4 completed, 4 recruiting, 2 active not recruiting, 1 enrolling by invitation. 7 Not applicable, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Active not recruiting 2, Recruiting 2, Completed 1, Enrolling by invitation 1, Unknown 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Logopenic Progressive Aphasia: new trials by email Literature Review of Logopenic Progressive Aphasia trials Research Report on Logopenic Progressive Aphasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia Active tDCS + Language Therapy, Sham tDCS + Language Therapy - Primary Progressive Aphasia, Logopenic Progressive Aphasia | Phase 2 | Recruiting | Johns Hopkins University | 180 | 2024-02-13 | 2026-05-05 |
| Primary Progressive Aphasia Multicomponent Language Treatment Study Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT) - Primary Progressive Aphasia, Semantic Dementia | Not applicable | Enrolling by invitation | University of Texas at Austin | 21 | 2023-05-02 | 2025-10-08 |
| Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease Active rTMS, Sham rTMS - Alzheimer Disease, Mild Cognitive Impairment | Early Phase 1 | Recruiting | Massachusetts General Hospital | 30 | 2023-05-01 | 2026-05-06 |
| Home-Based Exercise in Primary Progressive Aphasia (HEPPA) Home-based multicomponent exercise intervention program - Primary Progressive Aphasia, Neurodegenerative Diseases | Not applicable | Completed | Montreal Heart Institute | 13 | 2023-04-05 | 2025-02-06 |
| Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment - Logopenic Progressive Aphasia, Primary Progressive Aphasia | Not applicable | Recruiting | Johns Hopkins University | 60 | 2022-10-15 | 2026-09-09 |
| Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease Active, in-person HD-tDCS or active remote tDCS, Sham, Word List Learning Intervention (WordLLI) - Alzheimer Disease, Early Onset, Atypical Alzheimer's Disease | Not applicable | Active not recruiting | Johns Hopkins University | 90 | 2020-08-17 | 2026-07-15 |
| Can Magnetic Brain Stimulation Improve Language Function in Primary Progressive Aphasia MagStim Rapid2 Transcranial Magnetic Simulation - Logopenic Progressive Aphasia | Not applicable | Unknown | University of Manitoba | 10 | 2020-06-01 | 2021-03-22 |
| Treatment for Speech and Language in Primary Progressive Aphasia Lexical Retrieval Training (LRT), Video-Implemented Script Training for Aphasia (VISTA) - Primary Progressive Aphasia, Semantic Dementia | Not applicable | Active not recruiting | University of Texas at Austin | 60 | 2017-07-01 | 2025-11-13 |
| Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks Alzheimer Disease, Early Onset, Alzheimer Disease | Completed | University of California, Los Angeles | 180 | 2016-04-04 | 2025-04-30 | |
| Tau Imaging in Young Onset Dementia [18F]-T807 imaging tracer - Alzheimer's Disease, Early Onset, Logopenic Progressive Aphasia | Completed | University of Pennsylvania | 16 | 2014-11-01 | 2020-03-25 | |
| Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's Disease Alzheimer's Disease, Posterior Cortical Atrophy | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 60 | 2009-03-01 | 2025-10-07 |
Aphasia, Primary Progressive (8) · Alzheimer Disease (5) · Frontotemporal Dementia (4) · Primary Progressive Nonfluent Aphasia (4) · Aphasia (3) · Neurodegenerative Diseases (3) · Cognitive Dysfunction (2) · Memory Disorders (2) · Amyloidosis (1) · Aphasia, Broca (1) · Apraxia, Ideomotor (1) · Apraxias (1) · Corticobasal Degeneration (1) · Dementia (1) · Language (1)
Brain Diseases (12) · Central Nervous System Diseases (12) · Mental Disorders (12) · Nervous System Diseases (12) · Neurocognitive Disorders (12) · Dementia (11) · Communication Disorders (8) · Language Disorders (8) · Neurobehavioral Manifestations (8) · Neurologic Manifestations (8) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Speech Disorders (8) · Neurodegenerative Diseases (7) · Metabolic Diseases (6)
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Language Therapy (1) · Therapeutics (1)
Johns Hopkins University (3) · University of Texas at Austin (2) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Massachusetts General Hospital (1) · Maya Henry (1) · Montreal Heart Institute (1) · University of California, Los Angeles (1) · University of Manitoba (1) · University of Pennsylvania (1)
United States (9) · Canada (3) · France (1)
Maya L Henry, PhD (3) · Kyrana Tsapkini, PhD (2) · Bruno Dubois, professor doctor (1) · David Wolk, MD (1) · Kyrana Tsapkini, PhD. (1) · Louis Bherer (1) · Mandana Modirrousta, MD PhD (1) · Mario F Mendez, MD, PhD (1) · Michelle Tsang, MD (1) · Stephanie M Grasso, PhD (1)
PMID 21705422, PMID 22099855, PMID 22710357
1RF1AG050967-01A1 (1), R01AG068881 (1), R01AG075111 (1), R01AG075404 (1), R01DC016291 (1), R56DC016291 (1)