16 recruiting, 15 completed, 11 not yet recruiting, 2 active not recruiting. 32 Not applicable, 4 Phase 2, 3 Phase 4, 2 Phase 1, 1 Phase 3.
Follow Knee Osteoarthritis (Knee OA): new trials by email Literature Review of Knee Osteoarthritis (Knee OA) trials Research Report on Knee Osteoarthritis (Knee OA)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis Atibuclimab, saline placebo - Knee Osteoarthritis (Knee OA) | Phase 1 | Not yet recruiting | VA Office of Research and Development | 40 | 2027-01-01 | 2026-07-15 |
| Holistic Healing for Knee Osteoarthritis Trayodashang Guggulu, Ashwagandha Churna, Janubasti - Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | All India Institute of Medical Sciences, Jodhpur | 300 | 2026-12-01 | 2026-11-06 |
| Evaluation of the Effects of Pulsed Electromagnetic Field on Inflammatory Knee Osteoarthritis Pulsed Electromagnetic Field (PEMF) Therapy, Sham Pulsed Electromagnetic Field (PEMF) Treatments - Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 50 | 2026-09-15 | 2026-09-22 |
| Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance Duloxetine, Placebo - Knee Osteoarthritis (Knee OA), Chronic Pain | Phase 4 | Recruiting | Benedict Alter | 85 | 2026-09-15 | 2026-10-21 |
| Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain Inspiratory muscle training, Sham inspiratory muscle training - Knee Osteoarthritis, Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 80 | 2026-09-01 | 2026-07-16 |
| Phase II/III Randomized Trial of UC-MSC Secretome vs Sodium Hyaluronate in Knee Osteoarthritis UC-MSC-Derived Secretome, Sodium Hyaluronate (Hyalein) - Knee Osteoarthritis (Knee OA) | Phase 2 / Phase 3 | Not yet recruiting | Universitas Sriwijaya | 50 | 2026-08-30 | 2026-05-12 |
| Efficacy of Platelet-Rich Plasma Added to Hyaluronic Acid in Knee Osteoarthritis Hyaluronic Acid (HA) and Platelet rich plasma (PRP), Hyaluronic Acid (HA) - Knee Osteoarthritis, Knee Osteoarthritis (Knee OA) | Not applicable | Recruiting | Implai Sp z o.o | 50 | 2026-07-20 | 2026-08-25 |
| Efficacy of Platelet-Rich Plasma Combined With Hyaluronic Acid in Knee Osteoarthritis Hyaluronic Acid (HA) and Platelet rich plasma (PRP), Hyaluronic Acid (HA) - Knee Osteoarthritis, Knee Osteoarthritis (Knee OA) | Not applicable | Recruiting | Implai Sp z o.o | 100 | 2026-07-20 | 2026-08-25 |
| High-Intensity Laser Therapy (HILT) in Patients With Knee Osteoarthritis Conventional Physiotherapy, High-Intensity Laser Therapy (HILT), Sham High-Intensity Laser Therapy - Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | University of Rzeszow | 72 | 2026-07-03 | 2026-06-29 |
| Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis Genicular Artery Embolization, Lipiodol, Simple angiogram - Knee Osteoarthritis, Knee Osteoarthritis (Knee OA) | Phase 2 | Recruiting | University of Utah | 40 | 2026-07-01 | 2026-10-30 |
| Effects of Pressure Biofeedback Training Versus Bolster Foam Roll Training for Pain, Muscles Activation, and Quality of Life Among Knee Osteoarthritis Patients pressure Biofeedback Training, Bolster Foam Roll Training - Knee Osteoarthritis (Knee OA), Knee Arthritis, Osteoarthritis | Not applicable | Recruiting | Lahore University of Biological and Applied Sciences | 48 | 2026-05-01 | 2026-07-28 |
| Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis the strengthening program - Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | Kaohsiung Veterans General Hospital. | 120 | 2026-04-20 | 2026-04-22 |
| Advanced Brain Imaging-TKA (fMRI-TKA) fMRI Brain Scan - Knee Osteoarthritis (Knee OA), Knee Pain Chronic | Not applicable | Recruiting | Ottawa Hospital Research Institute | 50 | 2026-04-01 | 2026-03-11 |
| Effects of Core Stabilization Exercises in Female Patients With Gonarthrosis 10 days of conventional physiotherapy (Hot Pack, TENS, Ultrasound) and 6 weeks of routine knee exercises, Six weeks of core stabilization exercises. - Knee Osteoarthritis (Knee OA) | Not applicable | Recruiting | Cumhuriyet University | 40 | 2026-01-05 | 2026-03-19 |
