54 completed, 32 unknown, 10 recruiting, 8 terminated. 114 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 114 | Completed 54, Unknown 32, Recruiting 10, Terminated 8, Not yet recruiting 5, Active not recruiting 3, Enrolling by invitation 1, Withdrawn 1 |
Follow Keratoconus: new trials by email Literature Review of Keratoconus trials Research Report on Keratoconus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Performance Evaluation of the OCUTOP Hand-held Corneal Topographer OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment) - Corneal Topography, Dry Eye Syndromes | Not applicable | Not yet recruiting | University of Plymouth | 150 | 2027-01-01 | 2026-10-26 |
| A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light, Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light - Keratoconus | Not applicable | Not yet recruiting | Joseph B. Ciolino, MD | 216 | 2027-01-01 | 2026-04-08 |
| Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and Keratoconus NOA lens type 1, NOA lens type 2 - Keratoconus, Presbyopia | Not applicable | Recruiting | Azalea Vision | 16 | 2026-09-28 | 2026-10-13 |
| Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT Corvis Machine - Keratoconus, Intraocular Pressure | Not applicable | Not yet recruiting | Tanta University | 1 | 2026-07-10 | 2026-05-20 |
| INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia INTACS - Keratoconus | Not applicable | Not yet recruiting | University of California, San Diego | 1000 | 2025-12-01 | 2024-05-07 |
| PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated - Keratoconus | Not applicable | Recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 50 | 2025-09-01 | 2026-01-28 |
| Keraring Implantation Based on Alfonso Nomogram Intrastromal corneal ring segment implantation (ICRS) - Keratoconic Subjects | Not applicable | Completed | Assiut University | 25 | 2025-09-01 | 2026-10-02 |
| Effect of Corneal and Scleral RGP Lenses on Ocular Health and Visual Quality in Keratoconus Rose K2, Onefit MED - Keratoconus, Irregular Astigmatism | Not applicable | Recruiting | University of Aarhus | 50 | 2025-08-15 | 2025-08-24 |
| KeratoConus Data Acquisition With Topography and Aberrometry Ocular Topography and Wavefront Aberrometry - Corneal Ectasia, Keratoconus | Not applicable | Completed | Azalea Vision | 52 | 2025-06-16 | 2026-01-09 |
| First in Human Study to Assess Safety and Efficacy of an Implantable Nitinol Device in the Treatment of Keratoconus Nitinol net for intracorneal implant for keratoconus treatment - Keratoconus | Not applicable | Recruiting | Recornea Srl | 12 | 2024-09-03 | 2026-01-20 |
| Clinical Investigation for a Multifunction Ophthalmic Measurement Device Measurements of physiological parameters of the anterior chamber, Measurements of the Axial biometry - Accommodation Disorder, Keratoconus | Not applicable | Unknown | Essilor International | 378 | 2024-06-10 | 2024-08-21 |
| Investigator Initiated, Prospective Study of Xenia Corneal Lenticule Gebauer Lenticule - Keratoconus, Post-Laser Retinal Condition | Not applicable | Recruiting | The Royal Wolverhampton Hospitals NHS Trust | 15 | 2024-05-15 | 2026-01-15 |
| Efficacy of Corneal Cross-Linking (CXL) in the Treatment of Pediatric Keratoconus Crosslinking - Keratoconus | Not applicable | Completed | Al-Azhar University | 20 | 2024-04-02 | 2025-07-23 |
| Simultaneous pHototherapeutic Keratectomy and corneAl Collagen cRosslinking in Eyes With Keratoconus: a Randomized Trial (SHARK) Corneal collagen cross linking (CXL), Transepithelial phototherapeutic keratectomy (t-PTK) - Keratoconus | Not applicable | Recruiting | Oslo University Hospital | 81 | 2024-02-12 | 2024-02-16 |
| Risk Factors and Progression of Keratoconus cross-linking surgery or intra corneal ring, abstention - Keratoconus | Not applicable | Recruiting | University Hospital, Montpellier | 200 | 2023-06-05 | 2025-09-05 |
| Donors Predisposed by Corneal Collagen Cross-linking in Deep Lamellar Keratoplasty for the Patients With Keratoconus Corneal donors predisposed by CXL, Corneal donors stored in corneal storage media - Keratoconus | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 70 | 2023-06-01 | 2023-06-15 |
| Customized Crosslinking: Safety and Efficacy in an Epithelium-off Accelerated-pulsated Protocol for Thin Keratoconus Corneal Cross Linking - Keratoconus | Not applicable | Unknown | Instituto de Oftalmología Fundación Conde de Valenciana | 20 | 2023-03-01 | 2023-12-07 |
| Effectiveness and Safety of Corneal Collagen Cross Linking After Induction of Stromal Emphysema in Keratoconus Corneal collagen cross-linking with induction of corneal stromal emphysema - Keratoconus | Not applicable | Completed | Cairo University | 39 | 2022-10-01 | 2026-02-23 |
| Accelerated Corneal Collagen Crosslinking Protocols Accelerated crosslinking (ACXL) - Keratoconus | Not applicable | Completed | Assiut University | 45 | 2022-08-01 | 2025-01-29 |
| Theranostic Guided Riboflavin/UV-A Corneal Cross-linking Riboflavin/UV-A corneal cross-linking - Keratoconus | Not applicable | Completed | Regensight | 50 | 2022-04-27 | 2025-02-11 |
Showing 20 of 114. Sign in to see all of them.
