37 completed, 30 unknown, 13 recruiting, 6 terminated. 95 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 95 | Completed 37, Unknown 30, Recruiting 13, Terminated 6, Not yet recruiting 4, Enrolling by invitation 3, Active not recruiting 1, Withdrawn 1 |
Follow Lip Diseases: new trials by email Literature Review of Lip Diseases trials Research Report on Lip Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair Palatal Nerve Block, Suprazygomatic Maxillary Nerve Block - Cleft Lip, Cleft Palate +/- Lip | Not applicable | Not yet recruiting | Children's National Research Institute | 144 | 2026-12-16 | 2026-10-23 |
| Speech Intervention Frameworks in Cantonese-speaking Children and Adolescences With Cleft Palate +/- Lip Non-linear based phonological speech intervention, Linear-based speech intervention - Cleft Palate +/- Lip | Not applicable | Enrolling by invitation | Chinese University of Hong Kong | 12 | 2026-07-24 | 2026-07-09 |
| MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair Modified Furlow Palatoplasty combined with buccinator myomucosal flap - Cleft Palate, Cleft Palate, Unilateral, Complete | Not applicable | Not yet recruiting | Cairo University | 10 | 2026-06-01 | 2026-04-07 |
| Effects of AlignBabyCleft (ABaCleft) Appliance. Orthodontic appliance to carry out dentoalveolar movement - Cleft Lip, Cleft Palate | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 30 | 2025-11-21 | 2025-04-25 |
| Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation. Early intervention for language, articulation and palatal function skills - Cleft Lip and Cleft Palate, Cleft Lip Palate | Not applicable | Not yet recruiting | Old Dominion University | 200 | 2025-10-21 | 2025-10-22 |
| Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery ketamine, Nalbuphine, Dexmedetomidine - Orofacial Clefts, Cleft Lip and Palate | Not applicable | Recruiting | University Medical Centre Ljubljana | 60 | 2025-09-01 | 2026-01-14 |
| Indications and Evaluation of Microfat Grafting in Cleft Lip Nasal Deformities Microfat grafting - Cleft Lip and Nose | Not applicable | Unknown | Assiut University | 30 | 2025-05-01 | 2024-06-18 |
| Evaluation of Maxillary Expansion Using Clear Aligners' Therapy in Patients With Cleft Lip and Palate at the Mixed Dentition Stage clear aligners - Maxillary Deficiency, Cleft Lip and Palate | Not applicable | Recruiting | Cairo University | 10 | 2025-04-06 | 2025-06-12 |
| Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy. Modified Millard rotation advancement flap technique, botulinum toxin injection (BTX A) before surgical intervention - Unilateral Cleft Lip | Not applicable | Completed | Mansoura University | 32 | 2025-03-15 | 2026-07-22 |
| Efficacy of 3D-Printed Mouth Splints Splint - Microstomia | Not applicable | Recruiting | Wake Forest University Health Sciences | 10 | 2025-02-21 | 2025-12-17 |
| Improving the Outcomes of Nasoalveolar Molding in Complete Bilateral Cleft Lip and Palate Neonates Using a Modification in the Design of the Conventional Molding Appliance. vomer molding appliance, conventional molding appliance - Cleft Lip and Cleft Palate, Cleft Lip Bilateral | Not applicable | Completed | Tanta University | 20 | 2024-12-01 | 2026-09-11 |
| Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Palate High intensive combined phonetic-phonological intervention, Low intensive combined phonetic-phonological intervention - Cleft Palate Children, Speech Therapy | Not applicable | Recruiting | University Ghent | 70 | 2024-11-26 | 2025-01-13 |
| The Effectiveness of Adhesive Versus Conventional Nasoalveolar Molding on Children With Unilateral Cleft Lip and Palate Nasoalveolar molding in unilateral cleft lip and palate - Cleft Lip and Palate | Not applicable | Unknown | Al-Azhar University | 30 | 2024-07-20 | 2024-06-11 |
| Single Stage Versus Multiple Staged Repair of Nasal & Alveolar Deformities in Patients With Cleft Lip and Palate Rhinoplasty with or without cleft alveolus repair - Cleft Lip and Palate, Rhinoplasty | Not applicable | Recruiting | Assiut University | 40 | 2024-07-20 | 2024-07-19 |
