27 completed, 15 unknown, 13 terminated, 7 recruiting. 23 Phase 2, 14 Phase 3, 8 Not applicable, 7 Phase 1, 3 Phase 4.
Follow Pemphigus: new trials by email Literature Review of Pemphigus trials Research Report on Pemphigus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rituximab With Corticosteroids Versus Corticosteroids Plus Azathioprine for Moderate-to-Severe Pemphigus Vulgaris Rituxan (rituximab), Azathioprine (AZA)' plus corticosteroids - Pemphigus Vulgaris, Rituximab (RTx) | Early Phase 1 | Not yet recruiting | Khyber Teaching Hospital | 92 | 2026-12-02 | 2026-08-18 |
| CD19 CAR-T Therapy for Refractory Pemphigus Vulgaris Autologous CD19 CAR-T cells - Pemphigus Vulgaris | Not applicable | Recruiting | Jinbo Chen | 3 | 2026-01-15 | 2026-07-02 |
| Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients Clinical Periodontal and Oral Evaluation - Pemphigus Vulgaris (PV), Periodontal Diseases | Completed | Saglik Bilimleri Universitesi | 25 | 2025-11-01 | 2026-10-07 | |
| A Randomized Study on Pemphigus Treatment With Humanized CD38 Antibody CM313. CM313 (SC), Glucocorticoids - Pemphigus Disease, Pemphigus Vulgaris (PV) | Phase 1 / Phase 2 | Not yet recruiting | Chao Ji | 100 | 2025-10-01 | 2024-10-29 |
| Low-level Laser Therapy on Oral Pemphigus Vulgaris Patients. Low energy diode Laser, Medication - Pemphigus Vulgaris | Not applicable | Not yet recruiting | Cairo University | 22 | 2025-06-01 | 2025-05-14 |
| Impact of a Lifestyle Program on Quality of Life in Pemphigus Patients Mediterranean Diet and exercise - Pemphigus Disease | Not applicable | Not yet recruiting | Assiut University | 44 | 2025-05-10 | 2025-03-30 |
| Trichoscopy as a Monitoring Tool for Activity and Remission in Pemphigus Vulgaris: A Clinical Study Supported by Immunological Evaluation. Trichoscopy - Pemphigus Vulgaris (PV) | Not yet recruiting | Assiut University | 62 | 2025-05-01 | 2025-03-07 | |
| A Single-center Study of CM313 in Patients With Pemphigus CM313 injection, glucocorticoids - Pemphigus | Not applicable | Not yet recruiting | Sichuan Provincial People's Hospital | 20 | 2025-04-01 | 2025-04-01 |
| Comparison of a Personalized Maintenance Therapy With the Standard Treatment in Pemphigus RiTUXimab Injection - Pemphigus, Dermatologic Disease | Phase 4 | Recruiting | University Hospital, Rouen | 133 | 2024-12-04 | 2026-02-20 |
| A Clinical Study of B007 in the Treatment of Pemphigus. B007 - Pemphigus | Phase 2 / Phase 3 | Recruiting | Shanghai Jiaolian Drug Research and Development Co., Ltd | 132 | 2024-07-12 | 2026-05-05 |
| Effect of Topical Insulin on Healing Rate of Pemphigus Lesions insulin glargine, human insulin, 0.9% Normal Saline - Pemphigus Vulgaris, Skin Erosion | Phase 2 | Completed | Alexandria University | 20 | 2024-06-22 | 2026-03-10 |
| Evaluating Legit.Health Plus Support for Improving Diagnosis of Generalized Pustular Psoriasis and Other Skin Conditions Among Primary Care Physicians and Dermatologists AI-based medical device for aided diagnosis in Dermatology - Pustular Psoriasis (PP), Generalized Pustular Psoriasis (GPP) | Completed | AI Labs Group S.L | 15 | 2024-06-01 | 2026-02-24 | |
| Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases. AB-101, Rituximab, Cyclophosphamide - Rheumatoid Arthritis, Pemphigus Vulgaris | Phase 1 | Recruiting | IRIS Research and Development, LLC | 30 | 2024-05-15 | 2024-09-03 |
| Coagulation Activation in Patients With Pemphigus prothrombin fragment 1+2 - Pemphigus | Unknown | Assiut University | 54 | 2024-03-01 | 2024-02-29 | |
| Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients Galectin 3 measurement in serum and saliva by ELIZA - Galectin-3 and Pemphigus | Unknown | Assiut University | 60 | 2023-08-08 | 2023-08-15 | |
