6 not yet recruiting, 6 recruiting, 1 completed, 1 enrolling by invitation. 6 Not applicable, 2 Phase 4, 1 Early Phase 1, 1 Phase 1, 1 Phase 3.
Follow Indocyanine Green (ICG): new trials by email Literature Review of Indocyanine Green (ICG) trials Research Report on Indocyanine Green (ICG)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Non-inferiority Study of Indocyanine Green-guided Sentinel Lymph Node Mapping Versus Conventional Lymph Node Dissection in Esophageal Cancer ICG-guided sentinel lymph node dissection, ICG-guided systematic lymph node dissection - Esophageal Cancer, Sentinel Lymph Node | Phase 3 | Not yet recruiting | Fujian Medical University Union Hospital | 200 | 2026-10-01 | 2026-08-26 |
| Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction (VISION Trial) Indocyanine Green, Standard clinical perfusion assessment - Head and Neck Cancer (H&N), Free Tissue Flaps | Phase 4 | Recruiting | Region Skane | 244 | 2026-09-28 | 2026-09-29 |
| Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging Laser speckle contrast imaging - Rectal Cancer, Total Mesorectal Excision | Not applicable | Not yet recruiting | University of Aarhus | 100 | 2026-09-01 | 2026-09-11 |
| COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green Laser Speckle Contrast Imaging - Leakage, Anastomotic, Colon Cancer | Not yet recruiting | Leiden University Medical Center | 30 | 2026-08-01 | 2026-07-22 | |
| Application of Indocyanine Green Tracer in D2 Lymphadenectomy of Locally Advanced Gastric Cancer ICG administration - GASTRIC CANCER, Indocyanine Green (ICG) | Not applicable | Not yet recruiting | Hospital of Navarra | 102 | 2026-03-01 | 2025-03-24 |
| Confirming the Accuracy of Endoscopic Marking Using a New Marker, a Novel Luminomarker, in Lesion Marking Before Colorectal Cancer Surgery. LuminoMark inj. 0.2mL - Colorectal Cancer, Endoscopic Tattoo of Suspected Colon Cancer | Not applicable | Enrolling by invitation | Seoul St. Mary's Hospital | 30 | 2025-12-22 | 2026-02-02 |
| A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS cCeLL In vivo, Indocyanine Green - Frozen Sections, Indocyanine Green (ICG) | Phase 1 | Not yet recruiting | VPIX Medical | 30 | 2025-12-01 | 2025-11-28 |
| The Effect of Dose and Storage Conditions of Indocyanine Green on Efficacy and Cost in Sentinel Lymph Node Mapping in Gynecological Cancer Endometrial Cancer, Vulvar Cancers | Recruiting | Cukurova University | 30 | 2025-10-03 | 2026-02-02 | |
| Assessing the Efficacy of Indocyanine Green for Ureter Identification During Robot-Assisted Surgery in Advanced-Stage Endometriosis Indocyanine Green (ICG)-Assisted Ureteral Identification, Standard Ureteral Identification without ICG - Indocyanine Green (ICG), Robotic Surgical Procedure | Phase 4 | Not yet recruiting | Baylor College of Medicine | 40 | 2025-10-01 | 2025-08-28 |
| Implementation of Indocyanine Green to Identify Sentinel Lymph Nodes During Surgery for Breast Cancer Technetium (99mTc), Indocyanine Green, Sentinel lymph node biopsy - Breast Cancer, Sentinel Lymph Node Biopsy (SLNB) | Not applicable | Recruiting | Isabelle Henskens | 1760 | 2025-04-18 | 2026-06-25 |
| Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma Organ-sparing surgery, Standard of care segmental resection - Colon Cancer, Colon Adenocarcinoma | Not applicable | Recruiting | Meander Medical Center | 341 | 2024-12-12 | 2025-11-20 |
| The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor Achalasia, Esophageal, Achalasia | Recruiting | Federico II University | 70 | 2022-11-01 | 2025-09-23 | |
| Finding Sentinel Lymph Nodes During Mastectomy Using Indocyanine Green (INIGMA Study) Indocyanine green (ICG)-fluorescence guided sentinel lymph node biopsy - Breast Cancer, Sentinel Lymph Node Biopsy (SLNB) | Not applicable | Recruiting | Isabelle Henskens | 90 | 2022-08-22 | 2026-01-23 |
| Diagnostic Value of ICG in Endometriosis Indocyanine Green - Endometriosis, Laparoscopy | Early Phase 1 | Completed | Insel Gruppe AG, University Hospital Bern | 63 | 2017-01-01 | 2020-01-18 |
Breast Neoplasms (2) · Colonic Neoplasms (2) · Endometriosis (2) · Lymphatic Metastasis (2) · Rectal Neoplasms (2) · Anastomotic Leak (1) · Brain Neoplasms (1) · Colorectal Neoplasms (1) · Disease (1) · Endometrial Neoplasms (1) · Esophageal Achalasia (1) · Esophageal Neoplasms (1) · Head and Neck Neoplasms (1) · Rectal Diseases (1) · Stomach Neoplasms (1)
Neoplasms (11) · Neoplasms by Site (11) · Digestive System Diseases (7) · Gastrointestinal Diseases (7) · Digestive System Neoplasms (6) · Gastrointestinal Neoplasms (6) · Intestinal Diseases (4) · Intestinal Neoplasms (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Colonic Diseases (3) · Colorectal Neoplasms (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Genital Diseases (3)
Indocyanine Green (6) · Laser Speckle Contrast Imaging (2) · Optical Imaging (1) · Sentinel Lymph Node Biopsy (1) · Technetium (1) · Technetium-99 (1)
Isabelle Henskens (2) · Baylor College of Medicine (1) · Cukurova University (1) · Federico II University (1) · Fujian Medical University Union Hospital (1) · Hospital of Navarra (1) · Insel Gruppe AG, University Hospital Bern (1) · Leiden University Medical Center (1) · Meander Medical Center (1) · Region Skane (1) · Seoul St. Mary's Hospital (1) · University of Aarhus (1) · VPIX Medical (1)
Netherlands (3) · China (1) · Denmark (1) · Italy (1) · South Korea (1) · Spain (1) · Sweden (1) · Switzerland (1) · Turkey (Türkiye) (1) · United States (1)
Annemiek Doeksen, MD, PhD (1) · Bin Zheng (1) · Frank J Voskens (1) · Giovanni Aprea, Prof. (1) · Maria Concepcion Yarnoz, MD, PhD (1) · Pooya Rajabaleyan, MD, PhD (1) · Sara Imboden, MD (1) · Xiaoming Guan, PhD, MD (1)
PMID 18069128, PMID 19362699, PMID 27743072, PMID 28070242, PMID 29697448, PMID 31385481, PMID 31943126, PMID 33394777, PMID 34853560, PMID 35606545, PMID 37814165, PMID 39151436, PMID 39440840, PMID 39900861, PMID 40596151, PMID 40671310, PMID 40933467, PMID 42342397, PMID 42663942
2025 (1)