14 completed, 4 unknown, 2 active not recruiting, 2 withdrawn. 14 Phase 2, 5 Phase 3, 3 Not applicable, 2 Phase 1, 1 Early Phase 1.
Follow Tocotrienols: new trials by email Literature Review of Tocotrienols trials Research Report on Tocotrienols
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Tocovid Suprabio 200mg in Non-alcoholic Fatty Liver (NAFL) Tocotrienols / Vitamin E, Placebo control - Hepatic Steatosis, NAFLD | Phase 2 | Completed | Yuen Kah Hay | 170 | 2021-01-01 | 2024-05-10 |
| Efficacy and Safety of Tocotrienols in CADASIL HOV-12020 (Palm tocotrienols complex), Placebo - Cadasil | Phase 2 | Completed | Hovid Berhad | 50 | 2020-12-21 | 2026-02-02 |
| Tocotrienol and Bevacizumab in Metastatic Colorectal Cancer Fluorouracil, Calcium folinate, Oxaliplatin - Colorectal Cancer Metastatic | Phase 2 | Active not recruiting | Vejle Hospital | 83 | 2020-06-26 | 2026-04-03 |
| Tocotrienol Against the Progression of End Stage Liver Disease Tocotrienol (TCT), Placebo - End Stage Liver Disease, NASH - Nonalcoholic Steatohepatitis | Phase 2 | Completed | Chandan Sen | 110 | 2019-11-01 | 2026-09-08 |
| Bevacizumab and Tocotrienol in Recurrent Ovarian Cancer Bevacizumab, Tocotrienol - Ovarian Cancer Recurrent | Phase 2 | Completed | Vejle Hospital | 20 | 2019-10-29 | 2025-01-03 |
| The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS) Tocotrienols, Placebo - Amyotrophic Lateral Sclerosis | Phase 2 | Unknown | University of Malaya | 20 | 2019-06-17 | 2019-10-25 |
| Tocotrienols for Skeletal Muscle Health placebo softgel, DeltaGold® Tocotrienol 70% - Dynapenia, Postmenopausal Women | Phase 1 / Phase 2 | Withdrawn | Texas Tech University Health Sciences Center | 2019-04-15 | 2022-02-18 | |
| Tocotrienols for Obesity of Postmenopausal Women placebo softgel, DeltaGold® Tocotrienol 70% - Obesity, Postmenopausal Women | Phase 1 / Phase 2 | Active not recruiting | Texas Tech University Health Sciences Center | 60 | 2019-03-15 | 2026-10-02 |
| Safety and Efficacy of Tocotrienols in Post-CABG Atrial Fibrillation Tocotrienols, Placebo oral capsule - Atrial Fibrillation | Phase 2 / Phase 3 | Completed | Monash University Malaysia | 250 | 2018-12-17 | 2022-08-25 |
| Tocotrienol in Combination With Neoadjuvant Chemotherapy for Women With Breast Cancer Epirubicin 90 mg/m2 iv, Cyclophosphamide 600 mg/m2 iv, Docetaxel 100 mg/m2 iv OR paclitaxel 80 mg/m2 iv - Breast Cancer | Phase 2 | Completed | Vejle Hospital | 80 | 2016-09-14 | 2021-05-20 |
| Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal Cancer Irinotecan 165 mg/m2 iv, Oxaliplatin 85 mg/m2 iv, Calcium folinate 200 mg/m2 iv - Colorectal Cancer | Phase 2 | Completed | Vejle Hospital | 70 | 2016-05-06 | 2024-08-29 |
| Preoperative Use of Tocotrienol From Annatto Bixa Orellana L. in Breast Cancer Patients: a Prospective Clinical Trial. Tocotrienol - Breast Cancer | Phase 2 | Completed | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 50 | 2016-02-09 | 2020-08-03 |
| Tocotrienol as a Nutritional Supplement in Patients With Advanced Lung Cancer Day 1: Cisplatin 75 mg/m2, Day 1: Vinorelbine 25 mg/m2, Day 8: Capsule vinorelbine 50 mg/m2 - Lung Cancer | Phase 3 | Terminated | Vejle Hospital | 79 | 2016-01-01 | 2021-05-03 |
| Stroke and Tocotrienol: Unique Role in Neuroprotection Tocotrienol, Placebo capsules - Ischemic Stroke | Phase 3 | Unknown | Seberang Jaya Clinical Research Centre | 150 | 2015-07-01 | 2018-02-13 |
