24 completed, 6 unknown, 5 recruiting, 4 terminated. 14 Phase 2, 7 Not applicable, 5 Phase 1, 2 Phase 3, 1 Phase 4.
Follow Leukoplakia, Oral: new trials by email Literature Review of Leukoplakia, Oral trials Research Report on Leukoplakia, Oral
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer | Phase 2 | Not yet recruiting | University of Massachusetts, Boston | 65 | 2026-09-01 | 2026-03-19 |
| Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral Leukoplakia Non-invasive Photo Dynamic Therapy using LED of wavelength ranging from 630-660nm( Fluence 15 J/cm2) as light source and 2.5% TB as photosensitizer, Topical application of Calcipotriol ointment 0.005% twice a day for 4 weeks along with preventive and conventional therapy, Conventional non-invasive management : All subjects in the two groups will receive the same standard conventional non- invasive management advised for OL as per current scientific evidence - Oral Leukoplakia | Phase 3 | Not yet recruiting | Dr. Shalini Gupta | 166 | 2026-04-01 | 2026-03-06 |
| Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia Metformin Hydrochloride, Placebo - Oral Leukoplakia | Phase 2 | Recruiting | Cairo University | 34 | 2026-02-01 | 2026-02-06 |
| Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders Toluidine blue staining of the lesion and cytological smears - Oral Lichen Planus, Oral Leukoplakia | Not yet recruiting | Ain Shams University | 120 | 2025-12-16 | 2026-01-06 | |
| Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment Coenzyme Q10 gel, Topical curcumin gel - Oral Leukoplakia | Not applicable | Recruiting | Alexandria University | 34 | 2025-11-25 | 2026-01-12 |
| Fenretinide Mucoadhesive Patch: Evaluation of Oral Cancer Prevention Efficacy in Adults With Premalignant Oral Lesions. Mucoadhesive fenretinide-releasing system (FMS) - Oral Leukoplakia, Oral Dysplasia | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 7 | 2025-10-14 | 2026-09-25 |
| Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia Calcipotriol 0.005% gel, ALA mediated PDT - Oral Leukoplakia | Phase 2 / Phase 3 | Active not recruiting | Alexandria University | 30 | 2025-07-16 | 2026-06-22 |
| Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia pioglitazone-metformin - Oral Leukoplakia | Phase 2 | Recruiting | University of Minnesota | 36 | 2025-01-01 | 2026-07-29 |
| Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics Saliva, Oral Lichen Planus | Completed | Kocaeli University | 21 | 2024-12-25 | 2026-02-18 | |
| SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography OCT (Optical Coherence Tomography) - Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder | Recruiting | University of Palermo | 200 | 2024-03-13 | 2025-05-23 | |
| Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study Oral Leukoplakia | Unknown | King Khalid University | 160 | 2024-02-29 | 2024-02-21 | |
| Identification of Oral Lesions Through an Autofluorescence System Screening examination - Oral Leukoplakia, Autofluorescence | Not applicable | Completed | Federico II University | 200 | 2023-06-01 | 2026-09-02 |
| Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia Biopsy, Biospecimen Collection, Extended Release Metformin Hydrochloride - Erythroplakia, Oral Leukoplakia | Phase 2 | Active not recruiting | University of Arizona | 34 | 2023-01-12 | 2026-09-28 |
| Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions Real-time Polymerase Chain Reaction technique - Potentially Malignant Lesions, Oral Lichen Planus | Completed | Fayoum University | 45 | 2022-11-01 | 2023-09-13 | |
| Intralesional 5-fluorouracil Injection for the Treatment of Oral Leukoplakia 5-fluorouracil - Oral Leukoplakia | Phase 1 | Withdrawn | University of California, San Francisco | 2022-09-30 | 2022-09-22 | |
| This Study is to Evaluate the Safety and Pharmacokinetics of SBS-101 in Patients With Oral Premalignant Lesions SBS-101, Placebo - Leukoplakia, Oral | Phase 1 | Withdrawn | Skyline Biosciences | 2022-01-01 | 2021-10-19 | |
| FENDRR and CRNDE With DUSP1 and DMBT1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma Oral Leukoplakia (OL), Oral Squamous Cell Carcinoma (OSCC) | Completed | Amina Fouad Farag | 62 | 2021-12-26 | 2026-10-30 | |
| Oral Cancer Screening and Education in Hong Kong No intervention utilised - Oral Cancer, Oral Leukoplakia | Unknown | The University of Hong Kong | 3190 | 2021-08-01 | 2020-07-27 | |
| Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions Salivary Gamma-synuclein, Incisional biopsy, Conventional visual and tactile examination - Oral Cancer, Oral Lichen Planus | Unknown | Cairo University | 69 | 2021-03-10 | 2021-02-01 | |
| Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach Surgical excision of the lesion, Wait and see approach - Leukoplakia, Oral | Not applicable | Unknown | University of Milan | 310 | 2020-09-01 | 2024-03-07 |
Showing 20 of 47. Sign in to see all of them.
