22 completed, 6 unknown, 5 terminated, 4 recruiting. 10 Phase 2, 9 Phase 1, 6 Not applicable, 5 Phase 4, 3 Phase 3.
Follow Hypogonadotropic Hypogonadism: new trials by email Literature Review of Hypogonadotropic Hypogonadism trials Research Report on Hypogonadotropic Hypogonadism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 20 | 2025-12-09 | 2026-07-13 |
| Opioid Antagonism in Hypogonadotropic Hypogonadism Naloxone - Hypogonadotropic Hypogonadism, Low Testosterone | Phase 1 | Completed | Stephanie B. Seminara, MD | 23 | 2025-06-18 | 2026-06-03 |
| Growing up With the Young Endocrine Support System (YESS!) YESS! game, Snake '97, Transition-toolkit - Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism | Not applicable | Not yet recruiting | dr. Laura C. G. de Graaff-Herder | 160 | 2024-12-01 | 2023-09-07 |
| Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant. Primary Ovarian Insufficiency, Hypogonadotropic Hypogonadism | Recruiting | University of Colorado, Denver | 34 | 2024-07-01 | 2024-12-06 | |
| Low Energy Availability and Pituitary Function (LEAP Study) 5-day controlled metabolic dietary intake - Hypogonadotropic Hypogonadism | Not applicable | Unknown | University of Colorado, Denver | 25 | 2023-04-01 | 2023-04-11 |
| Kisspeptin Administration Subcutaneously to Patients With IHH kisspeptin 112-121, leuprolide acetate - Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 36 | 2023-02-03 | 2026-07-13 |
| Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders Kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 1 | Completed | Stephanie B. Seminara, MD | 13 | 2022-12-16 | 2025-10-03 |
| Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HH Gonadorelin - Hypogonadotropic Hypogonadism | Not applicable | Unknown | Huashan Hospital | 20 | 2022-01-01 | 2022-01-11 |
| A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial Letrozole 2.5mg, hCG, Placebo - Hypogonadism, Hypogonadism, Male | Phase 4 | Terminated | Copenhagen University Hospital, Rigshospitalet | 8 | 2021-11-24 | 2024-02-15 |
| The Molecular Basis of Inherited Reproductive Disorders Hypogonadotropic Hypogonadism, Reproductive Disorder | Completed | Stephanie B. Seminara, MD | 854 | 2021-01-21 | 2026-07-13 | |
| A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism Aveed Injectable Product, Fortesta, Testim - Hypogonadism, Hypogonadism, Male | Phase 4 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 673 | 2020-06-30 | 2025-03-14 |
| Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism | Phase 2 | Completed | Stephanie B. Seminara, MD | 18 | 2019-05-03 | 2026-08-26 |
| Hypothalamic-pituitary Dysfunction in Diabetes Diagnostic testing - Diabete Mellitus, Hypogonadism | Completed | Istituto Auxologico Italiano | 200 | 2018-05-25 | 2024-03-15 | |
| Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043) Corifollitropin alfa, hCG - Hypogonadotropic Hypogonadism | Phase 3 | Completed | Organon and Co | 17 | 2017-02-02 | 2024-05-23 |
| A 6 Month Safety Extension Study of MBGS205 BGS649 - Hypogonadotropic Hypogonadism | Phase 2 | Completed | Mereo BioPharma | 143 | 2016-11-15 | 2023-05-18 |
| Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism Human Menopausal Gonadotropin, Human Chorionic Gonadotropin - Kallmann Syndrome, Hypogonadotropic Hypogonadism | Phase 4 | Unknown | Beijing Children's Hospital | 40 | 2016-08-01 | 2016-08-26 |
| Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism BGS649, Placebo - Hypogonadotropic Hypogonadism | Phase 2 | Completed | Mereo BioPharma | 271 | 2016-05-12 | 2022-09-14 |
| Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome Gonadotropin-releasing Hormone - Hypogonadotropic Hypogonadism | Not applicable | Unknown | Peking Union Medical College Hospital | 20 | 2016-01-01 | 2016-03-10 |
