17 recruiting, 9 completed, 7 not yet recruiting, 7 unknown. 16 Not applicable, 7 Phase 3, 3 Phase 2, 2 Phase 1.
Follow Large Vessel Occlusion: new trials by email Literature Review of Large Vessel Occlusion trials Research Report on Large Vessel Occlusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Yongjun Wang | 1440 | 2026-10-16 | 2026-10-22 |
| Head of Bed After Ischemic Stroke Thrombectomy (HoBIT) Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater - Large Vessel Occlusion, Stroke | Not applicable | Recruiting | Population Health Research Institute | 2240 | 2026-09-03 | 2026-09-18 |
| A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke Plunger Technique, Static Manual Aspiration Thrombectomy - Acute Ischemic Stroke Patients, Large Vessel Occlusion | Not applicable | Recruiting | Vanderbilt University Medical Center | 500 | 2026-08-04 | 2026-10-06 |
| INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical Thrombectomy Alteplase, Endovascular thrombectomy - Stroke, Acute Ischemic, Large Vessel Occlusion | Phase 3 | Recruiting | 115 People's Hospital | 416 | 2026-08-01 | 2026-09-25 |
| Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel Occlusion Prospective Mechanical Thrombectomy Cohort - Acute Ischemic Stroke, Large Vessel Occlusion | Not yet recruiting | Zhongshan Hospital Xiamen University | 50 | 2026-08-01 | 2026-08-10 | |
| Sivelestat Sodium as an Adjunct to Endovascular Thrombectomy for Acute Anterior Circulation Large-Vessel Occlusion Sivelestat sodium, Placebo, Endovascular Thrombectomy - Acute Ischemic Stroke, Large Vessel Occlusion | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 868 | 2026-06-22 | 2026-06-25 |
| Direct Angio Suite Acute Stroke Intervention With CT/DSA Hybrid Emergency Stroke Unit Direct Angio Suite Acute Stroke Intervention With CT/DSA Hybrid Emergency Stroke Unit, Conventional Thrombectomy - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 232 | 2026-06-08 | 2026-06-26 |
| Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b) Non-invasive convective head cooling, Standard of Care (SOC) - Stroke, Acute Ischemic Stroke | Not applicable | Not yet recruiting | Auckland City Hospital | 182 | 2026-04-10 | 2026-04-13 |
| Advancing Reperfusion Therapy for Ischemic Stroke: Direct Transfer to Angiography Suite for Patients With Suspected Large Vessel Occlusion direct transfer to angiography suite, conventional CT/MRI triage strategy - Ischemic Stroke, Large Vessel Occlusion | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 568 | 2026-03-31 | 2026-03-12 |
| Intra-arterial Methylprednisolone After Endovascular Thrombectomy The methylprednisolone sodium succinate group, The placebo group - Ischemia Stroke, Thrombectomy | Phase 2 | Recruiting | Tang-Du Hospital | 210 | 2026-03-31 | 2026-04-08 |
| Evaluation of a Point-of-care Lateral Flow Assay in Glial Fibrillary Acidic Protein (GFAP) and D-dimer in Diagnosis of Large Vessel Occlusion Acute Ischemic Stroke in a Pediatric Hospital Point of Care Rapid Assay - Stroke Code, Large Vessel Occlusion | Not yet recruiting | Boston Children's Hospital | 250 | 2026-03-01 | 2026-03-16 | |
| Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke transcutaneous auricular vagal nerve stimulation, Sham transcutaneous vagal nerve stimulation - Large Vessel Occlusion, Acute Ischemic Stroke | Not applicable | Recruiting | Washington University School of Medicine | 65 | 2026-02-23 | 2026-04-13 |
| Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 572 | 2026-01-06 | 2026-08-19 |
