123 completed, 13 recruiting, 11 terminated, 10 unknown. 166 Phase 2, 34 Phase 3, 25 Phase 1.
Follow Metabolic Syndrome: new trials by email Literature Review of Metabolic Syndrome trials Research Report on Metabolic Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus Semaglutide (Wegovy) weekly injection - Gestational Diabetes Mellitus (GDM), Metabolic Syndrome | Phase 2 / Phase 3 | Not yet recruiting | University of Massachusetts, Worcester | 226 | 2027-09-01 | 2026-09-28 |
| Effects of Meal Macronutrients on Postprandial Lipids High carb then high fat breakfast, High fat then high carb breakfast - Nephrotic Syndrome, Lipodystrophy | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 100 | 2026-11-01 | 2026-10-27 |
| Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI) Galantamine Hydrobromide Extended Release - Spinal Cord Injury, Traumatic Spinal Cord Injury | Phase 2 / Phase 3 | Recruiting | Northwell Health | 60 | 2026-06-15 | 2026-06-04 |
| No Guts No Glory Probiotics Probiotic Formula, Placebo - Patients Using Olanzapine, Quetiapine, Risperidone or Clozapine | Phase 2 / Phase 3 | Recruiting | University Medical Center Groningen | 112 | 2026-06-01 | 2026-05-26 |
| MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity MOTS-c (MDP), Placebo, Route Subcutaneous injection - Prediabetes, Insulin Resistance | Phase 2 | Recruiting | Hudson Biotech | 120 | 2026-02-02 | 2026-04-01 |
| Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health Time-restricted eating (TRE) + Standard of Care, Standard of Care - Metabolic Syndrome, Pre-diabetes | Phase 2 | Recruiting | University of California, San Diego | 140 | 2025-10-23 | 2026-02-02 |
| Effect of Empagliflozin on Metabolic Outcomes in Adults Living With HIV Receiving Dolutegravir-Based Therapy Empagliflozin (oral), Placebo - Metabolic Syndrome, Obesity & Overweight | Phase 2 | Recruiting | Abdelrahman Mahmoud | 66 | 2025-09-01 | 2026-01-13 |
| Effect of Sinbiotic With Multispecies Probiotics on Liver Parameters Liver Enzymes, Ultrasound, Elastography and Adipokines in Same Cases) in Patients With Metabolic Associated Steatotic Liver Disease. The test product is a ready-to-use sinbiotic preparation of multispecies probiotics, ca-butyrate and FOS, Placebo Drug - MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Diabetes Mellitus | Phase 2 | Not yet recruiting | Eva Cubric | 114 | 2025-07-01 | 2025-06-18 |
| Combined Oral Contraceptive Pill and Resistance Starch wheat dextrin, Oral Contraceptives, Low-Dose, Maltodextrin - Metabolic Syndrome, Polycystic Ovary Syndrome | Phase 2 | Recruiting | University of Pennsylvania | 100 | 2025-06-10 | 2026-06-01 |
| Hyperbaric Oxygen Therapy on Insulin Resistance in Postmenopause Hyperbaric oxygen therapy, Hypoglycemic Drug - Insulin Resistance Syndrome | Phase 1 / Phase 2 | Recruiting | Cairo University | 40 | 2025-01-28 | 2025-02-04 |
| Integrated Traditional Chinese Medicine Day Care Program for Metabolic Syndrome A fiixed combination of Chinese herbal medicine, Laser acupuncture - Obesity, Metabolic Syndrome | Phase 1 / Phase 2 | Recruiting | Chang Gung Memorial Hospital | 200 | 2024-11-20 | 2024-11-25 |
| Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body Hyperpolarized 13C-pyruvate - Heart Failure, Cardiometabolic Syndrome | Phase 2 | Recruiting | National Heart Centre Singapore | 200 | 2024-10-17 | 2024-12-06 |
| Testing MitoQ on Lower Urinary Tract Symptoms in Older Women With Metabolic Syndrome MitoQ (mitoquinol mesylate), Placebo - Lower Urinary Tract Symptoms, Overactive Bladder Syndrome | Phase 2 | Terminated | Iman Al-Naggar, PhD | 20 | 2024-04-03 | 2026-05-01 |
| COMMETS- Combination MCI Metabolic Syndrome Semaglutide, Intranasal insulin, Semaglutide placebo - Alzheimer Disease, Mild Cognitive Impairment | Phase 2 | Recruiting | Rutgers, The State University of New Jersey | 80 | 2024-01-30 | 2026-07-27 |
| Polyamine Treatment in Elderly Patients With Coronary Artery Disease Spermidine, Placebo - Ischemic Heart Disease, Myocardial Infarction | Phase 2 | Completed | University of Aarhus | 187 | 2024-01-01 | 2026-07-01 |
| Study of INV-202 in Patients With Obesity and Metabolic Syndrome INV-202, Placebo - Obesity, Metabolic Syndrome | Phase 2 | Completed | Inversago Pharma Inc. | 243 | 2023-09-08 | 2025-06-05 |
