53 completed, 23 recruiting, 18 unknown, 12 not yet recruiting. 86 Not applicable, 11 Phase 4, 4 Phase 3, 2 Phase 2, 1 Early Phase 1.
Follow Mastectomy: new trials by email Literature Review of Mastectomy trials Research Report on Mastectomy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gender Affirming Mastectomy Analgesia Rial Paravertebral (single injection), Wide local infiltration - Gender Affirming Surgery, Mastectomy | Not applicable | Not yet recruiting | Nova Scotia Health Authority | 64 | 2027-01-01 | 2026-10-06 |
| Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy Serratus Anterior Plane Block (SAPB) group, Pectoral nerve block (PECS) - Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection | Not applicable | Not yet recruiting | Lebanese American University | 80 | 2026-12-01 | 2026-10-19 |
| Single vs Multiple Injection Intertransverse Process Block in Breast Cancer Surgery Multiple Level Intertransverse Process Block, Single Level Intertransverse Process Block - Breast Cancer, Postoperative Pain | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-11-01 | 2026-08-13 |
| Timing of Serratus Anterior Plane Block in Mastectomy Surgery Ultrasound-Guided Serratus Anterior Plane Block, Bupivacaine - Quality of Recovery After Mastectomy, Serratus Anterior Plane Block | Not applicable | Not yet recruiting | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 80 | 2026-09-01 | 2026-06-22 |
| Biological and Clinical Underpinnings of Postoperative Pain - Mastectomy Mastectomy | Not yet recruiting | University of Alabama at Birmingham | 86 | 2026-09-01 | 2026-07-13 | |
| Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal Block in Patients Undergoing Breast Cancer Surgery Serratus posterior superior intercostal plane block, Rhomboid intercostal plane block - Breast Cancer, Lymph Node Dissection | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-08-30 | 2026-05-11 |
| Reverse Fly Exercise On Supraspinatus Tendinitis In Patients Receiving Aromatase Inhibitors Therapy After Mastectomy Reverse fly excercise, Control group - Mastectomy, Aromatase Inhibitors Therapy | Not applicable | Recruiting | Cairo University | 40 | 2026-08-18 | 2026-10-06 |
| Transverse vs. Longitudinal Serratus Anterior Plane Block in Breast Surgery Transverse SAP Block, Longitudinal SAP Block - Fascial Plane Block, Pain, Postoperative | Not applicable | Recruiting | Ankara Etlik City Hospital | 70 | 2026-08-06 | 2026-08-07 |
| Analgesic Efficacy of Combined PECS II and PIP Block Versus Thoracic Paravertebral Block Post-Mastectomy Combined PECS II and Superficial PIP Block, Thoracic paravertebral block (TPVB) - Acute Pain, Post Operative Analgesia | Not applicable | Recruiting | Dharmais National Cancer Center Hospital | 72 | 2026-06-29 | 2026-07-31 |
| The Role of Amnion Membrane Allografts in Nipple Preservation AmnioFix dehydrated Human Amnion/Chorion Membrane Allograft, Control Device - Mastectomy, Gender Affirmation Surgery | Not applicable | Not yet recruiting | Stanford University | 30 | 2026-06-01 | 2026-04-30 |
| Same-Day Awake Mastectomy With Immediate Breast Reconstruction for Patients With Breast Cancer AMADeuS Perioperative Pathway, Usual Perioperative Care - Breast Cancer, Mastectomy | Not applicable | Recruiting | University of Rome Tor Vergata | 100 | 2026-04-01 | 2026-04-03 |
| Selected Exercise Program on Upper Cross Syndrome Post-unilateral Mastectomy Selected exercise program, Routine medical therapy - Mastectomy | Not applicable | Not yet recruiting | Cairo University | 60 | 2026-03-02 | 2026-03-03 |
| Interactive Design of Patient-Specific Molds for Tissue Shaping Standard of care reconstruction, Surgery, Breast Mold - Mastectomy | Not applicable | Recruiting | M.D. Anderson Cancer Center | 160 | 2026-03-02 | 2026-10-06 |
| Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome Pregabalin, Pregabalin + Amantadine, Pregabalin + Duloxetine - Amantadine, Duloxetine | Not applicable | Recruiting | Cairo University | 150 | 2026-02-21 | 2026-02-24 |
| Hybrıd Educatıon Based on Psychodynamıc Nursıng Theory of Women Undergoıng Mastectomy Psychodynamic Nursing-Based Patient Education - Breast Cancer, Mastectomy | Not applicable | Completed | Karadeniz Technical University | 69 | 2025-11-28 | 2026-05-19 |