| Evaluation of Efficiency the Full Digital Nasoalveolar Molding (F-D-NAM) on Nose and Lip Esthetics and Maxillary Arch Changes in Infants With Cleft Lip and Palate F-D-NAM - Cleft Lip and Palate | Not applicable | Completed | Cairo University | 14 | 2024-06-01 | 2026-06-22 |
| Effect of Different Nasal Stent Designs With Nasoalveolar Molding Appliance Grape Design Nasal Stent - Cleft Lip, Cleft Lip and Palate | Not applicable | Unknown | Cairo University | 28 | 2024-05-15 | 2024-05-13 |
| Book Sharing for Toddlers With Clefts Book-Sharing for Toddlers with Clefts (BOOST) - Cleft Palate, Cleft Lip and Palate | Not applicable | Enrolling by invitation | Seattle Children's Hospital | 320 | 2024-05-01 | 2025-05-23 |
| Patient Specific Implant Versus Miniplates for Advancement of Hypoplastic Maxilla PSI, Conventional miniplates - Cleft Lip and Palate | Not applicable | Unknown | Cairo University | 20 | 2024-05-01 | 2024-04-19 |
| Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral Surgery Toothbrush - Toothbrushing, Gingivitis | Not applicable | Recruiting | Children's Hospital Los Angeles | 198 | 2024-03-11 | 2024-05-13 |
| Effectiveness of a Customized 3D Printed Nostril Retainer Combined With Taping Vs.Taping Only on Enhancing the Nasolabial Esthetics and Maxillary Arch Dimensions in Infants With Unilateral Complete Cleft Lip and Palate. Customized 3D printed nostril retainer combined with lip taping, Lip taping - Cleft Lip and Palate | Not applicable | Unknown | Cairo University | 30 | 2024-01-30 | 2024-01-18 |
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Cleft Lip (77) · Cleft Palate (16) · Herpes Labialis (10) · Carcinoma, Basal Cell (6) · Carcinoma, Squamous Cell (6) · Lip Neoplasms (6) · Skin Neoplasms (6) · Sarcoma, Kaposi (5) · Soft Tissue Neoplasms (5) · Squamous Cell Carcinoma of Head and Neck (5) · Tongue Neoplasms (5) · Herpes Simplex (3) · Cheilitis (2) · Cicatrix (2) · Communication Disorders (2)
Mouth Diseases (95) · Stomatognathic Diseases (95) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (77) · Mouth Abnormalities (77) · Stomatognathic System Abnormalities (77) · Congenital Abnormalities (75) · Musculoskeletal Abnormalities (19) · Musculoskeletal Diseases (19) · Skin and Connective Tissue Diseases (19) · Craniofacial Abnormalities (17) · Jaw Abnormalities (17) · Jaw Diseases (17) · Skin Diseases (17) · Infections (16)
Nasoalveolar Molding (3) · Prebiotics (2) · Probiotics (2) · Allantoin (1) · Alveolar Bone Grafting (1) · Bite Force (1) · Botulinum Toxins (1) · Botulinum Toxins, Type A (1) · Dexmedetomidine (1) · Early Intervention, Educational (1) · Head Movements (1) · Ketamine (1) · Nalbuphine (1) · Ointments (1) · Orthodontics (1)
Cairo University (17) · Alpha Tau Medical LTD. (6) · Assistance Publique - Hôpitaux de Paris (3) · Faculty of Dental Medicine for Girls (3) · Al-Azhar University (2) · Alexandria University (2) · Assiut University (2) · Brno University Hospital (2) · Chang Gung Memorial Hospital (2) · Chinese University of Hong Kong (2) · Oslo University Hospital (2) · Sprim Advanced Life Sciences (2) · The University of Texas Health Science Center, Houston (2) · University Ghent (2) · University of Baghdad (2)
Egypt (25) · United States (10) · France (7) · United Kingdom (5) · Brazil (4) · Israel (4) · Germany (3) · Belgium (2) · Czechia (2) · Hong Kong (2) · Iraq (2) · Netherlands (2) · Norway (2) · Turkey (Türkiye) (2) · Canada (1)
Adel F Hassan, Phd (1) · Ahmed M Ali, lecturer (1) · Amany M. Diab, PhD (1) · Aron Popovtzer (1) · Aron Popovtzer, M.D (1) · Basel Saeed Shamaa, Master's (1) · Brent Collett, PhD (1) · Brett T Chiquet, DDS (1) · Carroll Ann Trotman (1) · Chelsea Wehr, DDS (1) · Choco Ho Yin Ho, PhD Candidate (1) · Christopher Runyan, MD, PhD (1)
PMID 40981509, PMID 14707617, PMID 1472517, PMID 15988248, PMID 16563165, PMID 18452361, PMID 19382840, PMID 21328261, PMID 21823827, PMID 21948638, PMID 22204448, PMID 24705041, PMID 25206201, PMID 25770054, PMID 26997574, PMID 27002917, PMID 27563610, PMID 28921849, PMID 29428487, PMID 29868164, PMID 31795731, PMID 31860800, PMID 32049908, PMID 32081579, PMID 32195950, PMID 32256610, PMID 33107321, PMID 34982018, PMID 35973113, PMID 36126199, PMID 36601286, PMID 36652281, PMID 37981415, PMID 40013415, PMID 40485092, PMID 40830787, PMID 41566030, PMID 8547288
2014 (1), U01HD040561 (1)