23 completed, 12 terminated, 1 withdrawn. 10 Phase 2, 8 Phase 4, 6 Not applicable, 5 Phase 1, 5 Phase 3.
Follow Alefacept: new trials by email Literature Review of Alefacept trials Research Report on Alefacept
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alefacept in Kidney Transplant Recipients Amevive - Kidney Transplantation | Not applicable | Withdrawn | University Hospitals Cleveland Medical Center | 2011-10-01 | 2012-02-22 | |
| Alefacept in Patients With Relapsed/Refractory Aplastic Anemia Alefacept - Aplastic Anemia | Phase 1 | Terminated | The Cleveland Clinic | 4 | 2011-05-01 | 2018-01-26 |
| Inducing Remission in Type 1 Diabetes With Alefacept Alefacept, Placebo - New-onset Type 1 Diabetes Mellitus | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 49 | 2011-03-01 | 2017-07-06 |
| Alefacept in Subjects With Steroid-Refractory Chronic Graft-versus-Host Disease Alefacept - Chronic Graft-versus-host Disease | Phase 2 | Terminated | Dana-Farber Cancer Institute | 6 | 2010-10-01 | 2013-08-13 |
| Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation Alefacept - Thalassemia, Sickle Cell Disease | Not applicable | Terminated | Emory University | 3 | 2010-09-01 | 2017-07-27 |
| A Pilot Study to Assess the Safety and Efficacy of Alefacept in de Novo Kidney Transplant Recipients Alefacept (ASP0485) - Transplant; Failure, Kidney | Phase 1 | Terminated | Northwestern University | 9 | 2010-07-01 | 2013-05-03 |
| Safety and Pharmacokinetics (PK) of Alefacept in Adolescent Subjects With Moderate to Severe Psoriasis alefacept - Psoriasis | Phase 2 | Completed | Astellas Pharma Inc | 30 | 2009-04-01 | 2013-12-12 |
| A Pilot Study of Alefacept for the Treatment of Pityriasis Rubra Pilaris Alefacept - Pityriasis Rubra Pilaris | Phase 4 | Terminated | Joshua Zeichner | 1 | 2008-12-01 | 2018-05-11 |
| Assess the Long-term Effectiveness and Safety of Amevive (Alefacept) in Subjects With Moderate to Severe Chronic Plaque Psoriasis Amevive exposure - Chronic Plaque Psoriasis | Terminated | Astellas Pharma Inc | 64 | 2008-07-01 | 2013-02-28 | |
| Long-Term One Year Use of Alefacept (Amevive®) in Moderate to Severe Chronic Plaque Type Psoriasis Alefacept - Psoriasis | Phase 4 | Completed | Wake Forest University | 15 | 2008-05-01 | 2018-09-11 |
| A Study of Pharmacokinetics and Safety of Alefacept in Caucasian and Japanese Healthy Volunteers alefacept, placebo - Pharmacokinetics of Alefacept | Phase 1 | Completed | Astellas Pharma Inc | 75 | 2008-03-01 | 2013-02-28 |
| Alefacept in Subjects With Chronic Plaque Psoriasis Who Failed to Respond to Anti-TNF Therapy alefacept - Chronic Plaque Psoriasis | Phase 4 | Terminated | John Murray | 1 | 2008-02-01 | 2013-02-22 |
| A Study to Assess the Safety and Efficacy of Alefacept in Kidney Transplant Recipients Alefacept, tacrolimus, basiliximab - Kidney Transplantation | Phase 2 | Completed | Astellas Pharma Inc | 323 | 2008-02-01 | 2015-12-11 |
| Study to Evaluate the Safety and Efficacy of Alefacept (Amevive) in Subjects With Moderate to Severe Atopic Dermatitis Alefacept - Atopic Dermatitis | Phase 4 | Completed | Rush University Medical Center | 5 | 2008-01-01 | 2011-03-10 |
| A Study to Assess the Efficacy and Safety of Alefacept in Kidney Transplant Recipients Alefacept, placebo, Tacrolimus - De Novo Kidney Transplantation | Phase 2 | Completed | Astellas Pharma Inc | 218 | 2007-12-01 | 2016-02-04 |
| Assess the Efficacy and Safety of Alefacept With Narrow Band Ultraviolet B Phototherapy (nbUVB) vs. Alefacept Alone in Chronic Plaque Psoriasis Subjects alefacept, Narrow Band UVB Phototherapy - Plaque Psoriasis | Phase 4 | Completed | Astellas Pharma Inc | 98 | 2007-10-01 | 2013-01-08 |
| Open Label Study of Alefacept Injections to Patients With Moderate to Severe Psoriasis Intralesional Alefacept - Moderate to Severe Psoriasis | Not applicable | Completed | University of California, San Francisco | 18 | 2007-09-01 | 2019-04-18 |
| Study to Evaluate the Immune Response to Pneumococcal Vaccine in Alefacept-treated Adults With Chronic Plaque Psoriasis alefacept, polyvalent pneumococcal vaccine - Chronic Plaque Psoriasis | Phase 4 | Completed | Astellas Pharma Inc | 43 | 2007-07-01 | 2012-02-02 |
| Alefacept for Chronic Graft Versus Host Disease Alefacept - Resistant Chronic GVHD | Phase 1 / Phase 2 | Completed | Hadassah Medical Organization | 20 | 2006-10-01 | 2015-04-21 |
| Alefacept for Prevention of Graft Versus Host Disease (GVHD) Alefacept (AMEVIVE®), control group - Graft Versus Host Disease | Phase 3 | Terminated | Hadassah Medical Organization | 26 | 2006-06-01 | 2015-04-21 |
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Psoriasis (12) · Anemia, Aplastic (2) · Bronchiolitis Obliterans Syndrome (2) · Dermatitis, Atopic (2) · Skin Diseases (2) · Alopecia Areata (1) · Anemia, Diamond-Blackfan (1) · Anemia, Sickle Cell (1) · Arthritis, Psoriatic (1) · Autoimmune Diseases (1) · Chediak-Higashi Syndrome (1) · Dermatitis (1) · Dyskeratosis Congenita (1) · Fanconi Anemia (1) · Graft vs Host Disease (1)
Astellas Pharma Inc (14) · Hadassah Medical Organization (2) · Biogen (1) · Charite University, Berlin, Germany (1) · Dana-Farber Cancer Institute (1) · Emory University (1) · Insel Gruppe AG, University Hospital Bern (1) · John Murray (1) · Joshua Zeichner (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Medical University of Graz (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Northwestern University (1) · Rush University Medical Center (1)
United States (25) · Canada (10) · Germany (6) · Austria (4) · Belgium (3) · France (3) · Netherlands (3) · United Kingdom (3) · Denmark (2) · Israel (2) · Poland (2) · Spain (2) · Switzerland (2) · Bulgaria (1) · Czechia (1)
Michael Y Shapira, MD (2) · Alexandra B. Kimball, MD, MPH (1) · Barry Ticho, MD (1) · Corey Cutler, MD (1) · Donald E Hricik, MD (1) · John C Murray, MD (1) · John Horan, MD (1) · John Koo, MD (1) · Joshua Zeichner, MD (1) · Kenneth Gordon, MD (1) · Lyn C Guenther, MD, FRCPC (1)
PMID 17709660, PMID 22506829, PMID 24622414, PMID 26095669, PMID 26193635, PMID 27208317
2008 (1), P30CA015083 (1), P50CA097274 (1)