| Intelligent Precision Knee Preservation System for Knee Osteoarthritis HTO procedure - Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 150 | 2026-01-01 | 2025-12-16 |
| An Implementation Science Approach to Evaluating Self-Administered Acupressure for Knee Osteoarthritis in Older-Aged Adults in the Community Experimental Group: Self-Administered Acupressure (SAA), Control Group: General Health Education - Knee Osteoarthritis (Knee OA) | Not applicable | Recruiting | The Hong Kong Polytechnic University | 368 | 2025-12-20 | 2026-09-21 |
| Efficacy of IPACK Block Combined With Intra-articular Steroid Injection in Advanced Knee Osteoarthritis: A Retrospective Cohort Study Knee Osteoarthritis (Knee OA), IPACK Block Multimodal Analgesia | Completed | Kanuni Sultan Suleyman Training and Research Hospital | 98 | 2025-12-05 | 2026-03-11 | |
| Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR) Somatropin (recombinant human growth hormone), bacteriostatic saline placebo - Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA) | Phase 1 / Phase 2 | Active not recruiting | Dr. David Wasserstein | 34 | 2025-10-31 | 2026-07-31 |
| Home-Based Strategies for Knee Osteoarthritis Home Exercise Group, Topical Therapy Group - Knee Osteoarthritis, Knee Osteoarthritis (Knee OA) | Not applicable | Completed | Istanbul University - Cerrahpasa | 83 | 2025-10-09 | 2026-02-27 |
| EFFECT OF INTRAARTICULAR TRIAMCINOLONE HEXACETONIDE AND BETAMETHASONE ON INTRAOCULAR PRESSURE Diprospan, artropan - Knee Osteoarthritis (Knee OA), Intraocular Pressure | Phase 4 | Completed | Nigde Omer Halisdemir University | 80 | 2025-10-02 | 2025-11-21 |
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Osteoarthritis, Knee (45) · Osteoarthritis (7) · Pain (5) · Chronic Pain (2) · Depression (1) · Fatigue (1) · Fractures, Stress (1) · Inflammation (1) · Kinesiophobia (1) · Knee Injuries (1) · Musculoskeletal Pain (1) · Obesity (1) · Patient Satisfaction (1) · Sleep Initiation and Maintenance Disorders (1)
Arthritis (45) · Joint Diseases (45) · Musculoskeletal Diseases (45) · Rheumatic Diseases (45) · Osteoarthritis (38) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Neurologic Manifestations (8) · Pain (3) · Behavior (2) · Mental Disorders (2) · Wounds and Injuries (2) · Anxiety Disorders (1) · Behavioral Symptoms (1) · Body Weight (1)
Acetaminophen (1) · Adrenal Cortex Hormones (1) · Andrographis paniculata extract (1) · Aquatic Therapy (1) · Breathing Exercises (1) · Caloric Restriction (1) · Congresses as Topic (1) · Cryotherapy (1) · Duloxetine Hydrochloride (1) · Embolization, Therapeutic (1) · Growth Hormone (1) · High-Energy Shock Waves (1) · Human Growth Hormone (1) · Hyaluronic Acid (1) · Isometric Contraction (1)
The Hong Kong Polytechnic University (3) · Implai Sp z o.o (2) · Riphah International University (2) · Ain Shams University (1) · All India Institute of Medical Sciences, Jodhpur (1) · Allegro NV/SA (1) · Ankara Etlik City Hospital (1) · Ankara Training and Research Hospital (1) · Benedict Alter (1) · Cairo University (1) · Chengdu Sport University (1) · Cumhuriyet University (1) · Dr. David Wasserstein (1) · Escola Superior de Tecnologia da Saúde do Porto (1) · Federal State Budgetary Scientific Institution (1)
Turkey (Türkiye) (9) · United States (5) · Pakistan (4) · Egypt (3) · Belgium (2) · Canada (2) · India (2) · Poland (2) · China (1) · France (1) · Hong Kong (1) · Indonesia (1) · Italy (1) · Netherlands (1) · Portugal (1)
Benedict Alter, MD, PhD (1) · Dr. David Wasserstein (1) · Ghulam Fatima, PhD* (1) · Inmaculada Neira, M.D. (1) · Jaromir Jarecki, DSc (1) · Joshua F. Baker, MD MSCE (1) · Lei Zhang, M.D., Ph.D. (1) · Liang Cheng (1) · Lisa Berti, Professor (1) · Mariam O Grase, lecturer physical therapy (1) · Nitesh M Gonnade, MBBS, MD(PMR) (1) · Noran A Elbehary, Professor of physical Therapy (1) · Osman Ahmed, MD (1)
PMID 28170179, PMID 28678854, PMID 31297576, PMID 41638751, PMID 42098611, PMID 42583198
K23NS123429 (1), R21AR082123 (1)