Corneal Diseases (8) · Dry Eye Syndromes (6) · Corneal Dystrophies, Hereditary (4) · Corneal Opacity (4) · Dilatation, Pathologic (3) · Eye Diseases (3) · Corneal Injuries (2) · Corneal Wavefront Aberration (2) · Glaucoma (2) · Cataract (1) · Cicatrix (1) · Common Cold (1) · Diabetes Mellitus (1) · Disease Progression (1)
Eye Diseases (111) · Corneal Diseases (106) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Lacrimal Apparatus Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Eye Diseases, Hereditary (5) · Genetic Diseases, Inborn (5) · Nervous System Diseases (3) · Pathological Conditions, Anatomical (3) · Craniocerebral Trauma (2) · Eye Injuries (2) · Facial Injuries (2) · Ocular Hypertension (2) · Pathologic Processes (2) · Refractive Errors (2)
Corneal Cross-Linking (14) · Riboflavin (3) · Tomography, Optical Coherence (3) · Photorefractive Keratectomy (2) · Anesthesia (1) · Anesthesia, General (1) · Botulinum Toxins, Type A (1) · Corneal Topography (1) · Dextrans (1) · Eyeglasses (1) · Flavin Mononucleotide (1) · Keratoplasty, Penetrating (1) · Lasers, Semiconductor (1) · Ophthalmic Solutions (1) · Ultraviolet Rays (1)
Assiut University (4) · Cornea and Laser Eye Institute (3) · Democritus University of Thrace (3) · Federal University of São Paulo (3) · Instituto de Oftalmología Fundación Conde de Valenciana (3) · Moorfields Eye Hospital NHS Foundation Trust (3) · Shahid Beheshti University (3) · Umeå University (3) · University Hospital, Toulouse (3) · University of Waterloo (3) · Azalea Vision (2) · Cairo University (2) · Oregon Health and Science University (2) · Shahid Beheshti University of Medical Sciences (2) · Singapore National Eye Centre (2)
United States (17) · France (10) · Egypt (8) · United Kingdom (8) · Iran (6) · Netherlands (6) · Brazil (5) · China (5) · Italy (5) · Kosovo (3) · Mexico (3) · Spain (3) · Switzerland (3) · Belgium (2) · Canada (2)
Adimara C Renesto, MD (2) · Mahmoud Abdel-Radi, MD (2) · Mukharram Bikbov, Professor (2) · Alexander Levit, FCOptom (1) · Allegonda Van der Lelij, MD PhD (1) · Anders Behndig (1) · Anders Behndig, MD, PhD (1) · Anders Behndig, Professor (1) · Anita Syla Lokaj (1) · Ashraf M Bakhsh, MD (1) · B Ilango (1) · Boris Malyugin, MD,PhD,prof. (1) · Brian J McNeel, OD (1) · Bruce D Allan, MD FRCOphth (1)
PMID 12719068, PMID 10511934, PMID 10548467, PMID 10656302, PMID 10673340, PMID 10951465, PMID 10976937, PMID 11006081, PMID 11527942, PMID 11778801, PMID 11778802, PMID 11978762, PMID 12126755, PMID 14638698, PMID 14741001, PMID 14745032, PMID 15043821, PMID 15050269, PMID 15068441, PMID 15728537, PMID 16368147, PMID 16805116, PMID 16814056, PMID 16877401, PMID 16936089, PMID 17013692, PMID 17081868, PMID 17224118, PMID 17321396, PMID 17413959, PMID 17449031, PMID 17481941, PMID 17531694, PMID 17568210, PMID 17681291, PMID 18216574, PMID 18226798, PMID 18361985, PMID 18626569, PMID 18724146, PMID 18811121, PMID 18977536, PMID 19338611, PMID 19426404, PMID 19553507, PMID 19956410, PMID 20023586, PMID 20373876, PMID 20537579, PMID 20837804
2015 (1), R01EY013178 (1), R01EY018184 (1), R01EY028755 (1)