18 completed, 17 recruiting, 9 terminated, 6 active not recruiting. 60 Phase 1, 19 Phase 2.
Follow Liposarcoma: new trials by email Literature Review of Liposarcoma trials Research Report on Liposarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Hepatocellular Carcinoma | Phase 1 | Not yet recruiting | Seattle Children's Hospital | 21 | 2026-04-01 | 2025-11-04 |
| Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma Abemaciclib, Biopsy Procedure, Biospecimen Collection - Advanced Dedifferentiated Liposarcoma, Advanced Leiomyosarcoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 74 | 2026-03-18 | 2026-10-21 |
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma Lymphodepletion, TCR-T cells (MDG1015) - Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer | Phase 1 | Not yet recruiting | Medigene AG | 55 | 2025-07-01 | 2024-12-27 |
| Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors SA53-OS (phase 1), SA53-OS (phase 2) - Solid Tumor | Phase 1 / Phase 2 | Recruiting | Lamassu Bio Inc | 55 | 2025-06-16 | 2026-11-09 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas STC-15 in combination with toripalimab, STC-15 monotherapy - Solid Tumor, Sarcoma | Phase 1 / Phase 2 | Recruiting | STORM Therapeutics LTD | 107 | 2025-05-05 | 2026-10-22 |
| A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas Abemaciclib, Computed Tomography, Magnetic Resonance Imaging - Retroperitoneal Sarcoma, Liposarcoma | Phase 1 | Recruiting | University of Washington | 18 | 2025-03-19 | 2026-09-17 |
| A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma Mirdametinib, Palbociclib - Well Differentiated Liposarcoma, Dedifferentiated Liposarcoma | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 54 | 2025-02-19 | 2026-09-16 |
| A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors OKN4395, Pembrolizumab, Fasting - Solid Tumours, Sarcoma | Phase 1 | Recruiting | Epkin | 146 | 2025-01-23 | 2026-06-11 |
| First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors DS-2243a - Solid Tumors, Sarcoma | Phase 1 | Recruiting | Daiichi Sankyo | 150 | 2024-11-14 | 2026-09-04 |
| Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors Silmitasertib, Irinotecan, Temozolomide - Neuroblastoma, Ewing Sarcoma | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 104 | 2024-10-30 | 2026-11-12 |
| BTX-A51 in Patients With Liposarcoma or CIC-rearranged Sarcoma BTX-A51 - Liposarcoma, Recurrent Liposarcoma | Phase 1 | Active not recruiting | Michael Wagner, MD | 24 | 2024-09-30 | 2026-07-01 |
| Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors CARE T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Recruiting | Baylor College of Medicine | 24 | 2024-05-24 | 2026-08-06 |
| NM32-2668 in Adult Patients With Selected Advanced Solid Tumors NM32-2668 - Ovarian Carcinoma, Fallopian Tube Carcinoma | Phase 1 | Terminated | Numab Therapeutics AG | 11 | 2024-05-01 | 2025-07-23 |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
| Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1 Fludarabine phosphate, NY-ESO-1 TCR/IL-15 NK, Cyclophosphamide - Synovial Sarcoma, Myxoid/Round Cell Liposarcoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 44 | 2024-03-27 | 2026-07-29 |
| Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Dedifferentiated Liposarcoma, Metastatic Leiomyosarcoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 30 | 2024-02-06 | 2026-11-04 |
| Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors. PF-07224826, Fulvestrant - Breast Cancer, Ovarian Cancer | Phase 1 | Withdrawn | Pfizer | 2024-01-15 | 2023-11-08 | |
| START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer PeptiCRAd-1, Cyclophosphamide, Pembrolizumab - Melanoma (Skin), Triple-Negative Breast Cancer | Phase 1 | Recruiting | Valo Therapeutics Oy | 15 | 2023-02-02 | 2026-11-09 |
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Sarcoma (31) · Leiomyosarcoma (25) · Sarcoma, Synovial (22) · Liposarcoma, Myxoid (19) · Histiocytoma, Malignant Fibrous (13) · Rhabdomyosarcoma (13) · Fibrosarcoma (10) · Neurofibrosarcoma (10) · Hemangiosarcoma (9) · Carcinoma, Non-Small-Cell Lung (8) · Chondrosarcoma (8) · Dermatofibrosarcoma (7) · Osteosarcoma (7) · Endodermal Sinus Tumor (6)
Neoplasms by Histologic Type (60) · Neoplasms, Adipose Tissue (59) · Neoplasms, Connective and Soft Tissue (59) · Neoplasms (54) · Neoplasms, Muscle Tissue (33) · Neoplasms, Connective Tissue (31) · Sarcoma (29) · Neoplasms by Site (21) · Neoplasms, Nerve Tissue (18) · Neoplasms, Fibrous Tissue (17) · Digestive System Diseases (15) · Digestive System Neoplasms (15) · Female Urogenital Diseases (15) · Female Urogenital Diseases and Pregnancy Complications (15)
Cyclophosphamide (11) · Doxorubicin (6) · fludarabine (5) · Radiotherapy (4) · Biopsy (3) · Trabectedin (3) · Docetaxel (2) · Gemcitabine (2) · Ifosfamide (2) · Magnetic Resonance Spectroscopy (2) · Radiation (2) · Specimen Handling (2) · Topotecan (2) · abemaciclib (2) · avelumab (2)
Baylor College of Medicine (4) · Fred Hutchinson Cancer Center (4) · National Cancer Institute (NCI) (4) · Adaptimmune (3) · M.D. Anderson Cancer Center (3) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Memorial Sloan Kettering Cancer Center (2) · OHSU Knight Cancer Institute (2) · Salarius Pharmaceuticals, LLC (2) · Seattle Children's Hospital (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Valerio Therapeutics (2) · Ascentage Pharma Group Inc. (1) · Broto, Javier MartÃn, M.D. (1) · City of Hope Medical Center (1)
United States (49) · Germany (7) · Canada (6) · Netherlands (5) · Australia (4) · France (4) · United Kingdom (4) · Denmark (3) · Spain (3) · Sweden (3) · Belgium (2) · Italy (2) · Taiwan (2) · China (1) · Russia (1)
Adaptimmune Patient Enquiries (3) · David Steffin, MD (3) · Seth Pollack (3) · Lara E Davis (2) · Aaron H. Wolfson, MD (1) · Bernd Kasper, MD, PhD (1) · Candace L Haddox (1) · Chandrika Behura, MD (1) · Colleen Annesley (1) · Colleen Annesley, MD (1) · Corinne Summers (1) · Corinne Summers, MD (1) · David Dr. Zhen, MD (1) · David Hong, MD (1) · David M Loeb, MD, PhD (1)
PMID 32827353, PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15592836, PMID 19088049, PMID 23382028, PMID 25591040, PMID 25858498, PMID 30410720, PMID 31012962, PMID 31143880, PMID 31215818, PMID 32002290, PMID 32029687, PMID 32077895, PMID 35507536, PMID 36129471, PMID 36624315, PMID 37794590, PMID 42501677
P30CA015704 (3), 2019 (2), K23CA175167 (1), N01CM00071 (1), N01CM62206 (1), P30CA006516 (1), P30CA008748 (1), P30CA014599 (1), P30CA016672 (1), U01CA069856 (1), UM1CA186688 (1), UM1CA186709 (1)