18 completed. 18 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 18 |
| Phase 2 | 4 | Completed 4 |
Follow Liposarcoma: new trials by email Literature Review of Liposarcoma trials Research Report on Liposarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas DCC-3014, Avelumab - Sarcoma, Advanced Sarcoma | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 32 | 2020-01-22 | 2025-08-28 |
| Modified T Cells, Chemotherapy, and Aldesleukin With or Without LV305 and CMB305 in Treating Participants With Advanced or Recurrent Sarcoma Aldesleukin, Autologous NY-ESO-1-specific CD8-positive T Lymphocytes, Cyclophosphamide - HLA-A*0201 Positive Cells Present, NY-ESO-1 Positive Tumor Cells Present | Phase 1 | Completed | M.D. Anderson Cancer Center | 15 | 2018-09-13 | 2023-10-16 |
| Lenvatinib and Eribulin in Advanced Soft Tissue Sarcoma Eribulin, Lenvatinib - Leiomyosarcoma, Liposarcoma | Phase 1 / Phase 2 | Completed | National Taiwan University Hospital | 30 | 2018-07-12 | 2025-12-05 |
| Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Doxorubicin Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study - Advanced Soft Tissue Sarcoma, Locally Advanced Angiosarcoma | Phase 1 | Completed | OHSU Knight Cancer Institute | 16 | 2017-03-10 | 2023-08-16 |
| Study of Safety and Efficacy of HDM201 in Combination With LEE011 in Patients With Liposarcoma HDM201, LEE011 - Liposarcoma | Phase 1 | Completed | Novartis Pharmaceuticals | 74 | 2015-03-13 | 2020-12-09 |
| A Trial of Oral 5-azacitidine in Combination With Romidepsin in Advanced Solid Tumors, With an Expansion Cohort in Virally Mediated Cancers and Liposarcoma oral 5-azacitidine in combination with romidepsin - Solid Tumors, Virally Mediated Cancers and Liposarcoma | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 18 | 2012-02-01 | 2017-03-24 |
| Autologous T Cells and Cyclophosphamide in Treating Patients With Soft Tissue Sarcoma That is Metastatic or Cannot Be Removed By Surgery cyclophosphamide, NY-ESO-1-specific T cells, laboratory biomarker analysis - Adult Liposarcoma, Adult Synovial Sarcoma | Phase 1 | Completed | Fred Hutchinson Cancer Center | 6 | 2012-01-01 | 2014-12-11 |
| Combination Therapy of Gemcitabine and Trabectedin in L-sarcomas Gemcitabine + Trabectedin - Leiomyosarcoma, Liposarcoma | Phase 1 | Completed | Heidelberg University | 5 | 2011-11-01 | 2014-12-16 |
| Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Gamma-Secretase Inhibitor RO4929097, Laboratory Biomarker Analysis, Pharmacological Study - Adult Alveolar Soft Part Sarcoma, Adult Angiosarcoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 78 | 2010-06-01 | 2018-08-15 |
| Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma temsirolimus plus liposomal doxorubicin - Sarcoma | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 24 | 2009-09-01 | 2019-03-11 |
| Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Cixutumumab, Doxorubicin Hydrochloride, Laboratory Biomarker Analysis - Adult Angiosarcoma, Adult Desmoplastic Small Round Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2008-06-01 | 2016-05-17 |
| Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma oral belinostat - Solid Tumor, Lymphoma | Phase 1 | Completed | Valerio Therapeutics | 121 | 2006-06-01 | 2015-07-08 |
| Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors belinostat, 5-Fluorouracil (5-FU) - Tumor | Phase 1 | Completed | Valerio Therapeutics | 35 | 2005-09-01 | 2015-07-08 |
| Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery celecoxib, adjuvant therapy, radiation therapy - Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma | Phase 1 | Completed | University of Miami | 3 | 2004-03-01 | 2016-12-15 |
| Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma ifosfamide, pegylated liposomal doxorubicin hydrochloride - Sarcoma | Phase 1 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 28 | 2001-11-01 | 2012-09-24 |
| Vaccine Therapy and Sargramostim in Treating Patients With Sarcoma or Brain Tumor sargramostim, telomerase: 540-548 peptide vaccine - Brain and Central Nervous System Tumors, Gastrointestinal Stromal Tumor | Phase 1 | Completed | Dana-Farber Cancer Institute | 2000-12-01 | 2010-12-28 | |
| STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma imatinib mesylate - Endometrial Cancer, Gastrointestinal Stromal Tumor | Phase 1 / Phase 2 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 91 | 2000-08-01 | 2012-09-24 |
| Radiation Therapy Plus Doxorubicin in Treating Patients With Resectable Primary or Recurrent Retroperitoneal Soft Tissue Sarcoma Doxorubicin hydrochloride (DOX), Conventional surgery, Intraoperative radiation therapy (IORT) - Sarcoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 36 | 1997-07-01 | 2012-07-30 |
Sarcoma (14) · Leiomyosarcoma (13) · Sarcoma, Synovial (10) · Histiocytoma, Malignant Fibrous (9) · Fibrosarcoma (8) · Hemangiosarcoma (8) · Neurofibrosarcoma (7) · Chondrosarcoma (5) · Rhabdomyosarcoma (5) · Dermatofibrosarcoma (4) · Hemangiopericytoma, Malignant (4) · Malignant mesenchymal tumor (4) · Osteosarcoma (4) · Gastrointestinal Stromal Tumors (3)
Neoplasms by Histologic Type (18) · Neoplasms, Adipose Tissue (18) · Neoplasms, Connective and Soft Tissue (18) · Neoplasms (17) · Neoplasms, Connective Tissue (13) · Neoplasms, Muscle Tissue (13) · Neoplasms, Fibrous Tissue (10) · Histiocytoma (9) · Neoplasms, Nerve Tissue (8) · Neoplasms, Vascular Tissue (8) · Nervous System Diseases (8) · Nervous System Neoplasms (8) · Nerve Sheath Neoplasms (7) · Neurofibroma (7) · Neuromuscular Diseases (7)
Doxorubicin (3) · Cyclophosphamide (2) · Radiotherapy (2) · belinostat (2) · ribociclib (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Azacitidine (1) · Celecoxib (1) · Chemotherapy, Adjuvant (1) · Fluorouracil (1) · Gemcitabine (1) · HhAntag691 (1) · Ifosfamide (1) · Imatinib Mesylate (1) · Trabectedin (1)
European Organisation for Research and Treatment of Cancer - EORTC (2) · M.D. Anderson Cancer Center (2) · National Cancer Institute (NCI) (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Valerio Therapeutics (2) · Dana-Farber Cancer Institute (1) · Fred Hutchinson Cancer Center (1) · Heidelberg University (1) · Memorial Sloan Kettering Cancer Center (1) · National Taiwan University Hospital (1) · Novartis Pharmaceuticals (1) · OHSU Knight Cancer Institute (1) · University of Miami (1)
United States (13) · Denmark (3) · Germany (3) · France (2) · Taiwan (2) · United Kingdom (2) · Belgium (1) · Canada (1) · Netherlands (1) · Singapore (1) · Spain (1)
Aaron H. Wolfson, MD (1) · Bernd Kasper, MD, PhD (1) · David M Loeb, MD, PhD (1) · Jacob Verweij, MD, PhD (1) · Lara E Davis (1) · Mrinal Gounder (1) · Neeta Somaiah (1) · Nilofer Azad, MD (1) · Ole S. Nielsen, MD (1) · Peter W. Pisters, MD (1) · Rashmi Chugh (1) · Sandra D'Angelo, MD (1) · Seth Pollack (1)
PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15592836, PMID 19088049, PMID 23382028, PMID 25591040, PMID 25858498, PMID 30410720, PMID 31012962, PMID 36129471
N01CM00071 (1), N01CM62206 (1), P30CA006516 (1), P30CA008748 (1), P30CA014599 (1), P30CA015704 (1), P30CA016672 (1), U01CA069856 (1)