4 completed, 1 recruiting. 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
Follow Long COVID19: new trials by email Literature Review of Long COVID19 trials Research Report on Long COVID19
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS To Measure levels of circulating monocyte/ T cell doublets at Baseline, To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment, To measure levels of circulating monocyte/ T cell doublets after 28 days of Placebo treatment - Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS) | Phase 2 | Recruiting | Vanderbilt University Medical Center | 50 | 2025-12-18 | 2026-01-22 |
| RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine) Ivabradine, Ivabradine Placebo, Coordinated Care - Long COVID, Long Covid19 | Phase 2 | Completed | Kanecia Obie Zimmerman | 181 | 2024-03-11 | 2026-02-20 |
| RECOVER-AUTONOMIC Platform Protocol IVIG + Coordinated Care, IVIG Placebo + Coordinated Care, Ivabradine + Coordinated Care - Long COVID, Long Covid19 | Phase 2 | Completed | Kanecia Obie Zimmerman | 381 | 2024-03-11 | 2026-08-03 |
| RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms Experimental: Paxlovid 25 day dosing, Experimental: Paxlovid 15 day dosing, Placebo Comparator: Control - Long COVID, Long Covid19 | Phase 2 | Completed | Kanecia Obie Zimmerman | 963 | 2023-07-26 | 2025-12-02 |
| ImPROving Quality of LIFe in the Long COVID Patient Nirmatrelvir/ritonavir, Placebo/ritonavir - Post-COVID-19 Syndrome, Long COVID | Phase 2 | Completed | Karolinska Institutet | 219 | 2023-05-01 | 2024-12-04 |
Post-Acute COVID-19 Syndrome (5) · COVID-19 (2) · Postural Orthostatic Tachycardia Syndrome (2) · Post-Infectious Disorders (1)
Chronic Disease (5) · Coronaviridae Infections (5) · Coronavirus Infections (5) · Disease Attributes (5) · Infections (5) · Lung Diseases (5) · Nidovirales Infections (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Pneumonia (5) · Pneumonia, Viral (5) · RNA Virus Infections (5) · Respiratory Tract Diseases (5) · Respiratory Tract Infections (5) · Virus Diseases (5)
Ivabradine (2) · Immunoglobulins, Intravenous (1) · Ritonavir (1) · nirmatrelvir and ritonavir drug combination (1)
Kanecia Obie Zimmerman (3) · Karolinska Institutet (1) · Vanderbilt University Medical Center (1)
United States (4) · Puerto Rico (1) · Sweden (1)
Cyndya Shibao, MD (2) · Pam Taub, MD (2) · Peter Novak, MD (2) · Tae Chung, MD (2) · Christopher Grainger, MD (1) · Christopher Granger, MD (1) · Cyndya Shibao, M.D (1) · Kanecia Zimmerman, MD PhD (1) · Michael Runold, MD, PhD (1) · Richard Whitley, MD (1)