Mouth Neoplasms (15) · Lichen Planus, Oral (13) · Squamous Cell Carcinoma of Head and Neck (5) · Erythroplasia (4) · Precancerous Conditions (4) · Head and Neck Neoplasms (3) · Leukoplakia (3) · Mouth Diseases (3) · Oropharyngeal Neoplasms (3) · Tongue Neoplasms (3) · AIDS-Related Complex (2) · AIDS-Related Opportunistic Infections (2) · HIV Infections (2) · Lichen Planus (2)
Neoplasms by Site (47) · Pathological Conditions, Anatomical (47) · Pathological Conditions, Signs and Symptoms (47) · Neoplasms (46) · Stomatognathic Diseases (46) · Head and Neck Neoplasms (44) · Leukoplakia (44) · Mouth Diseases (44) · Precancerous Conditions (43) · Mouth Neoplasms (32) · Lichenoid Eruptions (14) · Skin Diseases (14) · Skin Diseases, Papulosquamous (14) · Skin and Connective Tissue Diseases (14) · Lichen Planus (12)
Biopsy (3) · Metformin (3) · Photochemotherapy (3) · Aminolevulinic Acid (2) · Pioglitazone (2) · 1-phenyl-3,3-dimethyltriazene (1) · Acyclovir (1) · Aspirin (1) · Behavior Therapy (1) · Catechin (1) · Celecoxib (1) · Dapsone (1) · Dihematoporphyrin Ether (1) · Ethanol (1) · Fluconazole (1)
National Cancer Institute (NCI) (7) · Cairo University (3) · Alexandria University (2) · National Taiwan University Hospital (2) · Ain Shams University (1) · All India Institute of Medical Sciences (1) · Amina Fouad Farag (1) · Beijing Stomatological Hospital, Capital Medical University (1) · Beni-Suef University (1) · Dalarna County Council, Sweden (1) · Dana-Farber Cancer Institute (1) · Dr. Shalini Gupta (1) · Fayoum University (1) · Federico II University (1) · Fox Chase Cancer Center (1)
United States (20) · Egypt (7) · India (5) · Italy (4) · Canada (3) · Taiwan (2) · United Kingdom (2) · China (1) · Germany (1) · Sweden (1) · Turkey (Türkiye) (1)
Frank Ondrey (2) · Scott M Lippman (2) · Chun-Pin Chiang, DMSc (1) · Eglal M Moussa, PhD oral medicine (1) · Eva Szabo, M.D. (1) · Falk Wehrhan, MD, DMD (1) · Francisco Civantos, Jr., MD (1) · Frank Meyskens (1) · Giovanni Lodi, PhD, DMD (1) · Glenn Hanna, MD (1) · Hisham Mehanna, MD (1) · Jay Boyle (1) · Jay O. Boyle, M.D. (1) · Jonathan Celli, PhD (1)
PMID 39532605, PMID 39584361, PMID 14520092, PMID 23055220, PMID 23639862, PMID 33813637, PMID 34255745, PMID 37971722, PMID 40973523
N01CN35159 (2), P30CA016672 (2), P30CA023074 (2), N01CN00031 (1), N01CN35153 (1), P30CA008748 (1), P30CA060553 (1), R01CA227273 (1), U01CA072294 (1), U01CA279862 (1), UG1CA242596 (1)