31 completed, 6 recruiting, 5 unknown, 3 terminated. 51 Phase 2, 4 Phase 1, 3 Phase 3.
Follow Lichen Planus: new trials by email Literature Review of Lichen Planus trials Research Report on Lichen Planus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Efficacy and Safety of GIA632 Across a Range of Doses in Participants With Moderate to Severe Cutaneous Lichen Planus Placebo, GIA632 - Cutaneous Lichen Planus | Phase 2 | Recruiting | Novartis Pharmaceuticals | 259 | 2026-09-29 | 2026-10-13 |
| Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer | Phase 2 | Not yet recruiting | University of Massachusetts, Boston | 65 | 2026-09-01 | 2026-03-19 |
| Safety and Biomarker Responses of Delgocitinib (JAK1,2,3/TYK2 Inhibitor) in Central Centrifugal Cicatricial Alopecia and Lichen Planopilaris Delgocitinib - Central Centrifugal Cicatricial Alopecia, Lichen Planopilaris | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 30 | 2026-05-19 | 2026-07-10 |
| A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris Oral Brepocitinib, Placebo - Lichen Planopilaris | Phase 2 / Phase 3 | Recruiting | Priovant Therapeutics, Inc. | 342 | 2026-03-19 | 2026-07-08 |
| Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus Topical Bromelain, 0.1% topical triamcinolone acetonide, Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase - Oral Lichen Planus | Phase 2 | Recruiting | Cairo University | 42 | 2026-02-18 | 2026-06-09 |
| Systemic Treatment Options for Generalized Lichen Planus Methotrexate (drug), Acitretin - Lichen Planus | Phase 2 | Not yet recruiting | Sheikh Zayed Medical College | 124 | 2024-12-10 | 2024-12-18 |
| Thyme Honey for Management of Oral Lichen Planus thyme honey, Triamcinolone Acetonide - Oral Lichen Planus | Phase 1 / Phase 2 | Enrolling by invitation | British University In Egypt | 30 | 2024-10-12 | 2025-02-06 |
| Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus Clobetasol Patch, Clobetasol + Resveratrol Patch, Clobetasol in Orabase - Oral Lichen Planus, Oral Lichen Planus Related Stress | Phase 2 | Recruiting | University of Palermo | 45 | 2024-09-04 | 2025-08-03 |
| Evaluation of the Efficacy of 0.08% Tacrolimus Nanoencapsulated Aqueous Solution Spray Vs. 0.1% Free Tacrolimus Commercial Ointment in the Treatment of Oral Lichen Planus Tacrolimus modified-release, tacrolimus ointment 0.1% - Oral Erosive Lichen Planus | Phase 1 / Phase 2 | Recruiting | Hospital de Clinicas de Porto Alegre | 46 | 2024-09-03 | 2024-10-02 |
| Evaluating LP-10 in Subjects With OLP LP-10 (Liposomal Tacrolimus) - Oral Lichen Planus | Phase 2 | Unknown | Lipella Pharmaceuticals, Inc. | 24 | 2024-07-01 | 2025-05-15 |
| Efficacy and Safety of Baricitinib in Oral Lichen Planus: a Proof-of-Concept Study Baricitinib 4 milligram Oral Tablet - Lichen Planus, Oral, Lichen Planus, Mucosal | Phase 2 | Active not recruiting | University of North Carolina, Chapel Hill | 10 | 2024-03-13 | 2026-09-01 |
| A Study of Deucravacitinib to Treat LPP and FFA Deucravacitinib - Lichen Planopilaris | Phase 2 | Completed | Mayo Clinic | 12 | 2023-11-07 | 2025-06-08 |
| A Comparison of Photodynamic Therapy and Topical Clobetasol in Treatment of Oral Lichen Planus: a Split-Mouth Randomised Controlled Study Photodynamic Therapy, Clobetasol - Oral Lichen Planus | Phase 2 | Completed | Wroclaw Medical University | 29 | 2023-06-01 | 2024-12-30 |
| Evaluation of Efficacy of Neem (Azadirachta Indica) Versus Triamcinolone Acetonide in the Treatment of Oral Lichen Planus. Neem gel, Triamcinolone Acetonide - Oral Lichen Planus | Phase 1 / Phase 2 | Completed | Goa Dental College | 60 | 2023-02-05 | 2025-09-03 |
| Ritlecitinib for Cicatricial Alopecia PF-06651600 - Cicatricial Alopecia | Phase 2 | Completed | Emma Guttman | 50 | 2022-12-15 | 2026-07-15 |
