5 completed, 2 terminated, 2 withdrawn, 1 active not recruiting. 3 Not applicable, 2 Early Phase 1, 2 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 2, Active not recruiting 1 |
| Early Phase 1 | 2 | Terminated 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
| Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Withdrawn 1 |
| Phase 4 | 1 | Completed 1 |
Follow Morphea: new trials by email Literature Review of Morphea trials Research Report on Morphea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases UVA-1 Phototherapy - Scleroderma, Systemic, Morphea | Not applicable | Active not recruiting | University of Utah | 30 | 2021-06-07 | 2026-10-30 |
| The Influence of Extracorporeal Photopheresis on Skin Sclerosis Scleroderma, Systemic, Graft Vs Host Disease | Completed | Charite University, Berlin, Germany | 6 | 2021-02-12 | 2022-11-17 | |
| Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease hyaluronidase injected intradermally - Microstomia, Scleroderma | Early Phase 1 | Withdrawn | Brigham and Women's Hospital | 2020-01-01 | 2021-01-14 | |
| A Study of FCX-013 Plus Veledimex for the Treatment of Moderate to Severe Localized Scleroderma (Morphea) FCX-013, veledimex - Morphea, Scleroderma, Localized | Phase 1 / Phase 2 | Terminated | Castle Creek Biosciences, LLC. | 1 | 2019-12-18 | 2024-01-23 |
| Pain Outcomes Following Intralesional Corticosteroid Injections Corticosteroid with lidocaine, Corticosteroid with normal saline - Keloid, Alopecia Areata | Phase 4 | Completed | Vanderbilt University Medical Center | 31 | 2018-10-01 | 2021-03-11 |
| Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea Crisaborole - Morphea | Phase 2 | Completed | Duke University | 8 | 2018-09-01 | 2021-04-01 |
| Molecular Effects of Topical Calcipotriene on Morphea topical calcipotriene 0.005% ointment - Morphea, Localized Scleroderma | Early Phase 1 | Terminated | Northwestern University | 2 | 2015-03-01 | 2018-09-13 |
| Genetic Variants in Linear Localized Scleroderma skin biopsy - Morphea | Not applicable | Completed | University Children's Hospital, Zurich | 50 | 2014-08-01 | 2020-11-10 |
| Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for Morphea UVA-1 Phototherapy, Placebo - Scleroderma, Localized, Morphea | Not applicable | Completed | University of Texas Southwestern Medical Center | 14 | 2012-05-01 | 2019-09-25 |
| Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository Morphea - Scleroderma, Localized, Morphea | Recruiting | University of Texas Southwestern Medical Center | 500 | 2007-05-01 | 2026-05-12 | |
| Imiquimod 5% Cream in Plaque-type Morphea: A Pilot, Prospective Open-label Study imiquimod 5% cream (Aldara) - Morphea | Phase 3 | Withdrawn | University of Alberta | 2005-11-01 | 2015-04-23 |
Scleroderma, Localized (11) · Graft vs Host Disease (2) · Scleroderma, Diffuse (2) · Scleroderma, Systemic (2) · Acne Vulgaris (1) · Alopecia Areata (1) · CREST Syndrome (1) · Cicatrix, Hypertrophic (1) · Dermoid Cyst (1) · Eosinophilic Fasciitis (1) · Granuloma Annulare (1) · Keloid (1) · Keratoacanthoma (1) · Lichen Planus (1) · Microstomia (1)
Connective Tissue Diseases (11) · Skin Diseases (11) · Skin and Connective Tissue Diseases (11) · Immune System Diseases (2) · Scleroderma, Systemic (2) · Acneiform Eruptions (1) · Alopecia (1) · Calcinosis (1) · Calcium Metabolism Disorders (1) · Cardiovascular Diseases (1) · Cicatrix (1) · Collagen Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Cysts (1)
Adrenal Cortex Hormones (1) · Drug Delivery Systems (1) · Imiquimod (1) · Lidocaine (1) · Ointments (1) · Saline Solution (1) · calcipotriene (1) · crisaborole (1) · veledimex (1)
University of Texas Southwestern Medical Center (2) · Brigham and Women's Hospital (1) · Castle Creek Biosciences, LLC. (1) · Charite University, Berlin, Germany (1) · Duke University (1) · Northwestern University (1) · University Children's Hospital, Zurich (1) · University of Alberta (1) · University of Utah (1) · Vanderbilt University Medical Center (1)
United States (7) · Canada (1) · Germany (1) · Switzerland (1)
Adela Cardones, MD (1) · Brian Drolet, MD (1) · Christopher B. Hansen, M.D. (1) · Heidi Jacobe, MD (1) · Heidi Jacobe, MD, MSCS (1) · Lisa Weibel, MD (1) · Marlene T Dytoc, MD PhD (1) · Ulrike Blume-Peytavi, Prof. MD (1)