| Tenecteplase vs Medical Management in 4.5-24h LVO no Access to EVT TNK, Standard medical treatment - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | The First Affiliated Hospital of University of Science and Technology of China | 794 | 2025-11-01 | 2025-09-11 |
| Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study Sodium Sivelestat - Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation | Not applicable | Completed | Xuanwu Hospital, Beijing | 20 | 2025-10-28 | 2026-03-24 |
| Evaluation of the CONDA Stent Retriever in Acute Ischemic Stroke Mechanical Thrombectomy using the CONDA Stent Retriever - Acute Ischemic Stroke, Large Vessel Occlusion | Not applicable | Recruiting | Anaconda Biomed S.L. | 50 | 2025-10-01 | 2025-09-16 |
| Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort Not applicable- observational study - Large Vessel Occlusion, Acute Ischemic Stroke | Recruiting | First Affiliated Hospital of Wannan Medical College | 500 | 2025-04-27 | 2025-05-11 | |
| Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment Semaglutide 0.5 mg, Standard medical treatment - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | Wei Hu | 390 | 2025-02-01 | 2025-01-23 |
| Mechanical Thrombectomy Blood Flow Reversal Mechanical thrombectomy via blood flow reversal using BOBBY balloon guide catheter - Stroke, Large Vessel Occlusion | Phase 1 | Terminated | MediSys Health Network | 3 | 2025-01-22 | 2025-07-24 |
| Image Detection of Impaired Microcirculatory Reperfusion CT Perfusion - Ischemic Stroke, Acute, Large Vessel Occlusion | Recruiting | University of Cincinnati | 40 | 2024-09-30 | 2025-08-01 |
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Ischemic Stroke (39) · Stroke (9) · Thrombosis (4) · Brain Ischemia (2) · Reperfusion Injury (2) · Brain Infarction (1) · Cerebral Infarction (1) · Cerebrovascular Disorders (1) · Hypothermia (1) · Ischemia (1)
Brain Diseases (42) · Cardiovascular Diseases (42) · Central Nervous System Diseases (42) · Nervous System Diseases (42) · Vascular Diseases (42) · Cerebrovascular Disorders (41) · Stroke (33) · Pathological Conditions, Signs and Symptoms (6) · Pathologic Processes (5) · Embolism and Thrombosis (4) · Infarction (2) · Ischemia (2) · Necrosis (2) · Postoperative Complications (2) · Body Temperature Changes (1)
Tenecteplase (3) · Standard of Care (2) · Thrombectomy (2) · Albumins (1) · Cilostazol (1) · Ischemic Postconditioning (1) · Tissue Plasminogen Activator (1) · semaglutide (1)
Tianjin Huanhu Hospital (6) · Beijing Tiantan Hospital (4) · Changhai Hospital (3) · Xuanwu Hospital, Beijing (3) · 115 People's Hospital (1) · ASST Santi Paolo e Carlo (1) · Anaconda Biomed S.L. (1) · Assistance Publique - Hôpitaux de Paris (1) · Auckland City Hospital (1) · Biomedical Solutions Inc. (1) · Boston Children's Hospital (1) · First Affiliated Hospital of Wannan Medical College (1) · Heuron Inc. (1) · MediSys Health Network (1) · Medical University of South Carolina (1)
China (24) · United States (7) · France (2) · Germany (2) · Italy (2) · Canada (1) · Egypt (1) · Hungary (1) · New Zealand (1) · Paraguay (1) · Portugal (1) · Saudi Arabia (1) · South Korea (1) · Spain (1) · Switzerland (1)
Jianmin Liu, M.D. (2) · Ming Wei, doctorate (2) · Alan Barber, PhD (1) · Aristeidis Katsanos, MD (1) · Atila Oscan Ozdimar, MD, PhD (1) · Benqiang Deng, M.D. (1) · Charles Majoie, M.D. (1) · David Fiorella, M.D. (1) · Donald Frei, M.D. (1) · Doug Campbell, MBChB (1) · Elena Ballabio, MD (1) · Faisal Alghamdi, MD (1) · Jianimin Liu, M.D. (1)
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