| Investigation of the Effects of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block on Perioperative Analgesia Management in Patients Scheduled for Mastectomy SAP Block, SPSIP Block - Postoperative Pain, Nerve Block | Not applicable | Recruiting | Uludag University | 66 | 2025-10-15 | 2026-04-03 |
| Effect of Patient-Anesthesiologist Gender Concordance and Analgesia Method on Postoperative Pain in Mastectomy Patients Breast Cancer, Mastectomy | Completed | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 120 | 2025-06-16 | 2026-04-30 | |
| Effect of Kinetic Control Exercise on Shoulder Dysfunction Post Mastectomy kinetic Control exercises, traditional treatment - Kinetic Control, Dysfunction | Not applicable | Not yet recruiting | Cairo University | 60 | 2025-06-15 | 2025-06-17 |
| A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy Bionic Breast implant - Mastectomy, Breast | Not applicable | Recruiting | University of Chicago | 8 | 2025-05-14 | 2026-04-27 |
| Compassion, Social Support, Flexibility, and Resilience Program for Women Surviving Breast Cancer Resilience-Focused Acceptance and Commitment Therapy (ReACT) Program, No intervention - Breast Cancer Survivor, Mastectomy | Not applicable | Enrolling by invitation | Medipol University | 20 | 2025-04-12 | 2025-05-21 |
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Breast Neoplasms (51) · Pain, Postoperative (27) · Chronic Pain (12) · Acute Pain (10) · Agnosia (8) · Seroma (7) · Pain (5) · Anxiety Disorders (2) · Carcinoma, Intraductal, Noninfiltrating (2) · Patient Satisfaction (2) · Somatoform Disorders (2) · Adjustment Disorders (1) · Bites and Stings (1) · Carpal Tunnel Syndrome (1) · Cicatrix, Hypertrophic (1)
Pathological Conditions, Signs and Symptoms (56) · Neoplasms (52) · Breast Diseases (51) · Neoplasms by Site (51) · Skin Diseases (51) · Skin and Connective Tissue Diseases (51) · Signs and Symptoms (46) · Neurologic Manifestations (44) · Pathologic Processes (38) · Pain (36) · Postoperative Complications (26) · Nervous System Diseases (12) · Inflammation (8) · Neurobehavioral Manifestations (8) · Perceptual Disorders (8)
Dexmedetomidine (4) · Lidocaine (4) · Saline Solution (4) · Bupivacaine (3) · Control Groups (3) · Sodium Chloride (3) · Mastectomy, Simple (2) · Amantadine (1) · Analgesics, Opioid (1) · Anastrozole (1) · Anesthesia, Epidural (1) · Anesthesia, General (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Athletic Tape (1) · Auriculotherapy (1)
Cairo University (9) · Ankara Etlik City Hospital (3) · Gangnam Severance Hospital (3) · University of California, San Diego (3) · Antalya City Hospital (2) · Assiut University (2) · Centre Hospitalier Universitaire, Amiens (2) · Georgetown University (2) · Lebanese American University (2) · Stanford University (2) · University of Alabama at Birmingham (2) · Vanderbilt University Medical Center (2) · Wake Forest University Health Sciences (2) · Acibadem University (1) · AirXpanders, Inc. (1)
United States (31) · Turkey (Türkiye) (18) · Egypt (17) · France (10) · Italy (5) · Canada (4) · South Korea (4) · China (3) · Taiwan (3) · Australia (2) · Denmark (2) · Lebanon (2) · Spain (2) · United Kingdom (2) · Belgium (1)
Abdelrhman Alshawadfy, MD (1) · Adam Katz, MD (1) · Ahmed Thallaj (1) · Albine Mancaux, MD (1) · Allegri Massimo, MD (1) · Amal Abd El-Baky, Professor (1) · Andrea Moreira, MD (1) · Anthony Connell, M.D. (1) · Ariadna Huertas Zurriaga, RN (1) · Ashleigh M Francis, MD (1) · Asimina Lazaridou, PhD (1) · Asmaa Omar, Master (1)
PMID 10506676, PMID 11579339, PMID 15923270, PMID 17449890, PMID 17456685, PMID 17473369, PMID 18585963, PMID 18622068, PMID 19427625, PMID 19488550, PMID 19776028, PMID 19903919, PMID 21435953, PMID 21921761, PMID 22752881, PMID 23084155, PMID 23580693, PMID 25357043, PMID 29909577, PMID 31612292, PMID 31907649, PMID 33742323, PMID 35888675, PMID 36716896, PMID 36776410, PMID 37086524, PMID 37280082, PMID 39080545, PMID 40234881, PMID 40983823, PMID 41315952, PMID 41540334, PMID 41657582, PMID 42804167, PMID 663696, PMID 9322469, PMID 9563536
2017 (1), P30CA012197 (1), P30CA046934 (1), R01CA281301 (1), R35GM159908 (1)