| A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism TAK-448 - Hypogonadotropic Hypogonadism | Phase 2 | Terminated | Takeda | 15 | 2015-02-01 | 2017-03-31 |
| Effect of Intranasal Insulin on LH Concentrations in Man intranasal insulin, placebo (intranasal saline) - Hypogonadotropic Hypogonadism | Phase 1 / Phase 2 | Completed | Texas Tech University Health Sciences Center | 14 | 2014-12-01 | 2019-08-13 |
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Hypogonadism (38) · Kallmann Syndrome (11) · Idiopathic Hypogonadotropic Hypogonadism (4) · Puberty, Delayed (3) · Amenorrhea (2) · Diabetes Mellitus (2) · Eunuchism (2) · Infertility (2) · Insulin Resistance (2) · Polycystic Ovary Syndrome (2) · Puberty, Precocious (2) · Addison Disease (1) · Adrenal Hyperplasia, Congenital (1) · Androgen-Insensitivity Syndrome (1) · Anosmia (1)
Endocrine System Diseases (38) · Gonadal Disorders (38) · Female Urogenital Diseases (14) · Female Urogenital Diseases and Pregnancy Complications (14) · Urogenital Diseases (14) · Congenital Abnormalities (13) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (13) · Disorders of Sex Development (13) · Male Urogenital Diseases (13) · Urogenital Abnormalities (13) · Disorder of Sex Development, 46,XY (12) · Genetic Diseases, Inborn (12) · Nervous System Diseases (5) · Brain Diseases (4) · Central Nervous System Diseases (4)
Gonadotropin-Releasing Hormone (9) · Testosterone (4) · Chorionic Gonadotropin (2) · Clomiphene (2) · Menotropins (2) · Naloxone (2) · follicle stimulating hormone, human, with HCG C-terminal peptide (2) · Anastrozole (1) · Diagnostic Techniques and Procedures (1) · Glycoprotein Hormones, alpha Subunit (1) · Letrozole (1) · Leuprolide (1) · Luteinizing Hormone, beta Subunit (1) · Testosterone Propionate (1) · Zinc (1)
Massachusetts General Hospital (9) · Stephanie B. Seminara, MD (6) · Mereo BioPharma (2) · Organon and Co (2) · University of Colorado, Denver (2) · Amneal Pharmaceuticals, LLC (1) · Beijing Children's Hospital (1) · Centre Hospitalier Universitaire Vaudois (1) · Centro Riproduzione e Andrologia (1) · Copenhagen University Hospital, Rigshospitalet (1) · EMD Serono (1) · Endo USA Inc., a Keenova Therapeutics Company (1) · Federal University of São Paulo (1) · Gulhane School of Medicine (1) · Huashan Hospital (1)
United States (24) · China (4) · Italy (4) · United Kingdom (3) · Brazil (2) · Denmark (2) · Spain (2) · Belgium (1) · Mexico (1) · Netherlands (1) · Russia (1) · South Africa (1) · Switzerland (1) · Turkey (Türkiye) (1)
Stephanie B Seminara, MD (6) · Stephanie Seminara, MD (4) · Hugh Jones (2) · Janet E Hall, M.D. (2) · Ann E Caldwell, PhD (1) · Caroline Michaela Kistorp, professor, MD (1) · Chunxiu Gong, doctor (1) · Coskun Meric (1) · David Hernandez (1) · Julio Abucham, MD, PhD (1) · Laura CG de Graaff, MD PhD (1) · Lawrence Galitz, MD (1)
PMID 31132118, PMID 21209029, PMID 23643382, PMID 29669934, PMID 32034419, PMID 11788640, PMID 12213860, PMID 12788881, PMID 14573733, PMID 15613419, PMID 16606836, PMID 16757106, PMID 16764984, PMID 17074994, PMID 17334928, PMID 17761590, PMID 17959774, PMID 18272894, PMID 19021638, PMID 19567835, PMID 20332248, PMID 20484732, PMID 20696889, PMID 21037178, PMID 2122732, PMID 21247312, PMID 21700882, PMID 22072740, PMID 22319038, PMID 22745237, PMID 22773735, PMID 23095369, PMID 23341491, PMID 23378218, PMID 23533228, PMID 24476074, PMID 2502554, PMID 25131486, PMID 25226293, PMID 25394172, PMID 25825944, PMID 28270212, PMID 28368443, PMID 28368486, PMID 30515210, PMID 3096182, PMID 3098771, PMID 32232399, PMID 32870266, PMID 33813517
U54HD028138 (2), 2014 (1), 2015 (1), R37HD043341 (1)