9 completed, 4 recruiting, 3 terminated, 1 active not recruiting. 5 Not applicable, 5 Phase 2, 3 Phase 3, 1 Phase 1, 1 Phase 4.
Follow Mixed Connective Tissue Disease: new trials by email Literature Review of Mixed Connective Tissue Disease trials Research Report on Mixed Connective Tissue Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders Creating Health Online Course, Delayed access to Creating Health Online Course - Rheumatoid Arthritis, Sjogren's Syndrome | Not applicable | Recruiting | Terry L. Wahls | 400 | 2025-12-01 | 2026-08-10 |
| Intralesional Injection of STS in Treatment of Calcinosis Sodium Thiosulfate (STS) - Systemic Sclerosis (SSc), Dermatomyositis | Phase 2 | Recruiting | Robyn T. Domsic, MD, MPH | 20 | 2025-03-17 | 2026-05-05 |
| Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism Questionnaire - Arthritis, Rheumatoid, Spondylitis, Ankylosing | Completed | University Hospital, Bordeaux | 318 | 2023-07-24 | 2026-08-24 | |
| Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity Resource sheets, Community Resource Specialist, Nurse Navigator - Rheumatoid Arthritis, Palindromic Arthritis | Not applicable | Active not recruiting | Brigham and Women's Hospital | 101 | 2023-03-01 | 2025-10-15 |
| A Study to Evaluate the Safety, Tolerability and Efficacy of MHV370 in Participants With Sjogren's Syndrome (SjS) or Mixed Connective Tissue Disease (MCTD) MHV370, Placebo - Sjogren Syndrome, Mixed Connective Tissue Disease | Phase 2 | Terminated | Novartis Pharmaceuticals | 30 | 2021-11-30 | 2024-10-09 |
| Rheumatology Patient Registry and Biorepository Rheumatic Diseases, Adult Onset Still Disease | Recruiting | Yale University | 5000 | 2020-08-04 | 2026-02-13 | |
| Yellow Fever Vaccine in Patients With Rheumatic Diseases Yellow Fever vaccine (17D) - Systemic Lupus, Rheumatoid Arthritis | Not applicable | Completed | University of Sao Paulo General Hospital | 600 | 2018-01-31 | 2019-04-26 |
| New Orleans Pulmonary Hypertension Biobank No intervention. Biospecimen collection only - Pulmonary Hypertension, Systemic Sclerosis | Recruiting | Louisiana State University Health Sciences Center in New Orleans | 450 | 2017-12-29 | 2021-09-10 | |
| Safety and Efficacy of Adipose Derived Stem Cells in Refractory Rheumatoid Arthritis, Systemic Lupus Erythematosus or Sharp's Syndrome Intravenous injection of Stromal Vascular Fraction Cells (SVF) containing ADSCs, Lipoaspiration - Systemic Lupus Erythematosus, Rheumatoid Arthritis | Phase 1 | Terminated | Arkansas Heart Hospital | 2 | 2015-12-01 | 2017-03-03 |
| Role of Mesenchymal Stem Cells in Fat Grafting Fat graft enriched with ex vivo expanded stem cells, Fat graft not enriched with ex vivo expanded stem cells - Romberg's Disease, Craniofacial Microsomia | Not applicable | Unknown | King Edward Medical University | 30 | 2015-08-01 | 2015-07-10 |
| Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD Rituximab, Cyclophosphamide - Interstitial Lung Disease, Scleroderma | Phase 2 / Phase 3 | Completed | Royal Brompton & Harefield NHS Foundation Trust | 104 | 2014-11-01 | 2021-10-07 |
| A Clinical Trial for CTD-ILD Treatment N-Acetylcysteine - Interstitial Lung Disease, Connective Tissue Disease | Phase 2 / Phase 3 | Terminated | University of Michigan | 5 | 2011-12-01 | 2017-04-06 |