| Effects of a Supplement Derived From Palm Oil on Cholesterol Levels and Chinese Red Yeast Rice in the Blood Sugar Pill, Chinese Red Yeast Rice (CRYR), CRYR + TRF - Cholesterol Lowering | Phase 2 / Phase 3 | Withdrawn | University of California, Los Angeles | 2013-10-30 | 2019-01-11 | |
| Nutrition Blood Outcomes Following Tocotrienol N2B Tocotrienol Capsules, Placebo Vehicle - Stroke | Completed | Ohio State University | 300 | 2013-03-01 | 2021-09-20 | |
| Efficacy Of Tocotrienol a Natural Vitamin E In Biopsy Wound Topical Tocotrienol (TCT), Oral Tocotrienol Capsules (TCT), Tamoxifen Cream - Scar | Unknown | Chandan K Sen | 101 | 2012-01-01 | 2018-01-29 | |
| Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF) ECGC, Tocotrienol, EGCG + Tocotrienol - Cystic Fibrosis | Not applicable | Completed | Hadassah Medical Organization | 7 | 2011-11-01 | 2017-11-30 |
| Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus Tocotrienol, Placebo - Diabetic Neuropathy, Cognitive Impairment | Phase 3 | Completed | Universiti Sains Malaysia | 300 | 2011-06-01 | 2017-05-04 |
| Study of Tocotrienol Absorption and Distribution Under Different Fat Status Tocotrienol - Absorption | Not applicable | Completed | Malaysia Palm Oil Board | 10 | 2009-09-01 | 2010-08-20 |
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Stroke (3) · Breast Neoplasms (2) · Cerebrovascular Disorders (2) · Cognitive Dysfunction (2) · Colorectal Neoplasms (2) · End Stage Liver Disease (2) · Fatty Liver (2) · Non-alcoholic Fatty Liver Disease (2) · Amyotrophic Lateral Sclerosis (1) · Atrial Fibrillation (1) · CADASIL (1) · Carotid Stenosis (1) · Cerebral Small Vessel Diseases (1) · Cicatrix (1) · Cystic Fibrosis (1)
Vejle Hospital (5) · Chandan K Sen (2) · Texas Tech University Health Sciences Center (2) · Universiti Sains Malaysia (2) · Chandan Sen (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Hadassah Medical Organization (1) · Hovid Berhad (1) · Malaysia Palm Oil Board (1) · Mid-Atlantic Retina Consultations, Inc. (1) · Monash University Malaysia (1) · Ohio State University (1) · Seberang Jaya Clinical Research Centre (1) · University of California, Los Angeles (1) · University of Malaya (1)
United States (8) · Malaysia (7) · Denmark (5) · France (1) · Israel (1) · Italy (1)
Chwan-Li Shen, PhD (2) · Kah Hay Yuen, PhD (2) · Ahmad Farouk Musa, MD (1) · Chandan K Sen, Ph.D (1) · Chandan K Sen, PhD (1) · Chandan Sen, PhD (1) · Christa H Nyhus, MD (1) · Cristina Ferraris, MD (1) · David Ho (1) · Eitan Kerem, MD (1) · Erik H Jakobsen, MD (1) · Lars H Jensen, PhD (1) · Louise R Larsen, MD (1)
PMID 10227040, PMID 10574414, PMID 10964265, PMID 11160563, PMID 11206194, PMID 11516635, PMID 11882333, PMID 11893482, PMID 11999415, PMID 12881019, PMID 1433170, PMID 14566071, PMID 14698044, PMID 14747214, PMID 15035006, PMID 15203383, PMID 15498784, PMID 15569611, PMID 15723336, PMID 15746970, PMID 15753141, PMID 15792944, PMID 15823271, PMID 16008108, PMID 16159610, PMID 16249550, PMID 16275870, PMID 16450399, PMID 16458936, PMID 16645729, PMID 16831864, PMID 17109639, PMID 18081943, PMID 18452640, PMID 18490840, PMID 18599020, PMID 18806966, PMID 19035289, PMID 19066370, PMID 19071006, PMID 19121919, PMID 19142032, PMID 19346993, PMID 19491296, PMID 19702331, PMID 19732602, PMID 2012015, PMID 20188744, PMID 20306477, PMID 20493172
2014 (1)