| The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function Empagliflozin 25 MG, Placebo - Obesity, Metabolic Syndrome | Phase 1 / Phase 2 | Recruiting | Vanderbilt University Medical Center | 74 | 2023-09-06 | 2026-09-01 |
| Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction Vericiguat, Placebo - Metabolic Syndrome, Coronary Microvascular Dysfunction | Phase 2 | Completed | Johns Hopkins University | 45 | 2023-06-16 | 2026-01-27 |
| Effect of Celery Seed on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion Celery Seed, Placebo - Metabolic Syndrome | Phase 2 | Recruiting | University of Guadalajara | 28 | 2023-05-20 | 2024-10-23 |
| Effect of Oral 6-bromotryptophan on Safety, Pharmacokinetics and Efficacy in Metabolic Syndrome Individuals 6-BT, Placebo - Metabolic Syndrome, Diabetes Mellitus | Phase 1 / Phase 2 | Unknown | Nordin Hanssen | 36 | 2023-05-04 | 2023-08-22 |
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Insulin Resistance (46) · Obesity (38) · Diabetes Mellitus (20) · Diabetes Mellitus, Type 2 (20) · Hypertension (19) · Inflammation (13) · Cardiovascular Diseases (12) · Glucose Intolerance (12) · Overweight (12) · Dyslipidemias (11) · Hyperlipidemias (9) · Atherosclerosis (6) · Non-alcoholic Fatty Liver Disease (6) · Hypercholesterolemia (5)
Glucose Metabolism Disorders (166) · Hyperinsulinism (166) · Nutritional and Metabolic Diseases (165) · Metabolic Diseases (163) · Insulin Resistance (120) · Pathological Conditions, Signs and Symptoms (68) · Signs and Symptoms (57) · Body Weight (52) · Nutrition Disorders (51) · Overnutrition (50) · Endocrine System Diseases (45) · Overweight (38) · Lipid Metabolism Disorders (27) · Vascular Diseases (27) · Cardiovascular Diseases (26)
Metformin (14) · Atorvastatin (5) · Exercise (5) · Pioglitazone (4) · Rosiglitazone (4) · salicylsalicylic acid (4) · Cellulose (3) · Fish Oils (3) · Linseed Oil (3) · Resveratrol (3) · recombinant methionyl human leptin (3) · semaglutide (3) · (1-6)-alpha-glucomannan (2) · Allopurinol (2) · Aspirin (2)
University of Guadalajara (9) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (5) · Joslin Diabetes Center (4) · University of Pennsylvania (4) · Chinese Academy of Sciences (3) · National Nutrition and Food Technology Institute (3) · University of California, San Francisco (3) · University of Messina (3) · Vanderbilt University Medical Center (3) · Bambino Gesù Hospital and Research Institute (2) · Charite University, Berlin, Germany (2) · Emory University (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Florida State University (2) · Gladwin, Mark, MD (2)
United States (67) · Canada (14) · Mexico (13) · Italy (9) · Netherlands (7) · Germany (6) · China (5) · Denmark (5) · Spain (5) · Finland (4) · Sweden (4) · Australia (3) · Egypt (3) · India (3) · France (2)
Allison B. Goldfine, MD (4) · Xu Lin, MD, PhD (3) · Bahram H. Arjmandi, PhD, RD (2) · Francesco Squadrito, MD (2) · Julio Licinio, MD (2) · Kara S Hughan, MD (2) · Karen Madsen, PhD (2) · Kathleen Jablonski, PhD (2) · Mark Gladwin, MD (2) · Myrlene Staten, MD (2) · Sarah A. Johnson, PhD, RDN (2) · Steven E. Shoelson, MD, PhD (2)
PMID 19889232, PMID 20826632, PMID 21070531, PMID 25091629, PMID 10480510, PMID 10523015, PMID 10801260, PMID 10868854, PMID 10963727, PMID 11007769, PMID 11411567, PMID 11443202, PMID 11556815, PMID 11756340, PMID 11960602, PMID 12086935, PMID 12145010, PMID 12523673, PMID 12622244, PMID 12681026, PMID 12815141, PMID 1400291, PMID 14685229, PMID 15070752, PMID 15168555, PMID 15333514, PMID 15713712, PMID 15949871, PMID 16054141, PMID 16155076, PMID 16157765, PMID 16218959, PMID 16308421, PMID 16626303, PMID 16636217, PMID 16818482, PMID 16940989, PMID 16953201, PMID 1695875, PMID 17026483, PMID 17069794, PMID 17086191, PMID 17112576, PMID 17135615, PMID 17199724, PMID 17517446, PMID 17560332, PMID 17578889, PMID 17684509, PMID 17916599
U01DK074556 (2), 2005 (1), 2009 (1), 2016 (1), F32DK068902 (1), I01CX000982 (1), K23DK002858 (1), K23HL103976 (1), KL2RR024151 (1), P30AG067988 (1), P50HL083762 (1), P50HL083813 (1), R01AG018198 (1), R01AG028746 (1), R01DK041973 (1)