22 completed, 10 unknown, 6 recruiting, 2 not yet recruiting. 24 Not applicable, 5 Phase 2, 3 Phase 3, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 24 | Completed 13, Unknown 6, Recruiting 4, Not yet recruiting 1 |
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Phase 3 | 3 | Unknown 2, Completed 1 |
| Early Phase 1 | 1 | Suspended 1 |
| Phase 1 | 1 | Completed 1 |
Follow Long Covid19: new trials by email Literature Review of Long Covid19 trials Research Report on Long Covid19
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding the Long-term Impact of COVID-19 in Adults Long COVID, Long Covid19 | Not yet recruiting | NYU Langone Health | 5205 | 2026-05-01 | 2026-03-27 | |
| Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS To Measure levels of circulating monocyte/ T cell doublets at Baseline, To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment, To measure levels of circulating monocyte/ T cell doublets after 28 days of Placebo treatment - Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS) | Phase 2 | Recruiting | Vanderbilt University Medical Center | 50 | 2025-12-18 | 2026-01-22 |
| Transcraneal Magnetic Stimulation for Treatment of Non-nociceptive Pain in Chronic Diseases Transcraneal Magnetic Stimulation (rTMS) - Stroke Sequelae, Chronic Pain | Not applicable | Completed | Hospital Donostia | 47 | 2025-10-01 | 2026-10-22 |
| Telerehabilitation of Balance Clinical and Economic Decision Support System Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program - Stroke, Mild Cognitive Impairment | Not applicable | Not yet recruiting | University College, London | 460 | 2025-09-01 | 2025-07-10 |
| Treatment of Post-COVID-19 With Hyperbaric Oxygen Therapy: a Randomized, Controlled Trial Hyperbaric oxygen - Post-COVID-19 Syndrome, Post-COVID Syndrome | Phase 3 | Unknown | Erasmus Medical Center | 120 | 2024-10-01 | 2024-02-28 |
| RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM)) Structured Pacing, Usual Care - Long COVID, Long Covid19 | Not applicable | Completed | Duke University | 300 | 2024-07-17 | 2026-10-06 |
| RECOVER-ENERGIZE Platform Protocol_Appendix A (Exercise Intolerance) Personalized Cardiopulmonary Rehabilitation, Education - Long COVID, Long Covid19 | Not applicable | Completed | Duke University | 360 | 2024-07-17 | 2026-07-08 |
| RECOVER-ENERGIZE Platform Protocol Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education - Long COVID, Long Covid19 | Not applicable | Completed | Duke University | 660 | 2024-07-17 | 2025-11-14 |
| Combined Pulmonary Rehabilitation and PMR for Long-Term COVID-19 Symptoms: A RCT Pulmonary rehabilitation protocol, Progressive muscle relaxation protocol - Long Covid19, Pulmonary Rehabilitation | Not applicable | Completed | Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara | 61 | 2024-07-15 | 2024-12-03 |
| Long-Covid-19 Alleviation Through Learning Mindfulness Study Structured mindfulness intervention - Long COVID, Long Covid19 | Not applicable | Recruiting | Columbia University | 400 | 2024-05-21 | 2026-08-31 |
| RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine) Ivabradine, Ivabradine Placebo, Coordinated Care - Long COVID, Long Covid19 | Phase 2 | Completed | Kanecia Obie Zimmerman | 181 | 2024-03-11 | 2026-02-20 |
| RECOVER-AUTONOMIC Platform Protocol IVIG + Coordinated Care, IVIG Placebo + Coordinated Care, Ivabradine + Coordinated Care - Long COVID, Long Covid19 | Phase 2 | Completed | Kanecia Obie Zimmerman | 381 | 2024-03-11 | 2026-08-03 |
| Electro-acupuncture for Long Covid Neuropsychiatric Symptoms Acupuncture, Sham-acupuncture - Long Covid19, Neuropsychiatric Symptoms | Not applicable | Unknown | Hong Kong Baptist University | 150 | 2024-03-01 | 2024-05-07 |
| Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues Liraglutide Pen Injector [Saxenda], Medication Diary - Multiple Sclerosis, Long COVID | Early Phase 1 | Suspended | University of Chicago | 30 | 2024-01-26 | 2026-03-30 |
| Symptom Tracking in Long COVID Patients Using Formula C™ Sublingual Drops Endourage Targeted Wellness Formula C™, a full hemp flower extract - Long COVID, Long Covid19 | Completed | Endourage, LLC | 20 | 2023-12-13 | 2025-02-25 | |
| IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS. Nutritional blend (ImmuneRecov). - Long Covid19, Dietary Supplements | Phase 3 | Unknown | Federal University of São Paulo | 58 | 2023-12-10 | 2023-12-12 |
| The Long COVID-19 Wearable Device Study Wearable device - Long COVID, Postural Orthostatic Tachycardia Syndrome | Not applicable | Recruiting | Scripps Translational Science Institute | 100500 | 2023-11-16 | 2025-05-11 |
| Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functioning of Persons Suffering From Post-COVID-19 Syndrome: A Randomized Controlled Trial Comprehensive Rehabilitation, Augmented Usual Care - Post-Acute COVID-19, Post-Acute COVID-19 Syndrome | Not applicable | Completed | University of Pennsylvania | 125 | 2023-11-15 | 2026-01-20 |
| Diaphragm Dysfunction After COVID-19 as Determined by Dynamic Chest Radiography dynamic chest radiography - Long Covid19 | Unknown | Nanfang Hospital, Southern Medical University | 24 | 2023-11-10 | 2023-12-26 | |
| Chronic-disease Self-management Program in Patients Living With Long-COVID in Puerto Rico "Tomando control de su salud" (Spanish Chronic Disease Self-Management) - Long Covid19 | Not applicable | Completed | University of Puerto Rico | 47 | 2023-11-02 | 2026-05-22 |
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Post-Acute COVID-19 Syndrome (43) · COVID-19 (9) · Motor Activity (4) · Autonomic Nervous System Diseases (3) · Dyspnea (3) · Fatigue Syndrome, Chronic (3) · Postural Orthostatic Tachycardia Syndrome (3) · Chronic Pain (2) · Cognitive Dysfunction (2) · Dizziness (2) · Inflammation (2) · Mental Fatigue (2) · Myalgia (2) · Anosmia (1) · Arthralgia (1)
Chronic Disease (43) · Coronaviridae Infections (43) · Disease Attributes (43) · Infections (43) · Lung Diseases (43) · Nidovirales Infections (43) · Pathologic Processes (43) · Pathological Conditions, Signs and Symptoms (43) · Pneumonia (43) · Pneumonia, Viral (43) · RNA Virus Infections (43) · Respiratory Tract Diseases (43) · Virus Diseases (43) · Coronavirus Infections (42) · Post-Infectious Disorders (42)
Acupuncture Therapy (3) · Educational Status (2) · Hyperbaric Oxygenation (2) · Ivabradine (2) · Breathing Exercises (1) · Bupivacaine (1) · Chocolate (1) · Cognitive Training (1) · Flavonoids (1) · Immunoglobulins, Intravenous (1) · Liraglutide (1) · Restore polishing paste (1) · Ritonavir (1) · Tomography, Optical Coherence (1) · Transcranial Direct Current Stimulation (1)
Duke University (5) · Kanecia Obie Zimmerman (3) · Columbia University (2) · Hong Kong Baptist University (2) · University College, London (2) · Bahçeşehir University (1) · Brugmann University Hospital (1) · Endourage, LLC (1) · Erasmus Medical Center (1) · Federal University of Paraíba (1) · Federal University of São Paulo (1) · Fundación Universidad Católica de Valencia San Vicente Mártir (1) · Guillermo Ceballos Reyes (1) · Hospital Donostia (1) · Jonathann Kuo, MD (1)
United States (20) · Brazil (2) · Germany (2) · Hong Kong (2) · Netherlands (2) · Puerto Rico (2) · Spain (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · China (1) · Greece (1) · Italy (1) · Mexico (1)
Barry Make, MD (3) · Gary M Felker, MD (3) · Janna Friedly, MD, MPH (3) · Kanecia Zimmerman, MD PhD (3) · Lucinda Bateman, MD (3) · Cyndya Shibao, MD (2) · Daniel Laskowitz, MD MHS (2) · Pam Taub, MD (2) · Peter Novak, MD (2) · Tae Chung, MD (2) · Adam DuVall, MD (1) · Alexandru Crisan, PhD (1) · Amanda Rao, PhD (1) · Anna Norweg, PhD (1)
PMID 42282195, PMID 41720282, PMID 17786266, PMID 29034226, PMID 30867063, PMID 31004219, PMID 31985934, PMID 32352407, PMID 32383624, PMID 32700055, PMID 32784198, PMID 32859477, PMID 32912793, PMID 32992048, PMID 33243837, PMID 33412596, PMID 33663640, PMID 33729021, PMID 33823720, PMID 37507580, PMID 38041762, PMID 3812275, PMID 38755688, PMID 39434179, PMID 40730806, PMID 40894014, PMID 41212544, PMID 42350021, PMID 42384384, PMID 42415070, PMID 42625188, PMID 42673984, PMID 8598068
OT2HL156812 (3), 1OT2HL156812-01 (1)