| Efficacy and Safety Evaluation of Anti-CD20 Monoclonal Antibody Combined with Azathioprine and Corticosteroids in the Treatment of Pemphigus Vulgaris Ofatumumab subcutaneous injection - Pemphigus, Pemphigus Vulgaris (PV) | Completed | Chao Ji | 38 | 2023-01-01 | 2024-10-23 | |
| Ozonated Olive Oil in Treatment of Pemphigus Vulgaris and Bullous Pemphigoid Ozonated olive oil, Topical garamycin cream - Pemphigus Vulgaris, Bullous Pemphigoid | Phase 3 | Unknown | Cairo University | 30 | 2022-11-01 | 2022-11-08 |
| Validation of 5-Point Investigator Global Assessments for Pemphigus Investigator Global Assessments (IGAs) - Pemphigus | Unknown | Premier Specialists, Australia | 40 | 2022-09-21 | 2022-09-19 | |
| ONO-4059 Study in Patients With Steroid-resistant Pemphigus ONO-4059, ONO-4059 placebo - Pemphigus, Steroid-resistant Pemphigus | Phase 3 | Active not recruiting | Ono Pharmaceutical Co., Ltd. | 34 | 2022-08-15 | 2026-07-20 |
| Role of Tzanck Smear in Determining Pemphigus Vulgaris Disease Activity Tzanck smear - Pemphigus Vulgaris | Unknown | Istanbul Medeniyet University | 50 | 2022-01-01 | 2023-03-01 |
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Autoimmune Diseases (6) · Pemphigoid, Bullous (5) · Pemphigoid, Benign Mucous Membrane (4) · Skin Diseases (4) · Lupus Erythematosus, Systemic (3) · Rare Diseases (3) · Arthritis, Rheumatoid (2) · Hidradenitis Suppurativa (2) · Hypersensitivity (2) · Immune System Diseases (2) · Lichen Planus, Oral (2) · Multiple Sclerosis (2) · Psoriasis (2) · Skin Diseases, Vesiculobullous (2)
Skin and Connective Tissue Diseases (73) · Immune System Diseases (71) · Skin Diseases, Vesiculobullous (71) · Skin Diseases (69) · Autoimmune Diseases (67) · Pathological Conditions, Signs and Symptoms (6) · Disease Attributes (5) · Eye Diseases (5) · Infections (5) · Mouth Diseases (5) · Pathologic Processes (5) · Stomatognathic Diseases (5) · Conjunctival Diseases (4) · Connective Tissue Diseases (4) · Lung Diseases (4)
Rituximab (11) · Mycophenolic Acid (4) · Prednisone (4) · Azathioprine (3) · Cyclophosphamide (3) · Dexamethasone (3) · Glucocorticoids (2) · Immunoglobulins, Intravenous (2) · ofatumumab (2) · 2019-nCoV Vaccine mRNA-1273 (1) · Abatacept (1) · Acetaminophen (1) · Ad26COVS1 (1) · Adrenal Cortex Hormones (1) · BNT162 Vaccine (1)
Assiut University (5) · University Hospital, Rouen (5) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · argenx (3) · Assistance Publique - Hôpitaux de Paris (2) · Cairo University (2) · Chao Ji (2) · Hoffmann-La Roche (2) · Novartis Pharmaceuticals (2) · Principia Biopharma, a Sanofi Company (2) · Ruijin Hospital (2) · AI Labs Group S.L (1) · Alexandria University (1) · Alexion Pharmaceuticals, Inc. (1) · Cabaletta Bio (1)
United States (25) · France (14) · China (11) · Israel (10) · Turkey (Türkiye) (8) · Australia (7) · Germany (7) · Greece (6) · Italy (6) · Ukraine (6) · Bulgaria (5) · Spain (5) · Japan (4) · Poland (4) · United Kingdom (4)
Amit Pandya, MD (2) · Neil Korman, MD (2) · Victoria Werth, MD (2) · Alessandro Villa, DDS, PhD, MPH (1) · Alexandra B Kimball, MD, MPH (1) · Amit Bar-Or, MD, FRCP (1) · Anna Haemel, MD (1) · Antonio Martorell, PhD (1) · Bruce Strober, MD (1) · Cabaletta Bio (1) · Carmen I Farid, MB BCh, MD (1) · Cheyda Chams-Davatchi, MD (1)
PMID 19357707, PMID 16702494, PMID 1720352, PMID 17687130, PMID 18209165, PMID 18602282, PMID 20410913, PMID 21167320, PMID 21955378, PMID 22026362, PMID 24433179, PMID 25123295, PMID 26543381, PMID 26597100, PMID 27287854, PMID 28495498, PMID 28761292, PMID 31396203, PMID 32272980, PMID 32642810, PMID 33433957, PMID 33691711, PMID 33767069, PMID 34097368, PMID 34126109, PMID 34214256, PMID 34369370, PMID 34535102, PMID 34608631, PMID 35663943, PMID 37523970, PMID 37549933, PMID 37965194, PMID 38608709, PMID 40374120, PMID 40787442, PMID 41156189, PMID 41289027, PMID 41312452, PMID 42201777, PMID 9424089
2014 (1), 2015 (1), 2017 (1), 2018 (1)