated Steatotic Liver Disease. Diet-Time-restricted eating (TRE), Lifestyle Management - MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease | Not applicable | Not yet recruiting | Cyprus University of Technology | 150 | 2026-01-05 | 2025-11-19 |
| Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals Caloric restriction intervention, No intervention - NAFLD | Not applicable | Recruiting | Steno Diabetes Center Copenhagen | 8 | 2026-01-01 | 2026-05-04 |
| Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) Rutin + Vitamin C, Vitamin C 500mg, Lifestyle Intervention - NAFLD | Phase 2 | Not yet recruiting | Ain Shams University | 120 | 2026-01-01 | 2025-12-30 |
| Bariatric Embolization of Arteries for the Treatment of Nonalcoholic Steatohepatitis Embospheres Microspheres - Obesity, Weight Loss | Not applicable | Not yet recruiting | Keith Pereira, MD: | 8 | 2025-12-01 | 2025-07-28 |
| The Improvement Effect of Henggliejin on Fatty Liver in Type 2 Diabetes Patients With Nonalcoholic Fatty Liver: Addition of Hengge Liejing treatment for 48 weeks - NAFLD, Diabete Type 2 | Early Phase 1 | Not yet recruiting | Fujian Medical University Union Hospital | 149 | 2025-11-01 | 2025-09-30 |
| Evaluation of a New Ultrasound System for the Non-invasive Assessment of Liver Steatosis in MASLD/MASH Patients Liver ultrasound - Metabolic Syndrome X, Fatty Liver | Not applicable | Recruiting | E-Scopics | 120 | 2025-07-24 | 2025-08-15 |
| The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Pectin, Cocoa Powder, Magnetic Resonance Imaging with Contrast - Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD) | Not applicable | Recruiting | University of Nottingham | 45 | 2025-06-10 | 2026-07-29 |
| Digoxin In NASH (CODIN) Digoxin, Placebo - NASH, NAFLD | Phase 2 | Recruiting | Yale University | 144 | 2025-06-05 | 2026-05-26 |
| Hepatic Elastography-Enhanced Lifestyle Modification in MASLD Regular monitoring with transient elastography - Transient Elastography, MASLD | Not applicable | Enrolling by invitation | Mahidol University | 92 | 2025-05-12 | 2025-05-13 |
| Secondary and Tertiary Digital Prevention of Non-alcoholic and Dysmetabolic Liver Disease NASH, NAFLD | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 252 | 2025-01-16 | 2026-09-17 | |
| Intermittent Fasting, Mediterranean Diet and NAFLD Intermittent Fasting - NAFLD, Obesity | Not applicable | Not yet recruiting | Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis | 60 | 2025-01-01 | 2024-10-26 |
| Optimizing Noninvasive assessMent Of DysmEtabolic Compensated Advanced Liver Disease extra blood sampling - NASH, NAFLD | Not applicable | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 408 | 2024-12-06 | 2026-09-02 |
| Prevalence of Non-Alcoholic Fatty Liver Disease in Inflammatory Bowel Disease Patients Transient elastometry - NAFLD, Inflammatory Bowel Diseases | Recruiting | Centre Hospitalier Universitaire Saint Pierre | 150 | 2024-11-01 | 2025-02-07 | |
| The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD. Encourage using pedometer - Daily Step Count, MASLD | Not applicable | Enrolling by invitation | Mahidol University | 86 | 2024-08-01 | 2025-05-15 |
| A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) Efinopegdutide, Placebo - Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis | Phase 2 | Completed | Merck Sharp & Dohme LLC | 85 | 2024-07-12 | 2026-09-21 |
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Non-alcoholic Fatty Liver Disease (260) · Obesity (60) · Fatty Liver (42) · Diabetes Mellitus, Type 2 (27) · Liver Cirrhosis (25) · Metabolic Syndrome (22) · Insulin Resistance (16) · Diabetes Mellitus (14) · Fibrosis (12) · Liver Diseases (12) · Cardiovascular Diseases (10) · Overweight (10) · Dyslipidemias (9) · Inflammation (9) · Pediatric Obesity (9)
Digestive System Diseases (258) · Liver Diseases (248) · Fatty Liver (218) · Nutritional and Metabolic Diseases (114) · Pathological Conditions, Signs and Symptoms (107) · Signs and Symptoms (74) · Body Weight (73) · Nutrition Disorders (71) · Overnutrition (71) · Metabolic Diseases (70) · Glucose Metabolism Disorders (63) · Overweight (61) · Endocrine System Diseases (44) · Pathologic Processes (42) · Hyperinsulinism (33)
Exercise (9) · Diet (6) · empagliflozin (6) · Diet Therapy (5) · Hematologic Tests (5) · Surveys and Questionnaires (5) · Bariatric Surgery (4) · Magnetic Resonance Imaging (4) · Vitamin E (4) · Caloric Restriction (3) · Elasticity Imaging Techniques (3) · saroglitazar (3) · semaglutide (3) · Absorptiometry, Photon (2) · Ascorbic Acid (2)
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis (9) · German Institute of Human Nutrition (5) · University of Oxford (5) · Assiut University (4) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (4) · Ain Shams University (3) · Bambino Gesù Hospital and Research Institute (3) · Cairo University (3) · Charite University, Berlin, Germany (3) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (3) · Gannex Pharma Co., Ltd. (3) · Maastricht University Medical Center (3) · Massachusetts General Hospital (3) · University Hospital, Angers (3) · University of California, San Francisco (3)
United States (76) · Italy (27) · Germany (16) · United Kingdom (15) · France (13) · Egypt (12) · China (11) · Canada (10) · Belgium (8) · Netherlands (8) · India (7) · Czechia (6) · Finland (6) · Israel (6) · Spain (6)
Alberto R Osella, MD, PhD (3) · Luca Miele (3) · Andreas FH Pfeiffer, Prof. Dr. (2) · Claude B Sirlin, MD (2) · Endrit Shahini, MD (2) · Leanne Hodson, PhD (2) · Radwa Farag, MD (2) · Samer Gawrieh, MD (2) · Stephen Harrison, MD (2) · Aase Handberg, Prof MD DMSc (1) · Adam Vasura, MD (1) · Adrian Di Bisceglie, MD,FACP,FAASLD (1)
PMID 19827166, PMID 24042449, PMID 28346567, PMID 12198701, PMID 12941756, PMID 14739871, PMID 15479938, PMID 15942443, PMID 16061080, PMID 16336439, PMID 17327354, PMID 17476864, PMID 17581899, PMID 17679036, PMID 17986716, PMID 18796671, PMID 18820647, PMID 18972405, PMID 19444870, PMID 19726018, PMID 20460906, PMID 21206486, PMID 21618575, PMID 21849603, PMID 22013734, PMID 22215166, PMID 22297845, PMID 22367009, PMID 22488764, PMID 22958053, PMID 23266543, PMID 23294957, PMID 23396737, PMID 23747244, PMID 23930163, PMID 24187469, PMID 24462005, PMID 25040896, PMID 25145475, PMID 25285192, PMID 25349724, PMID 25580206, PMID 26373167, PMID 26378644, PMID 26493259, PMID 26610348, PMID 26629307, PMID 26707365, PMID 26797718, PMID 26879684
R01DK121378 (2), R01DK134633 (2), 2018 (1), 2019 (1), 2023 (1), K23DK115827 (1), K23DK131290 (1), P30DK040561 (1), P30DK056336 (1), R01DK115987 (1), R01DK116231 (1), R01DK120612 (1), R01DK124417 (1), R01DK134624 (1), R01DK135645 (1)