| A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Cutaneous Lichen Planus Ruxolitinib cream, Vehicle cream - Cutaneous Lichen Planus | Phase 2 | Completed | Incyte Corporation | 64 | 2022-11-23 | 2024-10-24 |
| Baricitinib (LY3009104) in the Treatment of Cutaneous Lichen Planus Baricitinib (LY3009104) 2 mg, Baricitinib (LY3009104) 4 mg - Cutaneous Lichen Planus | Phase 2 | Completed | Aaron R. Mangold | 12 | 2022-01-11 | 2024-06-11 |
| Dexamethasone Solution and Dexamethasone in Mucolox™ dexamethasone 0.5mg/5ml solution, dexamethasone 0.5mg/5ml solution in Mucolox™ - Oral Lichen Planus, Mucous Membrane Pemphigoid | Phase 2 | Completed | University of California, San Francisco | 29 | 2020-12-26 | 2023-12-15 |
| Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus Triamcinolone Acetonide, Photodynamic Therapy - Lichen Planus, Oral | Phase 2 | Completed | Wroclaw Medical University | 30 | 2020-12-10 | 2021-08-02 |
| PoC Study to Evaluate the Efficacy and Safety of Secukinumab 300 mg in Patients With Lichen Planus secukinumab 300 mg Q4W, secukinumab 300 mg Q2W, Placebo - Lichen Planus: Cutaneous Lichen Planus, Mucosal Lichen Planus and Lichen Planopilaris | Phase 2 | Completed | Novartis Pharmaceuticals | 111 | 2020-07-27 | 2023-08-22 |
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Lichen Planus, Oral (33) · Alopecia (1) · Atrophy (1) · Autoimmune Diseases (1) · Bronchiolitis Obliterans Syndrome (1) · Carcinoma in Situ (1) · Chronic Urticaria (1) · Leukoplakia, Oral (1) · Mouth Neoplasms (1) · Neurodermatitis (1) · Oral Ulcer (1) · Pain (1) · Pemphigoid, Benign Mucous Membrane (1) · Pemphigus (1)
Lichenoid Eruptions (51) · Skin Diseases, Papulosquamous (51) · Skin and Connective Tissue Diseases (51) · Skin Diseases (50) · Mouth Diseases (33) · Stomatognathic Diseases (33) · Pathological Conditions, Signs and Symptoms (5) · Immune System Diseases (3) · Pathological Conditions, Anatomical (3) · Pathologic Processes (2) · Signs and Symptoms (2) · Autoimmune Diseases (1) · Bronchial Diseases (1) · Bronchiolitis (1)
Triamcinolone Acetonide (6) · Clobetasol (5) · Dexamethasone (3) · Photochemotherapy (3) · Adrenal Cortex Hormones (2) · Diarylheptanoids (2) · Orabase (2) · Solutions (2) · Triamcinolone (2) · apremilast (2) · baricitinib (2) · betamethasone-17,21-dipropionate (2) · 1-phenyl-3,3-dimethyltriazene (1) · Acitretin (1) · Alefacept (1)
Mashhad University of Medical Sciences (3) · Wroclaw Medical University (3) · Aaron R. Mangold (2) · Cairo University (2) · Mayo Clinic (2) · National Institute of Dental and Craniofacial Research (NIDCR) (2) · Novartis Pharmaceuticals (2) · University of California, San Francisco (2) · Brigham and Women's Hospital (1) · British University In Egypt (1) · College of Dental Sciences, India (1) · Dermtreat (1) · Emma Guttman (1) · Garlapati Komali (1) · Genentech, Inc. (1)
United States (26) · Canada (5) · Egypt (4) · India (4) · Iran (4) · Poland (3) · Australia (2) · Brazil (2) · Germany (2) · United Kingdom (2) · China (1) · Croatia (1) · Denmark (1) · France (1) · Ireland (1)
Aaron Mangold, MD (1) · Aaron R Mangold (1) · Aaron R Mangold, MD (1) · Alessandro Villa, DDS, PhD, MPH (1) · Alexandra B. Kimball, MD, MPH (1) · Arash Mansourian, DDS,MS (1) · Benjamin Ungar, MD (1) · Christopher Hull, MD (1) · Clare E Foss, MD (1) · David F Fiorentino, MD, PhD (1)
PMID 18155609, PMID 21175873, PMID 21907450, PMID 22910104, PMID 26507685, PMID 33831097, PMID 35131254, PMID 35218680, PMID 36197049, PMID 37505393, PMID 37549933, PMID 37794275, PMID 38260663, PMID 39951132, PMID 41174333, PMID 42163196, PMID 42776548
2019 (1), 2025 (1), U01CA279862 (1)