| Auto-immunity and Pulmonary Arterial Hypertension skin biopsy, Blood Sample - Pulmonary Arterial Hypertension, HIV Infection | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 629 | 2010-06-15 | 2026-03-27 |
| The CARRA Registry Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus | Completed | Duke University | 9587 | 2009-08-01 | 2015-11-17 | |
| Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus Mixed Connective Tissue Disease (MCTD), Systemic Lupus Erythematosus (SLE) | Completed | University of Miami | 124 | 2007-10-01 | 2026-03-19 | |
| CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study Connective Tissue Diseases, Blood Coagulation Disorders | Completed | George Washington University | 40 | 2007-08-01 | 2017-08-30 | |
| Alendronate Osteoporosis Study Alendronate - Glucocorticoid-Associated Osteopenia and Osteoporosis | Phase 2 / Phase 3 | Completed | Boston Children's Hospital | 20 | 2003-03-01 | 2017-04-11 |
| Safety and Efficacy of Pletal (Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaud's Phenomenon Pletal - Raynaud's Disease | Phase 4 | Completed | Otsuka America Pharmaceutical | 75 | 2001-10-01 | 2005-07-19 |
Lupus Erythematosus, Systemic (9) · Scleroderma, Systemic (9) · Arthritis, Rheumatoid (8) · Sjogren's Syndrome (8) · Dermatomyositis (7) · Arthritis, Juvenile (4) · Connective Tissue Diseases (4) · Scleroderma, Diffuse (4) · Arthritis, Psoriatic (3) · Polymyositis (3) · Spondylitis, Ankylosing (3) · Arthritis (2) · Lung Diseases, Interstitial (2) · Myositis (2)
Skin and Connective Tissue Diseases (18) · Musculoskeletal Diseases (15) · Skin Diseases (15) · Connective Tissue Diseases (14) · Autoimmune Diseases (13) · Immune System Diseases (13) · Joint Diseases (12) · Arthritis (10) · Rheumatic Diseases (10) · Mouth Diseases (9) · Stomatognathic Diseases (9) · Dry Eye Syndromes (8) · Eye Diseases (8) · Lacrimal Apparatus Diseases (8) · Nervous System Diseases (8)
Acetylcysteine (1) · Alendronate (1) · Blood Specimen Collection (1) · Cilostazol (1) · Cyclophosphamide (1) · Rituximab (1) · Surveys and Questionnaires (1) · Tissue Transplantation (1) · Yellow Fever Vaccine (1) · sodium thiosulfate (1)
Arkansas Heart Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Boston Children's Hospital (1) · Brigham and Women's Hospital (1) · Duke University (1) · George Washington University (1) · King Edward Medical University (1) · Louisiana State University Health Sciences Center in New Orleans (1) · Novartis Pharmaceuticals (1) · Otsuka America Pharmaceutical (1) · Robyn T. Domsic, MD, MPH (1) · Royal Brompton & Harefield NHS Foundation Trust (1) · Terry L. Wahls (1) · University Hospital, Bordeaux (1) · University of Miami (1)
United States (11) · France (2) · Brazil (1) · China (1) · Germany (1) · Hungary (1) · Poland (1) · Spain (1) · Taiwan (1) · United Kingdom (1)
Candace H Feldman, MD, MPH, ScD (1) · Carol Wallace, MD (1) · Catherine Gordon, MD (1) · Christy Sandborg, MD (1) · Eloisa Bonfa, MD, PhD (1) · Eric L. Greidinger, MD (1) · Gerardo Rodriguez, MD PhD (1) · Laura Schanberg, MD (1) · Luc Mouthon, MD, PhD (1) · Monique Hinchcliff, MD (1) · Norman T Illowite, MD (1) · Robyn T Domsis, MD (1) · Terry L Wahls, MD, Other (1)
PMID 15942915, PMID 22227955, PMID 22733975, PMID 22859354, PMID 23070991, PMID 23139240, PMID 23588937, PMID 28399931, PMID 28619061, PMID 31827528, PMID 34843469, PMID 36375479, PMID 40747756, PMID 40787733, PMID 41680954, PMID 42035038
P50AR080612 (1), R01AR043308 (1)