7 recruiting, 4 completed, 4 unknown, 3 not yet recruiting. 7 Not applicable, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 4, Unknown 2, Completed 1 |
| Phase 4 | 3 | Active not recruiting 1, Recruiting 1, Unknown 1 |
Follow Left Atrial Appendage Closure: new trials by email Literature Review of Left Atrial Appendage Closure trials Research Report on Left Atrial Appendage Closure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Registry on Luma Vision's VERAFEYE System (ENLIgHT) VERAFEYE System - Atrial Fibrillation, Left Atrial Appendage Closure | Not yet recruiting | LUMA Vision Ltd. | 50 | 2027-12-15 | 2026-11-03 | |
| OPTION-EMEA Clinical Trial Concomitant pulsed field ablation (PFA) and left atrial appendage closure (LAAC) during one interventional case, Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure - Atrial Fibrillation (AF), Stroke Prevention in Patients With Atrial Fibrillation | Not applicable | Recruiting | Boston Scientific Corporation | 500 | 2026-06-18 | 2026-10-27 |
| CLOT-LESS - CLOsure Tailored: LEss Antithrombotic Strategy After LAAC for Stroke Prevention Left Atrial Appendage Closure, Apixaban 2.5 mg BID, Standard-dose DOAC - Atrial Fibrillation, Stroke Prevention in Patients With Atrial Fibrillation | Recruiting | National Medical Research Center for Therapy and Preventive Medicine | 464 | 2026-04-01 | 2026-05-08 | |
| Agilis RF TSP Early Feasibility Study Transseptal procedure with Agilis RF TSP System. - Cardiac Arrythmias, Left Atrial Appendage Closure | Not applicable | Recruiting | Abbott Medical Devices | 60 | 2026-02-16 | 2026-06-02 |
| Preventing Neurologic Complications in Valve Surgery Left Atrial Appendage (LAA) Suture Closure, Surgical Valve Surgery - Left Atrial Appendage Closure | Not yet recruiting | China National Center for Cardiovascular Diseases | 100 | 2026-01-27 | 2026-02-02 | |
| CardioLogical Interventions and Acute strOke Treatment sTudy Acute Ischemic Stroke AIS, Stroke Treatment | Not yet recruiting | University of L'Aquila | 400 | 2026-01-01 | 2026-01-07 | |
| WATCHMAN FLX Pro European Registry Left atrial appendage closure - Non-valvular Atrial Fibrillation (AF), Left Atrial Appendage Closure | Active not recruiting | Boston Scientific Corporation | 189 | 2025-12-17 | 2026-10-02 | |
| Data Collection for Echocardiography-Based Software Assessment No investigational intervention administered - Atrial Fibrillation, Left Atrial Appendage Closure | Completed | Anumana, Inc. | 100 | 2025-07-11 | 2025-12-24 | |
| Non-antithrombotic Versus. Single Antiplatelet Therapy Following Left Atrial Appendage Closure Single Antiplatelet Therapy or No Therapy (Control), Non-Antithrombotic Therapy - Nonvalvular Atrial Fibrillation, Aspirin | Phase 4 | Recruiting | OCEAN-SHD Study Group | 500 | 2025-05-29 | 2025-08-15 |
| Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion Intracardiac Echocardiography, Traditional transesophageal echocardiography - Left Atrial Appendage Closure | Not applicable | Recruiting | Baylor Research Institute | 444 | 2025-02-25 | 2026-09-03 |
| Feasibility Study on the VERAFEYE System VERAFEYE System - Atrial Septal Defect, Atrial Fibrillation | Not applicable | Completed | LUMA Vision Ltd. | 18 | 2025-01-09 | 2026-02-10 |
| Oral Anticoagulation Versus Left Atrial Appendage Occlusion Added to Direct Oral Anticoagulation in Patients with Stroke Despite Oral LAA Closurse - Left Atrial Appendage Closure | Not applicable | Recruiting | Hospital Clinic of Barcelona | 380 | 2024-07-22 | 2025-03-11 |
| The Usefulness of Biatrial 3D Printing to Plan Transseptal Puncture for the Left Atrial Appendage Closure Left atrial appendage closure - Atrial Fibrillation, Left Atrial Appendage Closure | Not applicable | Unknown | Charles University, Czech Republic | 60 | 2021-01-01 | 2023-02-24 |
| Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure Rivaroxaban, dabigatran, apixaban, or edoxaban, Clopidogrel -75 mg/day, Low dose aspirin -80 to 125 mg/day- - Left Atrial Appendage Closure, Thrombosis | Phase 4 | Active not recruiting | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | 510 | 2018-09-01 | 2026-03-27 |
| Comparison of Amplatzer Amulet and Watchman Device in Patients Undergoing Left Atrial Appendage Closure. (SWISS-APERO) Amplatzer Amulet for left atrial appendage closure, Watchman/FLX for left atrial appendage closure - Left Atrial Appendage Closure | Not applicable | Unknown | Insel Gruppe AG, University Hospital Bern | 200 | 2018-06-19 | 2024-05-23 |
| Austrian Left Atrial Appendage Closure Registry LAAC - Atrial Fibrillation, Left Atrial Appendage Closure | Recruiting | Medical University of Graz | 200 | 2017-05-16 | 2026-10-16 | |
| A Pilot Study of Edoxaban in Patients With Non-Valvular Atrial Fibrillation and Left Atrial Appendage Closure Edoxaban, WATCHMAN LAA Closure, Aspirin and Clopidogrel - Non-Valvular Atrial Fibrillation, Left Atrial Appendage Closure | Phase 4 | Unknown | Scripps Health | 75 | 2017-03-23 | 2017-07-11 |
| The Evaluation of Thrombogenicity in Patients Undergoing WATCHMAN Left Atrial Appendage Closure Trial WATCHMAN Left Atrial Appendage Closure - Left Atrial Appendage Closure, WATCHMAN Device Implantation | Completed | Inova Health Care Services | 35 | 2017-03-01 | 2024-03-29 | |
| China REgistry of WATCHMAN left atrial appendage closure device implantation - Atrial Fibrillation, Left Atrial Appendage Closure | Unknown | Fu Wai Hospital, Beijing, China | 413 | 2016-11-01 | 2017-01-09 | |
| Left Atrial Appendage Closure With the LAmbre LAA closure with LAmbre - Atrial Fibrillation, Left Atrial Appendage Closure | Completed | Shanghai 10th People's Hospital | 66 | 2014-04-14 | 2017-05-10 |
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Atrial Fibrillation (10) · Stroke (3) · Hemorrhage (2) · Thrombosis (2) · Cardiovascular Diseases (1) · Heart Septal Defects, Atrial (1) · Ischemic Stroke (1) · Thromboembolism (1)
Cardiovascular Diseases (13) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Arrhythmias, Cardiac (10) · Heart Diseases (10) · Vascular Diseases (6) · Brain Diseases (4) · Central Nervous System Diseases (4) · Cerebrovascular Disorders (4) · Nervous System Diseases (4) · Embolism and Thrombosis (3) · Cardiovascular Abnormalities (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Heart Defects, Congenital (1)
Left Atrial Appendage Closure (6) · apixaban (2) · edoxaban (2) · Aspirin (1) · BID protein, human (1) · Clopidogrel (1) · Dabigatran (1) · N(4)-oleylcytosine arabinoside (1) · Rivaroxaban (1) · Sutures (1) · Warfarin (1)
Boston Scientific Corporation (2) · LUMA Vision Ltd. (2) · Abbott Medical Devices (1) · Anumana, Inc. (1) · Baylor Research Institute (1) · Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec (1) · Charles University, Czech Republic (1) · China National Center for Cardiovascular Diseases (1) · Fu Wai Hospital, Beijing, China (1) · Hospital Clinic of Barcelona (1) · Inova Health Care Services (1) · Insel Gruppe AG, University Hospital Bern (1) · Medical University of Graz (1) · National Medical Research Center for Therapy and Preventive Medicine (1) · OCEAN-SHD Study Group (1)
United States (6) · Italy (4) · Spain (3) · Belgium (2) · China (2) · France (2) · Switzerland (2) · Austria (1) · Canada (1) · Croatia (1) · Czechia (1) · Denmark (1) · Germany (1) · Ireland (1) · Japan (1)
Arian Sultan, Prof. MD (1) · Emmanuel Teiger, Prof (1) · Frederic Anselme, Prof (1) · Karapet Davtyan, Professor (1) · Leon Ptaszek, MD, PhD (1) · Marco Valgimigli, Prof (1) · Marek Grygier, Prof. MD, PHD (1) · Matthew J Price, MD (1) · Nicolas Meneveau, Prof (1) · Pavel Osmancik (1) · Yawei Xu, MD, PHD (1)
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